Damage mechanisms of bisphenols on the quality of mammalian oocytes DOI Creative Commons

Ashutosh N Pandey,

Pramod K. Yadav, Karuppanan V. Premkumar

et al.

Human Reproduction, Journal Year: 2024, Volume and Issue: unknown

Published: Dec. 20, 2024

Abstract The extensive use of bisphenols in the plastics industry globally is a major growing concern for human health. Bisphenol compounds are easily leached out from plastic containers to food, beverages, and drinking water contaminate natural environment. Daily exposure bisphenol increases their load impairs various organs, including reproductive system. directly or indirectly affect ovarian functions, such as folliculogenesis, steroidogenesis, oogenesis, thereby oocyte quality. A (BPA) its structural analogues act endocrine disruptors induce generation reactive oxygen species (ROS) within ovary. Excess levels ROS death pathways follicular steroidogenic cells steroidogenesis. reduced level estradiol-17β growth development that reduces number quality oocytes. In addition, excess fluid trigger meiotic instability, which further deteriorates high generates oxidative stress triggers germ well oocytes, induces atresia, depletes reserve. Although evidence indicates destructive effects at ovary, potential underlying mechanisms deteriorate remain poorly understood. Therefore, this review summarizes by cause damage impair quality, women's fertility.

Language: Английский

Bisphenol A exposure enhances proliferation and tumorigenesis of papillary thyroid carcinoma through ROS generation and activation of NOX4 signaling pathways DOI Creative Commons
Yi Wang,

Xuling Su,

Qianqian Wang

et al.

Ecotoxicology and Environmental Safety, Journal Year: 2025, Volume and Issue: 292, P. 117946 - 117946

Published: Feb. 27, 2025

Language: Английский

Citations

1
Identification and immunoassay of biomarkers associated with T cell exhaustion in systemic lupus erythematosus DOI Creative Commons
Yiqing Zheng, Hejun Li,

Yanqing Wang

et al.

Frontiers in Immunology, Journal Year: 2025, Volume and Issue: 16

Published: March 26, 2025

Background Systemic lupus erythematosus (SLE) is an autoimmune disease with unclear etiology. T cell exhaustion (TEX) suppresses the immune response and can be a potential therapeutic strategy for diseases. Therefore, this study primarily investigated mechanism by which TEX influences SLE, offering novel target its treatment. Methods GSE72326 GSE81622 were utilized in study. related genes (TEX-RGs) obtained from published literature. Differentially expressed (DEGs) through differential expression analysis. Subsequently, candidate selected overlapping DEGs TEX-RGs. These underwent protein-protein interactions (PPIs) analysis further screening. Machine learning was applied to identify key PPI-identified genes. The exhibiting area under receiver operating characteristic (ROC) curve (AUC) greater than 0.7, along consistent trends significant differences defined as biomarkers. Additionally, enrichment analysis, infiltration chemical compounds prediction molecular docking carried out. Importantly, biomarkers validated reverse transcription-quantitative polymerase chain reaction (RT-qPCR). Results MX1, LY6E, IFI44 OASL screened 327 1,408 Gene set (GSEA) showed that there positive correlation between of these immune-related pathways, such NOD-like receptor signaling pathway, Toll-like pathway RIG-I-like correlation. 8 types cells differed significantly SLE. Naive B cells, resting memory CD4 NK down-regulated SLE group. 4 highest cells. Bisphenol A targeted whereas acetaminophen MX1.The binding activity targeting them very strong. Finally, RT-qPCR results dataset. Conclusion identified could detected blood early diagnosis or monitor efficacy treatment, thus providing new management

Language: Английский

Citations

0
Construction of electron-rich Co centers and abundant redox pairs in MnO2/CoMn2O4 heterointerfaces for PMS activation and water purification DOI
Shuo Wang,

Xingrong Li,

Hongyao Zhao

et al.

Molecular Catalysis, Journal Year: 2025, Volume and Issue: 580, P. 115100 - 115100

Published: April 11, 2025

Language: Английский

Citations

0
The association between urinary BPA concentrations and urinary incontinence in women DOI Creative Commons

Qian Lyu,

Yu Nie,

Jianyong Gao

et al.

Scientific Reports, Journal Year: 2025, Volume and Issue: 15(1)

Published: May 12, 2025

Abstract Urinary incontinence (UI) significantly impacts the quality of life and psychological well-being female patients. Although emerging evidence suggests potential links between endocrine-disrupting chemicals pelvic floor disorders, previous studies on association bisphenol A (BPA) exposure UI in women have yielded inconsistent results. This study aimed to examine this using data from 2015–2016 National Health Nutrition Examination Survey (NHANES) ( n = 467). Through multiple logistic regression analysis with three adjustment models: Model 1 (crude), 2 (adjusted for socio-demographic factors: age, race/ethnicity, education, marital status, poverty ratio), 3 (further adjusted BMI, hypertension, diabetes, alcohol/smoking delivery history), we assessed BPA categorized into quartiles. No significant associations were observed either stress urinary (SUI) or mixed (MUI) across all models P > 0.05). However, participants highest quartile (> 7.6 ng/mg creatinine) exhibited a increased risk urge (UUI) (OR 2.01, 95% CI [1.12–3.63]), 2.04, [1.08–3.85]), 2.48, [1.18–5.20]). has several limitations, including its cross-sectional design, reliance self-reported outcomes, single measurement BPA, residual confounding unmeasured factors. While these findings suggest that environmental may contribute UUI women, future longitudinal repeated biomarker measurements objective assessments are needed confirm observations explore mechanisms. If validated, reducing through public health interventions could emerge as novel preventive strategy UUI.

Language: Английский

Citations

0
Endocrine-disrupting chemicals and female reproductive health: a growing concern DOI
Anne‐Simone Parent, Pauliina Damdimopoulou, Hanna Johansson

et al.

Nature Reviews Endocrinology, Journal Year: 2025, Volume and Issue: unknown

Published: May 22, 2025

Language: Английский

Citations

0
Bisphenols exposure and non-alcoholic fatty liver disease: from environmental trigger to molecular pathogenesis DOI Creative Commons

Changlei Li,

Zhi-Yuan Yao,

Yinfeng Zhang

et al.

Frontiers in Endocrinology, Journal Year: 2025, Volume and Issue: 16

Published: May 22, 2025

Bisphenols (BPs), including bisphenol A (BPA) and its substitutes (BPS, BPF), are ubiquitous environmental contaminants with emerging links to metabolic disorders. This review synthesizes current evidence on the role of BP exposure in pathogenesis non-alcoholic fatty liver disease (NAFLD), a global health crisis affecting 25% adults worldwide. Epidemiological studies reveal significant positive associations between urinary/serum levels NAFLD risk, particularly males, maternal correlating transgenerational dysfunction. Mechanistically, BPs disrupt hepatic lipid homeostasis by activating PPAR-γ suppressing acid oxidation while concurrently inducing insulin resistance via impaired IRS-1/PI3K/Akt signaling. Oxidative stress, NLRP3 inflammasome activation, gut-liver axis perturbations further exacerbate steatosis inflammation. Co-exposure phthalates or high-fat diets amplifies hepatotoxicity, highlighting synergistic risks. Critically, developmental sex-specific susceptibility underscores need for tailored interventions. We propose preventive strategies mitigate progression, avoidance policy reforms. work bridges gaps epidemiology molecular toxicology, emphasizing as modifiable drivers disease.

Language: Английский

Citations

0
Bisphenol A Release from Fiber-Reinforced vs. Conventional Stainless-Steel Fixed Retainers: An In Vitro Study DOI Creative Commons

Efthimia Tsoukala,

Niki C. Maragou,

Andriani-Paraskevi Antonelaki

et al.

Journal of Functional Biomaterials, Journal Year: 2025, Volume and Issue: 16(2), P. 68 - 68

Published: Feb. 17, 2025

The objectives of this study were to investigate in vitro BPA release from two common fiberglass fixed lingual canine-to-canine retainers and compare these amounts with those released a conventional multistranded stainless-steel orthodontic retainer. Fifty-four recently extracted teeth divided into groups six each, formed an arch shape. Three different retainer types evaluated: Ribbond, EverStick Ortho Wildcut wire. identical specimens constructed for each type. was determined validated the liquid chromatography-tandem mass spectrometry method at 1 24 h, as well 7, 14 30 days. method's limits detection quantification 0.32 ng/mL 0.96 ng/mL, respectively. A two-way mixed, repeated-measures analysis variance Greenhouse-Geisser correction employed verify existence any significant differences. Higher levels polyethylene fiber glass comparison present study. differences between systems over time not statistically 95% confidence level. In during first month did differ examined types. highest concentrations observed month.

Language: Английский

Citations

0
The protective role of 3-Indoleglyoxylic acid in Bisphenol S-induced intestinal barrier dysfunction via mitochondrial ROS-Mediated IL-17/CXCL10/TNF-α signaling DOI Creative Commons
Hongbin Wang,

Guolei Niu,

Hai-xing Mai

et al.

Environment International, Journal Year: 2025, Volume and Issue: 199, P. 109477 - 109477

Published: April 17, 2025

Bisphenol S (BPS) has become extensively used in the manufacturing of consumer products. BPS mainly enters body through food and water, with oral exposure targeting gastrointestinal tract. However, its safety profile remains contentious warrants further investigation. In this study, we aimed to assess whether exerts harmful effects on absence overt pathological damage. Our results revealed that although did not lead significant histopathological damage, it induced intestinal barrier dysfunction. Additionally, vitro investigations utilizing NCM460 cells human-derived colorectal organoids demonstrated mitochondrial reactive oxygen species (ROS) levels endocrine (EECs), upregulating expression inflammatory mediators TNF-α CXCL10. Using a DSS-induced colitis mouse model, was found exacerbates progression diseases. Analysis single-cell databases reduction CHGA, functional protein enteroendocrine patients bowel disease (IBD). The CHGA showed negative correlation IL17. Notably, supplementation 3-Indoleglyoxylic acid effectively mitigates damage by BPS. These findings highlight role oxidative stress IL-17/CXCL10/TNF-α signaling BPS-induced demonstrate therapeutic potential mitigating these effects.

Language: Английский

Citations

0
Biological and Behavioural Effects of Bisphenol A (BPA) Exposure: An In Vivo Study in Drosophila melanogaster DOI Creative Commons
Isabel Gaivão, Rita António Santos, Тетяна Морозова

et al.

Applied Sciences, Journal Year: 2025, Volume and Issue: 15(10), P. 5588 - 5588

Published: May 16, 2025

Bisphenol A (BPA) is one of the most produced compounds worldwide. It acts as an endocrine disruptor and can cause adverse effects in body, even at low-dose exposures. By interacting with estrogen receptors, it play important role pathogenesis several diseases, such infertility, hormone-dependent tumours various metabolic disorders. Exposure humans, especially early life, particular concern, since have a big impact on individual’s development growth. The objective this study was to evaluate, vivo, genotoxicity BPA its longevity, prolificacy behaviour Drosophila melanogaster. To evaluate biological behavioural effects, flies were crossed subjected different concentrations (0.5 mM, 1 2 5 mM 10 mM) instant “Carolina” medium hydrated solution for 3 days, then transferred non-treated medium, where they continued lay eggs. This procedure repeated obtain F2 generation. genotoxicity, somatic mutation recombination test (SMART) Comet assays performed. In these cases, higher chosen (1 20 50 mM). results showed that compound caused changes longevity prolificacy, also affected subsequent generations. They Drosophila’s social interaction, but exposure levels investigated here, did not significant genotoxic effects.

Language: Английский

Citations

0
Abnormalities of Oocyte Maturation: Mechanisms and Implications DOI Open Access
Giorgio Maria Baldini, Daniele Ferri, Antonio Malvası

et al.

International Journal of Molecular Sciences, Journal Year: 2024, Volume and Issue: 25(22), P. 12197 - 12197

Published: Nov. 13, 2024

The elucidation of oocyte maturation mechanisms is paramount for advancing embryo development within the scope assisted reproductive technologies (ART). Both cytoplasmic and nuclear represent intricate processes governed by tightly regulated cellular pathways, which are essential ensuring oocyte's competence fertilization subsequent embryogenesis. A comprehensive grasp these vital, as stage significantly influences chromosomal integrity, spindle formation, its ability to support initial stages embryonic development. By leveraging this knowledge, we can enhance in vitro (IVF) protocols, refining ovarian stimulation regimens culture conditions improve quality. This, turn, has potential boost pregnancy rates outcomes. Further research area will contribute novel interventions that aim increase efficacy preimplantation development, offering new opportunities individuals undergoing fertility treatments.

Language: Английский

Citations

2