Causes of embryo implantation failure: A systematic review and metaanalysis of procedures to increase embryo implantation potential

Frontiers in Endocrinology, Journal Year: 2025, Volume and Issue: 15

Published: Feb. 14, 2025

Introduction Infertility is characterized by the failure to conceive after 12 months of unprotected sexual intercourse. In assisted reproduction technologies (ARTs), in-vitro fertilization and embryo transfer (IVF-ET) are pivotal, with quality essential for successful implantation. Objective This systematic review meta-analysis aimed explore prevalence embryonic factors involved in implantation process, concentrating on following research inquiries: 1) rates euploid versus untested transfers; 2) efficiency transferring good embryos different age groups; 3) impact transfers gestational carriers; 4) donated gametes/embryos. The goal identify critical points improve therapies. Methods A comprehensive literature search identified 1474 relevant papers, 11 which met inclusion criteria. information was gathered using a standardized form, risk bias evaluated. subgroups determine conducted synthesize results. Furthermore, data extracted from registries document persistent secondary role extraembryonic determinants Results demonstrated that preimplantation genetic testing aneuploidy (PGT-A) significantly increased odds Age found influence factors, older women experiencing reduced as carriers. However, overall incidence low. highlights need focus PGT-A, diagnostic hysteroscopy, endometrial receptivity improving rates. Conclusion Implantation success ARTs largely depends euploidy. While achieving three greatly increases rates, it challenging women. Extraembryonic although present, have marginal impact. Subsequent studies ought concentrate modulating responses immunologically developing algorithms precision predicting success; well timing occurrence dormant phenomena also warrants further investigation.

Language: Английский

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Recurrent implantation failure: science or fiction?

Human Reproduction, Journal Year: 2025, Volume and Issue: unknown

Published: Jan. 22, 2025

Graphical AbstractThe September 2024 ESHRE Journal Club discussion focused on a study by Gill et al. (2024) the available evidence to define RIF, embryonic factors that can lead implantation failure of euploid blastocyst, (im)possibility endometrium playing role in and implications for patients transferring all blastocysts from stimulation cycle. PGT-A, preimplantation genetic testing aneuploidy; recurrent failure.Open new tabDownload slide

Language: Английский

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Add-On Technologies That Aim to Improve Oocyte Quality and Embryo Implantation Potential

Medicina, Journal Year: 2025, Volume and Issue: 61(3), P. 367 - 367

Published: Feb. 20, 2025

Advancements in assisted reproductive technologies (ARTs) have led to the development of various add-on techniques aimed at improving oocyte quality and enhancing embryo implantation potential. These target critical stages both physiology, including growth maturation, fertilization, chromosomal status, development. Key approaches involve optimization vitro fertilization (IVF) protocols, recruiting capable follicles giving rise dynamic oocytes evolve, culture media supplementation, preimplantation genetic testing (PGT), mitochondrial replacement therapy (MRT), all which are designed enhance competence through its function metabolism. The use PGT has been promising selecting embryos suitable for transfer, thus optimizing success. Emerging technologies, such as platelet-rich plasma treatment (PRP), time-lapse imaging (TLI), hyaluronan-rich (HA) media, claim improve ovarian rejuvenation uterine receptivity, selection, well potential, respectively. Evidence certain remains limited, but ongoing research suggests that treatments may lead increased clinical pregnancies live birth rates, especially poor-prognosis patients. present review describes current state innovations, their mechanisms action, possibilities increase ART success rates.

Language: Английский

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Transcriptomic landscape of cumulus cells from patients <38 years old with a history of poor ovarian response (POR) treated with platelet-rich plasma (PRP)

Aging, Journal Year: 2025, Volume and Issue: unknown

Published: Feb. 18, 2025

Aging | doi:10.18632/aging.206202. Leah M. Roberts, Nola Herlihy, Andres Reig, Shiny Titus, Rolando Garcia-Milian, James Knight, Raziye Melike Yildirim, Cheri K. Margolis, Yigit Cakiroglu, Bulent Tiras, Christine V. Whitehead, Marie D. Werner, Emre Seli

Language: Английский

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Comparative efficacy of intrauterine infusion treatments for recurrent implantation failure: a network meta-analysis of randomized controlled trials

Journal of Assisted Reproduction and Genetics, Journal Year: 2025, Volume and Issue: unknown

Published: March 4, 2025

Language: Английский

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Cumulative live birth rates of 31 478 untested embryos from 11 463 women challenge traditional recurrent implantation failure definitions

Human Reproduction, Journal Year: 2025, Volume and Issue: unknown

Published: March 10, 2025

Abstract STUDY QUESTION Is there evidence of a plateau in the cumulative live birth rate (cLBR) after certain number consecutive transfers untested embryos? SUMMARY ANSWER In our cohort 11 463 women, cLBR continues to increase with each additional transfer an embryo, reaching 68.3% six blastocyst and 78.0% 10 transfers. WHAT IS KNOWN ALREADY While success rates ART are rising, implantation failure remains persistent challenge. The actual frequency recurrent (RIF) whether RIF surpasses inherent potential transferred embryos matter debate. A recent study reported 98% five euploid transfers, suggesting that most failures likely embryonic rather than endometrial. However, it unclear how these findings can be extrapolated patients who did not undergo preimplantation genetic testing for aneuploidy (PGT-A). theoretical models estimate probabilities based on published euploidy by female age, real-world data routine clinical practice remain limited. DESIGN, SIZE, DURATION This non-interventional retrospective included records all completed IVF/ICSI cycles (including thus fresh frozen–thawed one oocyte retrieval cycle) women underwent at Ghent University Hospital between January 2010 December 2022. After excluding treatments involving PGT, donation surrogacy, or mix cleavage stage dataset consisted total 19 378 cycles, resulting 31 478 embryo PARTICIPANTS/MATERIALS, SETTING, METHODS (‘time’) until achieving (‘event’) was analysed using Kaplan–Meier approach inverse probability weighting (IPW). Additionally, logistic regression analysis conducted assess predictive value previously (LBRs) second subsequent adjusting quality embryos, (cleavage versus stage). MAIN RESULTS AND THE ROLE OF CHANCE estimates IPW showed cLBRs increasing from 51.1% (95% CI: 49.2–53.0%) third, up 64.6–72.0%) sixth even as high 69.5–86.5%) tenth transfer, respectively. As maternal age increases, higher numbers blastocysts required achieve same cLBR. Moreover, no category achieves 80% eight blastocysts. Maternal has considerable effect, illustrated fourth 68.9% 65.8–71.8%) &lt;35 years; 57.6% 50.4–64.8%) 35–37 42.9% 37.5–48.4%) 38–40 16.3% 10.7–21.8%) 41–42 13.5% 3.2–23.7%) &gt;42 years, adjusted analysis, odds estimated decrease transferred; however, this effect is statistically significant (OR = 0.91; 95% 0.86–1.07). Female expected, predictor 0.92; 0.91–0.93). being assigned strategy also 1.34; 1.20–1.51), proportion classified excellent good predefined morphological criteria out 1.21; 1.06—1.38). Implantation correlated response stimulation (P 0.016) formation &lt; 0.0001). There difference LBR equal unsuccessful depending many collection took reach LIMITATIONS, REASONS FOR CAUTION results limited observational design, while analyses were confounding factors, residual may persist, particularly given heterogeneity treatments. We exclude factors associated less favourable reproductive outcomes because goal evaluate practice. WIDER IMPLICATIONS FINDINGS Our emphasize successful multiple Factors such quality, ovarian stimulation, influence outcomes. By addressing multifaceted influences, research provides valuable insights hopeful outlook undergoing fertility treatment. FUNDING/COMPETING INTEREST(S) L.D. received grant Agency Innovation through Science (IWT SB-141441). funder have any role design; collection, interpretation data; writing report; nor decision submit paper publication. authors declare absence commercial financial relationships could construed conflict interest. TRIAL REGISTRATION NUMBER N/A.

Language: Английский

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The application value of routine office hysteroscopy prior in patients with one embryo transferred failure and normal transvaginal ultrasound

Journal of Obstetrics and Gynaecology Research, Journal Year: 2025, Volume and Issue: 51(4)

Published: March 27, 2025

Abstract Aim The aim of our study was to investigate whether outpatient hysteroscopy performed in the month before starting an embryo transfer cycle women who had experienced one failed vitro fertilization treatment could improve outcome. Methods This retrospective analysis selected patients were failures after first good‐quality embryos between January 2019 February 2023; did not undergo IVF, and ultrasound observe pathological abnormalities. A total 199 included for analysis, 119 females hysteroscopic group 80 controlled group. Women underwent examination 3–7 days clean menstrual period. Results There no statistically significant difference groups demographic features characteristics. logistic regression showed that performing prior transferred failure normal transvaginal scan findings influencing factor live birth rate. Conclusions Performing diagnostic fertility outcomes. Hence, routine usage should be offered without previously detected pathology uterine cavity.

Language: Английский

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Endometrial immune assessment in patients with a history of previous euploid blastocyst failure

Frontiers in Immunology, Journal Year: 2025, Volume and Issue: 16

Published: April 7, 2025

Influx and establishment of key endometrial immune factors in the mid-luteal phase menstrual cycle is paramount for successful embryo implantation. Endometrial dysregulation associated with repeated implantation failure miscarriage. In vitro fertilisation cycles, approximately 30% embryos diagnosed as chromosomally normal will still fail to produce a viable live birth, yet such endometrium are rarely clinically explored. this retrospective analysis, clinical outcomes were compared between patients undergoing their first euploid transfer conventional substituted (n=612), similar after previous (n=149) study group who received modified preparatory regimen following profiling targeting uterine natural killer cell recruitment, maturity activity well regulatory counterparts (n=37). Significant differences found attempt failures didn't use testing (implantation rate 63% vs 51, P=0.02; pregnancy rates 55% 40%, P=0.002; birth 50% 38%, P=0.02). Patients underwent subsequent personalised plan exhibited trend towards improved than those no 65% 51%; 57% 40%; 54% respectively) although statistical significance was not demonstrated. Clinical comparable 63%; 55%; 50%, respectively). had failed when using lower chances repeating treatment, unless they preparation derived from results profiling. These preliminary findings indicate potential value guiding management based on testing.

Language: Английский

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Microbiome–Maternal Tract Interactions in Women with Recurrent Implantation Failure

Microorganisms, Journal Year: 2025, Volume and Issue: 13(4), P. 844 - 844

Published: April 7, 2025

Microorganisms play an important role in regulating various biological processes our bodies. In women, abnormal changes the reproductive tract microbiome are associated with gynecological diseases and infertility. Recent studies suggest that patients recurrent implantation failure (RIF) have a reduced genus Lactobacillus population, predominant bacterial species vagina uterus protects from pathogenic growth via production of metabolites (e.g., lactic acid, bacteriocin, H2O2). Moreover, higher percentage bacteria genera, including Atopobium, Gardnerella, Prevotella, Pseudomonas, Streptococcus, was found RIF patients. This review aimed to examine RIF, determine factors altering endometrial microbiome, assess impact on embryo RIF. Several can influence microbial balance, extrinsic elements such as semen antibiotics, which lead dysbiosis female affect implantation. Additionally, probiotics Lacticaseibacillus rhamnosus were reported clinical potential Future needed develop targeted probiotic therapies restore balance enhance fertility outcomes. Research should also focus understanding mechanisms by microorganisms generate suppress for Identifying these interactions may contribute innovative microbiome-based interventions health.

Language: Английский

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Resolving recurrent implantation failure

Reproductive BioMedicine Online, Journal Year: 2025, Volume and Issue: 50(4), P. 104827 - 104827

Published: April 1, 2025

Language: Английский

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