Health Expectations,
Journal Year:
2024,
Volume and Issue:
27(5)
Published: Oct. 1, 2024
ABSTRACT
Objective
The
aim
of
this
study
is
to
identify
and
explore
the
unmet
needs
adolescents
young
adults
living
with
endometriosis.
Design
An
open‐ended
online
survey
was
conducted,
questions
derived
from
prior
research
looking
at
areas
need
in
healthcare,
career
work,
financial,
information,
psychological,
social
cultural
domains.
Setting
Population
Self‐selecting
18‐25
year
olds
surgically
diagnosed
endometriosis
(self‐reported)
currently
Australia
were
included
as
participants.
Methods
Invitation
participate
an
shared
through
media
Australian
organisations
Royal
Women's
Hospital,
Melbourne.
Surveys
analysed
qualitatively
template
analysis.
Main
Outcome
Measures
Recording
supportive
care
population
carried
out.
Results
One
hundred
thirty‐one
respondents
fit
eligibility
criteria
being
aged
18–25
years
(median
age
23
years).
Most
born
(94%),
university‐educated
(54%)
lived
a
metropolitan
setting
(69%).
There
range
that
presented
across
education,
healthcare
relationships.
Group‐specific
challenges
identified:
doctors
either
over‐
or
underemphasising
future
fertility;
disrupted
sexual
romantic
life
due
painful
sex;
managing
pain
classroom
workplace
where
periods
are
taboo;
gender‐queer
gynaecological
medical
spaces.
Conclusions
increasingly
which
patients
receiving
diagnosis
precipitates
shift
patient
care.
treatment
decisions
made
must
be
reflective
unique
who
carry
burden
disease.
Clinicians
advised
aware
discuss
their
patients.
Patient
Public
Contribution
nine
developed
data
preliminary
series
interviews
tertiary
women's
centre.
In
asking
these
data‐informed
community,
broader
sociocultural
demographics
disease
states
(including
less
symptomatic
endometriosis)
have
provided
understanding
needs.
Journal of Endometriosis and Uterine Disorders,
Journal Year:
2024,
Volume and Issue:
8, P. 100083 - 100083
Published: May 23, 2024
Anogenital
distance
is
a
well-validated
marker
of
prenatal
testosterone,
with
shorter
distances
indicating
lower
levels
during
early
gestation.
A
suite
studies
has
tested
for
links
anogenital
risk
endometriosis,
but
the
findings
are
variable,
leading
to
uncertainty
in
interpretation.
This
study
was
conducted
provide
an
overall
statistical
assessment
whether
altered
women
compared
controls.
systematic
review
and
meta-analysis
were
on
association
endometriosis
distance.
Three
databases
queried
identification
phase,
random-effects
applied
data
that
met
inclusion
criteria.
Meta-analysis
showed
AF,
measured
from
anus
posterior
fourchette,
significantly
associated
higher
meta-analysis.
By
contrast,
AC,
clitoral
surface,
non-significant.
Both
analyses
demonstrated
significant
heterogeneity
across
studies.
Too
few
available
robust
investigation
publication
bias.
The
short
provides
support
hypothesis
represents,
part,
disorder
mediated
by
relatively
low
testosterone
development.
conclusion
implications
understanding
causes
treatment
endometriosis.
Biomedicines,
Journal Year:
2024,
Volume and Issue:
12(11), P. 2521 - 2521
Published: Nov. 4, 2024
Endometriosis
and
inflammatory
bowel
disease
(IBD)
share
some
epidemiological,
clinical
pathogenetic
features.
A
differential
diagnosis
between
pelvic
endometriosis
IBD
may
be
challenging,
even
for
expert
clinicians.
In
the
present
review,
we
aimed
to
summarize
currently
available
data
regarding
relationship
their
possible
association.
Journal of Endometriosis and Uterine Disorders,
Journal Year:
2023,
Volume and Issue:
5, P. 100058 - 100058
Published: Dec. 29, 2023
Endometriosis
is
considered
one
of
the
conditions
that
receives
disproportionately
low
research
funding
relative
to
its
burden.
However,
volume
provided
by
European
Commission
(EC)
for
this
disease
in
last
decades
poorly
known
among
researchers
and
policymakers.
This
study
aimed
estimate
commitment
endometriosis
Union
(EU)
over
years.
Research
projects
dedicated
or
partially
related
were
identified
COmmunity
Development
Information
Service
(CORDIS)
database
inventories
EU
projects.
From
database,
we
extracted
all
items
using
keyword
"endometriosis"
from
inception
2023.
retrieved
classified
three
groups
according
level
specific
field.
Of
145,983
overall
fields
CORDIS,
n
=
27
found
be
endometriosis,
which
10
endometriosis-specific
7
endometriosis.
The
received
funds
about
15
million
euros.
specifically
4
identify
candidate
diagnostic
biomarkers
associated
with
3
had
a
broader
approach
focused
on
both
improvement
therapeutic
measures
disease.
Considering
economic
societal
burden
incurred
investments
has
been
so
far
limited.
funded
mainly
diagnosis
while
few
etiopathogenesis
treatment.
Human Reproduction Open,
Journal Year:
2024,
Volume and Issue:
2024(3)
Published: Jan. 1, 2024
However,
a
very
comprehensive
understanding
is
needed
to
detect
and
investigate
the
physiological,
cytological
immunological
events,
as
well
biochemical
factors
like
oxidative
stress
inflammation,
encountered
in
pelvic
microenvironment
of
endometriosis
patients.In
this
issue
Human
Reproduction
Open,
Chaggar
et
al
(2024)
report
high
rates
deep
induced
by
hemoperitoneum.In
our
invited
commentary,
we
review
role
blood,
hemoglobin
(Hb)
iron
pathogenesis,
looking
elucidate
possible
link
suggested
article.
Hemoglobin
ironErythrocytes
carried
into
peritoneal
cavity
menstrual
reflux
and/or
bleeding
lesions
are
known
be
inducers
(Van
Langendonckt
2002a,b;Defrère
al,
2006Defrère
,
2008Defrère
2011;;Lousse
2009Lousse
2012)).Indeed,
erythrocytes
likely
release
pro-oxidant
proinflammatory
Hb
its
highly
toxic
by-products
heme
environment
2002a,b)
(Figure
1).Unless
they
properly
chelated,
free
become
key
players
formation
deleterious
ROS
medRxiv (Cold Spring Harbor Laboratory),
Journal Year:
2024,
Volume and Issue:
unknown
Published: Jan. 7, 2024
Abstract
Background
Anogenital
distance
is
a
well-validated
marker
of
prenatal
testosterone,
with
shorter
distances
indicating
lower
levels
during
early
gestation.
A
suite
studies
has
linked
anogenital
risk
endometriosis,
but
the
findings
are
variable,
leading
to
uncertainty
in
interpretation.
The
relationship
endometriosis
especially
important
because
testosterone
been
associated
recent
Mendelian
Randomization
studies,
which
implies
causality
association,
direct
implications
for
future
research
and
treatment.
Methods
systematic
review
meta-analysis
was
conducted
on
association
distance.
Three
databases
were
queried
identification
phase,
random-effects
applied
data
that
met
inclusion
criteria.
Results
Shorter
AF,
measured
from
anus
posterior
fourchette,
significantly
higher
meta-analysis.
By
contrast,
there
no
such
AC,
clitoral
surface.
Both
analyses
demonstrated
significant
heterogeneity
across
studies.
Too
few
available
robust
investigation
publication
bias.
Conclusions
short
provides
support
hypothesis
represents,
part,
disorder
mediated
by
relatively
low
development.
This
conclusions
notable
understanding
causes
treatment
endometriosis.
Journal of Endometriosis and Uterine Disorders,
Journal Year:
2024,
Volume and Issue:
6, P. 100063 - 100063
Published: Feb. 20, 2024
Two
recent
genomic
studies
have
demonstrated
that
lower
genetically-predicted
testosterone
is
associated
with
higher
risk
of
endometriosis.
These
results
are
concordant
a
suite
additional
findings,
including:
(1)
links
endometriosis
and
its
correlates
shorter
anogenital
distance
(an
indicator
prenatal
testosterone),
(2)
pain
sensitivity
under
in
humans
animal
models,
(3)
associations
levels
key
endocrine
endometriosis,
including
antimullerian
hormone,
luteinizing
β-endorphin,
(4)
data
from
models
showing
development
distances,
earlier
onset
estrus,
more-regular
ovulatory
cycles.
Taken
together,
this
evidence
supports
'two-hit'
model
whereby
low
differentially
programs
the
hypothalamic-pituitary-ovarian
axis
such
way
as
to
increase
vulnerability,
adult
testosterone,
combined
early
menarche,
high
sensitivity,
other
genetic
environmental
factors,
leads
increased
rates
high-risk
women.
Most
importantly,
these
phenotypic
findings
suggest
represents
disorder
well
estrogen,
indicate
effects
women
urgently
needed.
Biomolecules,
Journal Year:
2024,
Volume and Issue:
14(5), P. 549 - 549
Published: May 3, 2024
Background:
There
has
been
considerable
progress
in
our
understanding
of
endometriosis,
but
its
pathophysiology
remains
uncertain.
Uncovering
the
underlying
mechanism
rare
instances
endometriosis
reported
early
postmenarcheal
years
and
girls
before
menarche
can
have
wide
implications.
Methods:
We
conducted
a
literature
review
all
relevant
articles
on
Medline.
Results:
In
review,
we
explore
pathogenetic
theories
premenarcheal
role
retrograde
menstruation
adult
potential
early-onset
disease,
as
well
factors
that
argue
against
existence
link
between
(EOE)
neonatal
uterine
bleeding
(NUB).
Conclusions:
As
with
women,
pathogenesis
disease
unclear.
A
NUB
EOE
is
plausible,
there
are
challenges
to
collating
supporting
evidence.
The
state
development
leaves
many
unknowns
need
exploration.
These
include
proof
viable
endometrial
cells
or
mesenchymal
stem
NUB,
their
passage
pelvic
cavity,
possible
response
steroids,
whether
they
reside
within
cavity
remain
dormant
till
menarche.
Health Expectations,
Journal Year:
2024,
Volume and Issue:
27(5)
Published: Oct. 1, 2024
ABSTRACT
Objective
The
aim
of
this
study
is
to
identify
and
explore
the
unmet
needs
adolescents
young
adults
living
with
endometriosis.
Design
An
open‐ended
online
survey
was
conducted,
questions
derived
from
prior
research
looking
at
areas
need
in
healthcare,
career
work,
financial,
information,
psychological,
social
cultural
domains.
Setting
Population
Self‐selecting
18‐25
year
olds
surgically
diagnosed
endometriosis
(self‐reported)
currently
Australia
were
included
as
participants.
Methods
Invitation
participate
an
shared
through
media
Australian
organisations
Royal
Women's
Hospital,
Melbourne.
Surveys
analysed
qualitatively
template
analysis.
Main
Outcome
Measures
Recording
supportive
care
population
carried
out.
Results
One
hundred
thirty‐one
respondents
fit
eligibility
criteria
being
aged
18–25
years
(median
age
23
years).
Most
born
(94%),
university‐educated
(54%)
lived
a
metropolitan
setting
(69%).
There
range
that
presented
across
education,
healthcare
relationships.
Group‐specific
challenges
identified:
doctors
either
over‐
or
underemphasising
future
fertility;
disrupted
sexual
romantic
life
due
painful
sex;
managing
pain
classroom
workplace
where
periods
are
taboo;
gender‐queer
gynaecological
medical
spaces.
Conclusions
increasingly
which
patients
receiving
diagnosis
precipitates
shift
patient
care.
treatment
decisions
made
must
be
reflective
unique
who
carry
burden
disease.
Clinicians
advised
aware
discuss
their
patients.
Patient
Public
Contribution
nine
developed
data
preliminary
series
interviews
tertiary
women's
centre.
In
asking
these
data‐informed
community,
broader
sociocultural
demographics
disease
states
(including
less
symptomatic
endometriosis)
have
provided
understanding
needs.
