Internal states as a source of subject-dependent movement variability and their representation by large-scale networks DOI Open Access
Macauley Smith Breault, Pierre Sacré, Zachary Fitzgerald

et al.

bioRxiv (Cold Spring Harbor Laboratory), Journal Year: 2022, Volume and Issue: unknown

Published: Aug. 17, 2022

Abstract A human’s ability to adapt and learn relies on reflecting past performance. Such reflections form latent factors called internal states that induce variability of movement behavior improve Internal are critical for survival, yet their temporal dynamics neural substrates less understood. Here, we link with motor performance activity using state-space models local field potentials captured from depth electrodes in over 100 brain regions. Ten human subjects performed a goal-directed center-out reaching task perturbations applied random trials, causing fail goals reflect Using computational methods, identified two states, indicating kept track errors perturbations, predicted reaction times speed errors. These granted access information indicative how strategize learning trial history, impacting overall We further found large-scale networks differentially encoded these states. The dorsal attention network frequencies above Hz, suggesting role modulating based tracking recent working memory. default below 15 achieving robust an uncertain environment. Moreover, more strongly were functionally connected higher performing subjects, whose strategy was respond by countering opposed accumulating error. Taken together, our findings suggest as basis strategy. regulate variability, through Key points Movement is purposeful process conjured up the enable adaptation learning, both which necessary survival. culmination experiences—collectively referred states—have been implicated during behavioral tasks. To investigate utility control, estimated representation modeled humans simultaneous whole-brain recordings intracranial electrodes. show including states—based error environment uncertainty—improves predictability subject-specific variable reveals related strategies where top performers counter scaled history while bottom maintain tendencies. known Hz but differences between closely modulates exhibits stronger functional connectivity performers. Our involvement orchestrates

Language: Английский

Long-term stability of single neuron activity in the motor system DOI
Kristopher T. Jensen,

Naama Kadmon Harpaz,

Ashesh K. Dhawale

et al.

Nature Neuroscience, Journal Year: 2022, Volume and Issue: 25(12), P. 1664 - 1674

Published: Nov. 10, 2022

Language: Английский

Citations

38
EMPIRICAL STUDY DALAM MENINGKATKAN SEMANGAT KERJA KARYAWAN PT EDS MANUFACTURING INDONESIA BALARAJA-TANGERANG DOI Open Access

Fifi Oktaviani,

Syaechurodji Syaechurodji,

Abdul Wahid Alfarizi

et al.

Jurnal Manajemen dan Bisnis, Journal Year: 2023, Volume and Issue: 5(01), P. 86 - 97

Published: Feb. 28, 2023

Organizations can achieve success through their resources, especially human resources. Therefore, employees become the driving force in making a real contribution to of organization on an ongoing basis. Of course, only with optimal work spirit this success. However, maximize employee performance, there must be strategy improve it. This study aims find out how these strategies morale. The PLS-SEM approach was used study. results indicate that organizational communication as well environment driver increasing morale, either directly or indirectly optimally

Language: Английский

Citations

15
Repeated stress gradually impairs auditory processing and perception DOI Creative Commons

Ghattas Bisharat,

Ekaterina Kaganovski,

Hila Sapir

et al.

PLoS Biology, Journal Year: 2025, Volume and Issue: 23(2), P. e3003012 - e3003012

Published: Feb. 11, 2025

Repetitive stress, a common feature of modern life, is major risk factor for psychiatric and sensory disorders. Despite the prevalence perceptual abnormalities in these disorders, little known about how repetitive stress affects processing perception. Here, we combine mice, longitudinal measurement cortical activity, auditory-guided behaviors to test if sound perception neutral sounds adults are modulated by stress. We found that alters processing, increasing spontaneous activity while dampening sound-evoked responses pyramidal PV cells heightening SST cells. These alterations auditory culminated shifts, particularly reduction loudness Additionally, our work reveals impact on evolves gradually as stressor persists over time, emphasizing dynamic evolving nature this mechanism. Our findings provide insight into possible mechanism which behavior, challenging idea primarily modulates emotionally charged stimuli.

Language: Английский

Citations

0
The Theory of Constructed Emotion: More Than a Feeling DOI
Lisa Feldman Barrett, Shir Atzil, Eliza Bliss‐Moreau

et al.

Perspectives on Psychological Science, Journal Year: 2025, Volume and Issue: 20(3), P. 392 - 420

Published: May 1, 2025

A recently published article by van Heijst et al. attempted to reconcile two research approaches in the science of emotion—basic emotion theory and constructed emotion—by suggesting that former explains emotions as bioregulatory states body whereas latter feelings arise from those state changes. This bifurcation into objective physical subjective involves three misleading simplifications fundamentally misrepresent prevent progress emotion. In this we identify these resulting factual errors, empirical oversights, evolutionary oversimplifications. We then discuss why such errors will continue until scientists realize theories are intrinsically irreconcilable. They rest on incommensurate assumptions require different methods evaluation. Only directly considering differences silos finally dissolve, speeding accumulation trustworthy scientific knowledge about is usable real world.

Language: Английский

Citations

0
Dehydrated Drosophila melanogaster track a water plume in tethered flight DOI Creative Commons

Daniela Limbania,

Grace Turner,

Sara Wasserman

et al.

iScience, Journal Year: 2023, Volume and Issue: 26(3), P. 106266 - 106266

Published: Feb. 25, 2023

Perception of sensory stimuli can be modulated by changes in internal state to drive contextually appropriate behavior. For example, dehydration is a threat terrestrial animals, especially Drosophila melanogaster due their large surface area volume ratio, particularly under the energy demands flight. While hydrated D. avoid water cues, while walking, leads water-seeking We show that tethered flight, flies ignore stimulus, whereas dehydrated track plume. Antennal occlusions eliminate odor and plume tracking, inactivation moist sensing neurons antennae disrupts tracking only upon starvation dehydration. Elimination olfactory coreceptor eradicates leaving behavior intact flies. Our results suggest similar hygrosensory receptors may used for walking in-flight hygrotaxis, temporal dynamics modulating perception vary with behavioral state.

Language: Английский

Citations

6
A perspective on neuroethology: what the past teaches us about the future of neuroethology DOI Creative Commons
M. Jerome Beetz

Journal of Comparative Physiology A, Journal Year: 2024, Volume and Issue: 210(2), P. 325 - 346

Published: Feb. 27, 2024

Abstract For 100 years, the Journal of Comparative Physiology-A has significantly supported research in field neuroethology. The celebration journal’s centennial is a great time point to appreciate recent progress neuroethology and discuss possible avenues field. Animal behavior main source inspiration for neuroethologists. This illustrated by huge diversity investigated behaviors species. To explain at mechanistic level, neuroethologists combine neuroscientific approaches with sophisticated behavioral analysis. rapid technological neuroscience makes highly dynamic exciting research. summarize scientific neuroethology, I went through all abstracts last six International Congresses Neuroethology (ICNs 2010–2022) categorized them based on sensory modalities, experimental model species, topics. highlights gives us perspective field’s future. At end, highlight three topics that may, among others, influence future hope sharing my roots may inspire other scientists follow neuroethological approaches.

Language: Английский

Citations

2
Uncovering multiscale structure in the variability of larval zebrafish navigation DOI Creative Commons
Gautam Sridhar, Massimo Vergassola, João C. Marques

et al.

Proceedings of the National Academy of Sciences, Journal Year: 2024, Volume and Issue: 121(47)

Published: Nov. 15, 2024

Animals chain movements into long-lived motor strategies, exhibiting variability across scales that reflects the interplay between internal states and environmental cues. To reveal structure in such variability, we build Markov models of movement sequences bridge timescales enable a quantitative comparison behavioral phenotypes among individuals. Applied to larval zebrafish responding diverse sensory cues, uncover hierarchy dominated by changes orientation distinguishing cruising versus wandering strategies. Environmental cues induce preferences along these modes at population level: while fish cruise light, they wander response aversive stimuli, or search for appetitive prey. As our method encodes dynamics each individual transitions coarse-grained use it hierarchical phenotypic exploration–exploitation trade-offs. Across wide range major source variation is driven prior and/or immediate exposure prey induces exploitation phenotypes. A large degree not explained unravels hidden override context contrasting Altogether, extracting strategies deployed during navigation, approach exposes individuals reveals tuned experience.

Language: Английский

Citations

2
Missing pieces in decoding the brain oxytocin puzzle: Functional insights from mouse brain wiring diagrams DOI Creative Commons
Steffy B. Manjila, Rebecca Betty, Yongsoo Kim

et al.

Frontiers in Neuroscience, Journal Year: 2022, Volume and Issue: 16

Published: Oct. 26, 2022

The hypothalamic neuropeptide, oxytocin (Oxt), has been the focus of research for decades due to its effects on body physiology, neural circuits, and various behaviors. Oxt elicits a multitude actions mainly through receptor, receptor (OxtR). Despite past understand central projections neurons OxtR- coupled signaling pathways in different brain areas, it remains unclear how this nonapeptide exhibits such pleiotropic while integrating external internal information. Most reviews field either neuroanatomy Oxt-OxtR system, or functional specific areas. Here, we provide review by wide connectivity their downstream circuits with OxtR expression mice. We categorize connected regions into three modules that regulate state, somatic visceral, cognitive response. Each module contains process distinct behavioral effects. Broad innervations (e.g., basal ganglia motor behavior) enable exert coordinated modulation functionally inter-connected circuits. Moreover, acts as neuromodulator neuromodulations broadly control overall state brain. Lastly, discuss mismatch between across mouse In summary, brings forth circuit-based analysis whole light release provides perspective guide future studies.

Language: Английский

Citations

8
The Neurobiology of Parenting and Infant-Evoked Aggression DOI
Harris S. Kaplan, Patricia M. Horvath, Mohammed Mostafizur Rahman

et al.

Physiological Reviews, Journal Year: 2024, Volume and Issue: 105(1), P. 315 - 381

Published: Aug. 15, 2024

Parenting behavior comprises a variety of adult-infant and adult-adult interactions across multiple timescales. The state transition from nonparent to parent requires an extensive reorganization individual priorities physiology is facilitated by combinatorial hormone action on specific cell types that are integrated throughout interconnected brainwide neuronal circuits. In this review, we take comprehensive approach integrate historical current literature each these topics species, with focus rodents. New emerging molecular, circuit-based, computational technologies have recently been used address outstanding gaps in our framework knowledge infant-directed behavior. This work raising fundamental questions about the interplay between instinctive learned components parenting mutual regulation affiliative versus agonistic behaviors health disease. Whenever possible, point how helped gain novel insights opened new avenues research into neurobiology parenting. We hope review will serve as introduction for those field, resource already studying parenting, guidepost designing future studies.

Language: Английский

Citations

1
Brant-X: A Unified Physiological Signal Alignment Framework DOI
D X Zhang, Zhizhang Yuan, Junru Chen

et al.

Proceedings of the 28th ACM SIGKDD Conference on Knowledge Discovery and Data Mining, Journal Year: 2024, Volume and Issue: unknown, P. 4155 - 4166

Published: Aug. 24, 2024

Physiological signals serve as indispensable clues for understanding various physiological states of human bodies. Most existing works have focused on a single type range application scenarios. However, the body is holistic biological system, inherent interconnection among data should not be neglected. In particular, given brain's role control center vital activities, electroencephalogram (EEG) exhibits significant correlations with other signals. Therefore, correlation between EEG and holds potential to improve performance in Nevertheless, achieving this goal still constrained by several challenges: scarcity simultaneously collected data, differences signals, tasks. To address these issues, we propose unified signal alignment framework, Brant-X, model Our approach (1) employs foundation data-efficiently transfer rich knowledge (2) introduces two-level fully align semantics from different semantic scales. experiments, Brant-X achieves state-of-the-art compared task-agnostic task-specific baselines downstream tasks diverse scenarios, including sleep stage classification, emotion recognition, freezing gaits detection, eye movement communication. Moreover, analysis arrhythmia detection task visualization case study further illustrate effectiveness The model's homepage at https://github.com/zjunet/Brant-X/.

Language: Английский

Citations

1