Frontiers in Endocrinology,
Journal Year:
2025,
Volume and Issue:
15
Published: Jan. 17, 2025
Endometriosis
can
cause
of
infertility,
and
evaluation
methods
for
predicting
clinical
pregnancy
outcomes
are
desired.
Extracellular
vesicles
(EVs)
exist
in
blood
it
contains
small
non-coding
RNAs
(ncRNAs)
that
may
reflect
disease
severity.
In
this
study,
we
investigated
ncRNAs
serum
EVs
to
identify
specific
biomarkers
pregnancy.
Serum
samples
were
collected
from
48
patients
who
underwent
assisted
reproductive
technology
(ART).
successfully
isolated
characterized
using
nanoparticle
tracking
assays,
electron
microscopy,
western
blotting
EV's
markers.
We
performed
RNA
sequencing
analyzed
microRNA
(miRNA)
profiles
the
infertility
with
without
endometriosis
detect
pregnancy-predicting
biomarkers.
Candidate
miRNAs
selected
by
comparing
became
pregnant
(n
=
13)
those
did
not
21).
A
total
241
detected;
however,
no
trends
separated
two
groups.
Next,
divided
into
4)
non-pregnant
10)
cases.
Among
224
candidate
miRNAs,
miRNA
women
receiver-operating
characteristics
(ROC)
curve
analysis
(area
under
[AUC]
>
0.8).
endometriosis,
be
useful
possible
before
treatment.
Finally,
used
tissue
demonstrate
produced
lesions.
Although
predictors
found
could
provide
novel
noninvasive
predict
have
potential
applicability
ART.
Further
studies
required
examine
functional
importance
these
elucidate
pathological
mechanisms
Biomolecules,
Journal Year:
2025,
Volume and Issue:
15(1), P. 69 - 69
Published: Jan. 6, 2025
Endometriosis
is
a
chronic,
estrogen-dependent
disorder
associated
with
the
presence
of
endometrial
cells
mainly
in
pelvic
cavity,
causing
systemic
immune
inflammation,
infertility,
epigenetic
dysregulation
differential
DNA
methylation,
coelomic
metaplasia,
and
pain.
It
affects
approximately
10-12%
women.
Despite
decades
research,
full
pathophysiology,
diagnostic
roadmap,
clinical
management
strategies
for
endometriosis
are
not
yet
fully
elucidated.
Cell-free
(Cf-DNA)
peripheral
blood
diseased
healthy
individuals
was
discovered
1950s.
Quantifying
Cf-DNA
specific
methylation
group
genes
have
been
proposed
as
potential
non-invasive
biomarkers
somatic
constitutional
genetics
various
other
pathological
disorders.
In
this
study,
we
investigated
levels
78
young
women,
38
whom
had
confirmed
via
laparoscopy
40
were
healthy.
We
found
significant
difference
between
two
groups
when
quantified,
3.9
times
more
serum
women
endometriosis.
also
identified
nine
target
potentially
involved
pathogenesis
endometriosis,
different
profile
groups.
Our
data
suggest
that
combination
cell-free
quantification
assessment
signature
can
be
predictive
test
Journal of Ovarian Research,
Journal Year:
2024,
Volume and Issue:
17(1)
Published: Aug. 5, 2024
Extracellular
vesicles
(EVs),
particles
enriched
in
bioactive
molecules
like
proteins,
nucleic
acids,
and
lipids,
are
crucial
mediators
of
intercellular
communication
play
key
roles
various
physiological
pathological
processes.
EVs
have
been
shown
to
be
involved
ovarian
follicular
function
altered
two
prevalent
gynecological
disorders;
polycystic
syndrome
(PCOS)
endometriosis.
Ovarian
follicles
complex
microenvironments
where
folliculogenesis
takes
place
with
well-orchestrated
interactions
between
granulosa
cells,
oocytes,
their
surrounding
stromal
cells.
Recent
research
unveiled
the
presence
EVs,
including
exosomes
microvesicles,
fluid
(FFEVs),
which
constitutes
part
developing
oocyte's
microenvironment.
In
context
PCOS,
a
multifaceted
endocrine,
reproductive,
metabolic
disorder,
studies
explored
dysregulation
these
FFEVs
cargo.
Nine
PCOS
were
included
this
review
miRNAs
commonly
reported
different
studies,
miR-379
miR-200,
both
known
role
female
reproduction.
Studies
also
demonstrated
potential
use
as
diagnostic
tools
treatment
options.
Endometriosis,
another
disorder
characterized
by
ectopic
growth
endometrial-like
tissue,
has
linked
aberrant
EV
signaling.
peritoneal
women
endometriosis
carry
that
modulate
immune
response
promote
establishment
maintenance
lesions.
derived
from
lesions,
serum
obtained
patients
showed
no
biomolecules
eleven
reviewed
studies.
Importantly,
circulating
biomarkers,
reflecting
severity
pathology.
Understanding
interplay
within
human
may
provide
valuable
insights
into
pathophysiology
Targeting
EV-mediated
open
avenues
for
novel
therapeutic
approaches
common
disorders.
More
is
essential
unravel
mechanisms
underlying
involvement
its
endometriosis,
ultimately
leading
more
effective
personalized
interventions.
Human Reproduction Open,
Journal Year:
2024,
Volume and Issue:
2024(3)
Published: Jan. 1, 2024
However,
a
very
comprehensive
understanding
is
needed
to
detect
and
investigate
the
physiological,
cytological
immunological
events,
as
well
biochemical
factors
like
oxidative
stress
inflammation,
encountered
in
pelvic
microenvironment
of
endometriosis
patients.In
this
issue
Human
Reproduction
Open,
Chaggar
et
al
(2024)
report
high
rates
deep
induced
by
hemoperitoneum.In
our
invited
commentary,
we
review
role
blood,
hemoglobin
(Hb)
iron
pathogenesis,
looking
elucidate
possible
link
suggested
article.
Hemoglobin
ironErythrocytes
carried
into
peritoneal
cavity
menstrual
reflux
and/or
bleeding
lesions
are
known
be
inducers
(Van
Langendonckt
2002a,b;Defrère
al,
2006Defrère
,
2008Defrère
2011;;Lousse
2009Lousse
2012)).Indeed,
erythrocytes
likely
release
pro-oxidant
proinflammatory
Hb
its
highly
toxic
by-products
heme
environment
2002a,b)
(Figure
1).Unless
they
properly
chelated,
free
become
key
players
formation
deleterious
ROS
