Life,
Journal Year:
2024,
Volume and Issue:
14(3), P. 369 - 369
Published: March 11, 2024
Over
the
past
half
a
century
many
countries
have
witnessed
rapid
fall
in
total
fertility
rates,
particularly
world's
most
advanced
economies
including
industrial
powerhouses
of
Eastern
Asia
and
Europe.
Such
nations
now
passed
through
first
second
demographic
transitions
are
currently
exhibiting
rates
well
below
replacement
threshold
2.1,
with
no
sign
recovery.
This
paper
examines
factors
responsible
for
driving
these
considers
their
impact
on
both
fecundity
(our
fundamental
capacity
to
reproduce).
I
argue
that
because
transition
was
extremely
largely
driven
by
socioeconomic
factors,
it
has
had
lasting
genetic/epigenetic
underpinnings
human
fecundity.
However,
will
be
different.
A
series
conditions
associated
low
societies,
relaxed
selection
pressure
high-fertility
genotypes,
indiscriminate
use
assisted
reproductive
technologies
treat
infertility,
environmental
contamination
toxicants,
may
our
genetic
constitution
ways
compromise
future
species.
Since
any
change
foundations
reproduction
difficult
reverse,
we
should
actively
pursue
methods
monitor
fecundity,
as
sub-replacement
levels
become
established
across
globe.
Genes,
Journal Year:
2023,
Volume and Issue:
14(12), P. 2132 - 2132
Published: Nov. 27, 2023
Infertility
affects
a
significant
number
of
couples
worldwide
and
its
incidence
is
increasing.
While
assisted
reproductive
technologies
(ART)
have
revolutionized
the
treatment
landscape
infertility,
present
with
an
idiopathic
cause
for
their
hindering
effective
management.
Profiling
genome
transcriptome
infertile
men
women
has
revealed
abnormal
gene
expression.
Epigenetic
modifications,
which
comprise
dynamic
processes
that
can
transduce
environmental
signals
into
expression
changes,
may
explain
these
findings.
Indeed,
aberrant
DNA
methylation
been
widely
characterized
as
sperm
oocyte
potentially
deleterious
consequences
on
fertilization
pregnancy
outcomes.
This
review
aims
to
provide
concise
overview
male
female
infertility
through
lens
alterations.
MedComm,
Journal Year:
2025,
Volume and Issue:
6(1)
Published: Jan. 1, 2025
Abstract
The
precise
mechanisms
behind
early
embryonic
arrest
due
to
sperm‐related
factors
and
the
most
effective
strategies
are
not
yet
fully
understood.
Here,
we
present
two
cases
of
male
infertility
linked
novel
TDRD6
variants,
associated
with
oligoasthenoteratozoospermia
(OAT)
arrest.
To
investigate
underlying
promising
therapeutic
approaches,
Tdrd6
knock‐in
knock‐out
mice
were
generated.
variant
demonstrated
OAT
arrest,
mirroring
clinical
observations
our
patients.
Sperm
from
both
affected
individuals
exhibited
aberrant
localization
phospholipase
C
zeta
oocyte
activation
deficiency
(OAD).
application
artificial
(AOA)
effectively
overcame
caused
by
facilitating
successful
pregnancies
live
births
in
human
mice.
Additionally,
research
revealed
that
OAD
influences
expression
multitude
genes
at
2‐pronuclear
(2PN)
stage,
Mos
gene
playing
a
pivotal
role
injection
mRNA
can
mitigate
this
knowledge,
is
first
study
show
affects
2PN
stage
elucidate
how
AOA
overcomes
factor‐derived
enabling
births.
Salud Ciencia y Tecnología,
Journal Year:
2025,
Volume and Issue:
5, P. 1419 - 1419
Published: March 9, 2025
Background:
Assisted
Reproductive
Technology
has
transformed
fertility
treatment
with
new
methods
such
as
Intracytoplasmic
Sperm
Injection
(ICSI),
coming
up
innovative
ways
to
improve
male
fertility.
The
following
paper
compares
the
two
ICSI
techniques,
which
are
mechanical
and
conventional,
on
matters
of
efficiency
in
terms
fertilization.
To
check
for
fertilization,
an
established
morphological
criterion
was
used.
Methods:
This
study
conducted
at
a
clinic
Bocah,
Indonesia,
utilizes
cross-sectional
retrospective
methodology.
analyzes
four
hundred
fifty-eight
oocytes
from
twenty-four
patients
while
focusing
days
one,
three,
five
fertilization
their
success.
Results:
Results
reveal
that
does
better
than
conventional
producing
high-quality
embryos
after
Mechanical
demonstrated
higher
precision,
reduced
oocyte
trauma,
improved
rates
(68.8%
vs.
59.3%
Day
1).
short
span
this
means
success
these
facilitating
carrying
long-term
pregnancy
is
not
evaluated.
It
is,
however,
valuable
note
found
despite
ICSI,
there
qualms
about
moving
towards
large-scale
application
clinics
due
high
costs
involved.
Conclusions:
examined
assisted
reproduction
including
30
individuals
(mean
age:
33.37
years).
yielded
markedly
superior-quality
Days
1,
3,
5.
enhanced
embryo
preservation
results,
underscoring
its
potential
superior
strategy
improving
quality
