AI language models in human reproduction research: exploring ChatGPT’s potential to assist academic writing

Human Reproduction, Journal Year: 2023, Volume and Issue: 38(12), P. 2281 - 2288

Published: Oct. 13, 2023

Abstract Artificial intelligence (AI)-driven language models have the potential to serve as an educational tool, facilitate clinical decision-making, and support research academic writing. The benefits of their use are yet be evaluated concerns been raised regarding accuracy, transparency, ethical implications using this AI technology in publishing. At moment, Chat Generative Pre-trained Transformer (ChatGPT) is one most powerful widely debated models. Here, we discuss its feasibility answer scientific questions, identify relevant literature, assist writing field human reproduction. With consideration scarcity data on topic, assessed ChatGPT writing, from six meta-analyses published a leading journal text generated by was compared original blinded reviewers. While can produce high-quality summarize information efficiently, current ability interpret questions limited, it cannot relied upon for literature search or accurate source citation due spread incomplete false information. We advocate open discussions within reproductive medicine community explore advantages disadvantages implementing technology. Researchers reviewers should informed about models, encourage authors transparently disclose use.

Language: Английский

---

Effectiveness and safety of COVID-19 vaccines on maternal and perinatal outcomes: a systematic review and meta-analysis

BMJ Global Health, Journal Year: 2024, Volume and Issue: 9(4), P. e014247 - e014247

Published: April 1, 2024

Objective To assess the effects of COVID-19 vaccines in women before or during pregnancy on SARS-CoV-2 infection-related, pregnancy, offspring and reactogenicity outcomes. Design Systematic review meta-analysis. Data sources Major databases between December 2019 January 2023. Study selection Nine pairs reviewers contributed to study selection. We included test-negative designs, comparative cohorts randomised trials infection-related Non-comparative cohort studies reporting outcomes were also included. Quality assessment, data extraction analysis Two independently assessed quality extracted data. undertook random-effects meta-analysis reported findings as HRs, risk ratios (RRs), ORs rates with 95% CIs. Results Sixty-seven (1 813 947 women) Overall, design studies, pregnant fully vaccinated any vaccine had 61% reduced odds infection (OR 0.39, CI 0.21 0.75; 4 23 927 women; I 2 =87.2%) 94% hospital admission 0.06, 0.01 0.71; 868 =92%). In adjusted hypertensive disorders was by 12% (RR 0.88, 0.82 0.92; studies; 115 085 women), while caesarean section 9% 0.91, 0.85 0.98; 6 30 192 women). observed an 8% reduction neonatal intensive care unit 0.92, 0.87 0.97; 54 569 babies born versus not women. general, vaccination associated increased adverse perinatal Pain at injection site most common side effect (77%, 52% 94%; 11 27 195 Conclusion are effective preventing related complications PROSPERO registration number CRD42020178076.

Language: Английский

---

Safety and Effectiveness of COVID-19 Vaccines During Pregnancy: A Living Systematic Review and Meta-analysis

Drug Safety, Journal Year: 2024, Volume and Issue: 47(10), P. 991 - 1010

Published: July 15, 2024

Pregnant persons are susceptible to significant complications following COVID-19, even death. However, worldwide COVID-19 vaccination coverage during pregnancy remains suboptimal.

Language: Английский

---

Courage in Decision Making: A Mixed-Methods Study of COVID-19 Vaccine Uptake in Women of Reproductive Age in the U.K.

Vaccines, Journal Year: 2024, Volume and Issue: 12(4), P. 440 - 440

Published: April 18, 2024

COVID-19 vaccination rates are lower in women of reproductive age (WRA), including pregnant/postpartum women, despite their poorer COVID-19-related outcomes. We evaluated the experiences 3568 U.K. WRA, 1983 (55.6%) experiencing a pandemic pregnancy, recruited through ZOE COVID Symptom Study app. Two staggered online questionnaires (Oct–Dec 2021: 3453 responders; Aug–Sept 2022: 2129 responders) assessed status, vaccination, and attitudes for/against vaccination. Descriptive analyses included type(s), timing relative to age-based eligibility delay (first >28 days from eligibility), rationale, with content analysis free-text comments. Most responders (3392/3453, 98.2%) were vaccinated by Dec 2021, motivated altruism, supportiveness general, low risk, concerns. Few declined (by Sept/2022: 20/2129, 1.0%), citing risks (pregnancy-specific longer-term), pre-existing immunity, personal/philosophical reasons. delayed although (vs. other WRA) received later (median 3 vs. 0 after eligibility, p < 0.0001). Despite high uptake, concerns adverse effects, misinformation (including healthcare providers), ever-changing government advice, complex decision making. In summary, most this large WRA cohort promptly vaccinated, pregnant/post-partum women. Altruism community benefit superseded personal as reasons for Nevertheless, experienced angst vaccine-related discouragement. These findings should inform strategies WRA.

Language: Английский

---

Birth rate decline in the later phase of the COVID-19 pandemic: the role of policy interventions, vaccination programmes and economic uncertainty

Human Reproduction Open, Journal Year: 2024, Volume and Issue: 2024(3)

Published: Jan. 1, 2024

Abstract STUDY QUESTION What are the factors influencing decline in birth rates observed higher-income countries later phase of COVID-19 pandemic? SUMMARY ANSWER Our results suggest that economic uncertainty, non-pharmaceutical policy interventions, and first wave population-wide vaccination campaign were associated with during 2022. WHAT IS KNOWN ALREADY During pandemic, most briefly declined then shortly recovered, showing no common trends afterwards until early 2022, when they unexpectedly dropped. DESIGN, SIZE, DURATION This study uses data on monthly total fertility (TFRs) adjusted for seasonality calendar effects provided Human Fertility Database (HFD). Births taking place between November 2020 October 2022 correspond to conceptions occurring February January i.e. after onset pandemic but prior Russian invasion Ukraine. The cover 26 countries, including 21 Europe, USA, Canada, Israel, Japan, Republic Korea. PARTICIPANTS/MATERIALS, SETTING, METHODS First, we a descriptive analysis changes TFR. Second, employed linear fixed regression models estimate association explanatory seasonally TFRs. considered three broader sets factors: interventions restricting mobility social activities outside home, progression programmes. MAIN RESULTS AND THE ROLE OF CHANCE We found as measured by increased inflation (P &lt; 0.001), whereas unemployment did not show any link births = 0.677). stringency was linked postponement births, only lower institutional trust 0.003). In higher trust, stricter containment measures positively rates, both year 0.019) and, albeit weakly significant, 0.057). Furthermore, negative share population having received dose TFRs completed primary course (usually consisting two doses) recovery 0.001). LARGE SCALE DATA N/A. LIMITATIONS, REASONS FOR CAUTION research is restricted relatively strong support policies government well wide access modern contraception. allow analyses key characteristics, such age, order, status. WIDER IMPLICATIONS FINDINGS multi-country drivers pandemic. past, periods following epidemics health crises typically births. contrast, our gradual phasing out measures, allowing return more normal work life, contributed declining some countries. addition, indicates women avoided pregnancy completion protocol. FUNDING/COMPETING INTEREST(S) use external funding. authors acknowledge funding from their home institution, Vienna Institute Demography Austrian Academy Sciences, Open-Access Fund Sciences. For purpose open access, have applied CC BY public copyright licence Author Accepted Manuscript versions arising this submission. All declare conflicts interest.

Language: Английский

---

Fertility decline in the later phase of the COVID-19 pandemic: The role of policy interventions, vaccination programmes, and economic uncertainty

medRxiv (Cold Spring Harbor Laboratory), Journal Year: 2024, Volume and Issue: unknown

Published: April 28, 2024

Abstract BACKGROUND During the COVID-19 pandemic, birth rates in most higher-income countries first briefly declined and then shortly recovered, showing no common trends afterwards until early 2022, when they unexpectedly dropped. STUDY FOCUS We analyse monthly changes total fertility during with a special focus on countries. consider three broader sets of explanatory factors: economic uncertainty, policy interventions restricting mobility social activities outside home, role vaccination programmes. DESIGN, DATA This study uses population-wide data adjusted for seasonality calendar effects provided Human Fertility Database (HFD, 2023). Births taking place between November 2020 October 2022 correspond to conceptions occurring February January i.e., after onset pandemic but prior Russian invasion Ukraine. The cover 26 countries, including 21 Europe, United States, Canada, Israel, Japan Republic Korea. METHODS First, we provide descriptive analysis rate (TFR). Second, estimate factors observed swings using linear fixed (within) regression models. MAIN RESULTS find that were associated as measured by increased inflation, stringency interventions, progression campaign, whereas unemployment did not show any link pandemic. LIMITATIONS, REASONS FOR CAUTION Our research is restricted relatively strong support policies government well wide access modern contraception. do allow analysing key characteristics, such age, order status. WIDER IMPLICATIONS OF THE FINDINGS multi-country drivers later phase In past, periods following epidemics health crises typically recovery fertility. contrast, our results gradual phasing out containment measures, allowing return more normal work life, contributed declining addition, indicates some women avoided pregnancy initial roll-out.

Language: Английский

---

Maternal Exposures to COVID-19 Vaccine and Adverse Birth Outcomes: National Population Study in Korea

Journal of Korean Medical Science, Journal Year: 2025, Volume and Issue: 40

Published: Jan. 1, 2025

Language: Английский

---

Fertility dynamics through historical pandemics and COVID-19 in Switzerland, 1871–2022

Population Studies, Journal Year: 2025, Volume and Issue: unknown, P. 1 - 16

Published: March 11, 2025

We follow general fertility rates (GFRs) in Switzerland up to 2022, with a focus on their dynamics during and after pandemics. Historical influenza pandemics (1889–90, 1918–20, 1957) have consistently led temporary declines births between six nine months the pandemic peak. High of miscarriage may explain these findings. After 1889–90 1918–20 pandemics, short-term baby booms occurred. For recent Covid-19 pandemic, appear more complex. The GFR had already been declining since 2018, before hit Switzerland. During shortly first two waves 2020, there was an increase conceptions, leading higher 2021: shutdown measures brought planned pregnancies forwards. Subsequently, declined from February 2022; one possible explanation is that were intentionally postponed until vaccination. Following population-level observations, in-depth studies are needed understand better why affected by

Language: Английский

---

COVID-19 vaccination rates among pregnant women in France: A nationwide cohort study

Vaccine, Journal Year: 2025, Volume and Issue: 53, P. 127070 - 127070

Published: April 1, 2025

Pregnant women are at an elevated risk for severe COVID-19, but nationwide rates of vaccination and its timing during pregnancy not well documented in France. To assess COVID-19 among pregnant France, compare them to those the general population, analyse factors associated with status timing. A study using EPI-MERES register, which includes all 1,203,454 who delivered between April 2021 December 2022 Standardization by age social index was used female population. Associations sociodemographic factors, monitoring indicators, pre-existing comorbidities were measured multivariable logistic regression. Overall, 52 % received least one vaccine dose, 62.1 vaccinated before conception 8.2 %, 20.9 8.8 1st, 2nd, 3rd trimester, respectively. Vaccination initially lagged behind population converged June 2022, a six-month lag. Younger more socially deprived less highly vaccinated. Unvaccinated likely be their third (aOR, 1.21 [1.19-1.22]), had fewer ultrasound scans 0.71 [0; 70-0.73]), often took folic acid 0.73 [0.72-0.74]). Women comorbidities, such as obesity, diabetes, hypertension, antidepressant use, or chronic respiratory disease, unvaccinated (aORs ranged from 0.69 0.89). France than crucial pandemic periods eventually reached similar rates. Socioeconomic level prenatal care strongly low uptake. This should focus future interventions policy adjustments across segments this

Language: Английский

---

COVID and Early Pregnancy

Early pregnancy, Journal Year: 2025, Volume and Issue: unknown, P. 255 - 261

Published: April 16, 2025

Language: Английский

---