Causes of embryo implantation failure: A systematic review and metaanalysis of procedures to increase embryo implantation potential DOI Creative Commons

Francesco Maria Bulletti,

Romualdo Sciorio, Alessandro Conforti

et al.

Frontiers in Endocrinology, Journal Year: 2025, Volume and Issue: 15

Published: Feb. 14, 2025

Introduction Infertility is characterized by the failure to conceive after 12 months of unprotected sexual intercourse. In assisted reproduction technologies (ARTs), in-vitro fertilization and embryo transfer (IVF-ET) are pivotal, with quality essential for successful implantation. Objective This systematic review meta-analysis aimed explore prevalence embryonic factors involved in implantation process, concentrating on following research inquiries: 1) rates euploid versus untested transfers; 2) efficiency transferring good embryos different age groups; 3) impact transfers gestational carriers; 4) donated gametes/embryos. The goal identify critical points improve therapies. Methods A comprehensive literature search identified 1474 relevant papers, 11 which met inclusion criteria. information was gathered using a standardized form, risk bias evaluated. subgroups determine conducted synthesize results. Furthermore, data extracted from registries document persistent secondary role extraembryonic determinants Results demonstrated that preimplantation genetic testing aneuploidy (PGT-A) significantly increased odds Age found influence factors, older women experiencing reduced as carriers. However, overall incidence low. highlights need focus PGT-A, diagnostic hysteroscopy, endometrial receptivity improving rates. Conclusion Implantation success ARTs largely depends euploidy. While achieving three greatly increases rates, it challenging women. Extraembryonic although present, have marginal impact. Subsequent studies ought concentrate modulating responses immunologically developing algorithms precision predicting success; well timing occurrence dormant phenomena also warrants further investigation.

Language: Английский

Causes of embryo implantation failure: A systematic review and metaanalysis of procedures to increase embryo implantation potential DOI Creative Commons

Francesco Maria Bulletti,

Romualdo Sciorio, Alessandro Conforti

et al.

Frontiers in Endocrinology, Journal Year: 2025, Volume and Issue: 15

Published: Feb. 14, 2025

Introduction Infertility is characterized by the failure to conceive after 12 months of unprotected sexual intercourse. In assisted reproduction technologies (ARTs), in-vitro fertilization and embryo transfer (IVF-ET) are pivotal, with quality essential for successful implantation. Objective This systematic review meta-analysis aimed explore prevalence embryonic factors involved in implantation process, concentrating on following research inquiries: 1) rates euploid versus untested transfers; 2) efficiency transferring good embryos different age groups; 3) impact transfers gestational carriers; 4) donated gametes/embryos. The goal identify critical points improve therapies. Methods A comprehensive literature search identified 1474 relevant papers, 11 which met inclusion criteria. information was gathered using a standardized form, risk bias evaluated. subgroups determine conducted synthesize results. Furthermore, data extracted from registries document persistent secondary role extraembryonic determinants Results demonstrated that preimplantation genetic testing aneuploidy (PGT-A) significantly increased odds Age found influence factors, older women experiencing reduced as carriers. However, overall incidence low. highlights need focus PGT-A, diagnostic hysteroscopy, endometrial receptivity improving rates. Conclusion Implantation success ARTs largely depends euploidy. While achieving three greatly increases rates, it challenging women. Extraembryonic although present, have marginal impact. Subsequent studies ought concentrate modulating responses immunologically developing algorithms precision predicting success; well timing occurrence dormant phenomena also warrants further investigation.

Language: Английский

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