Effects of the LINC00641/miR-323a-3p/EIF4G2 axis on behaviors and brain monoamine neurotransmitters in chronic unpredictable mild stress mice DOI Creative Commons
Lin Zhou, Qi Dong, Yongbo Zhang

et al.

Cell Biology and Toxicology, Journal Year: 2025, Volume and Issue: 41(1)

Published: April 28, 2025

This paper aimed to probe the role of LINC00641/miR-323a-3p/EIF4G2 axis in regulating behavioral and brain monoamine neurotransmitter levels a mouse model depression induced by chronic unpredictable mild stress (CUMS). A CUMS-induced was established mice. series tests, comprising sucrose preference, tail suspension, as well forced swimming were conducted. Levels LINC00641, miR-323a-3p, EIF4G2 hippocampal tissues measured. Biochemical indices, including 5-HT, NE, DA, analyzed. Hippocampal neuron structure apoptosis evaluated. The targeting relationship among validated experimentally. CUMS mice exhibited reduced prolonged immobilization time decreased DA levels, increased apoptosis. Overexpression LINC00641 or knockdown miR-323a-3p significantly alleviated depression-like behaviors restored levels. regulated expression while also modulated through LINC00641. Upregulation improves enhances neurotransmission via miR-323a-3p/EIF4G2 axis, underscoring its potent therapeutic target for depression.

Language: Английский

Genetic, Epigenetic, and Hormonal Regulation of Stress Phenotypes in Major Depressive Disorder: From Maladaptation to Resilience DOI Creative Commons

Anushka Arvind,

S Sreelekshmi,

Neelima Dubey

et al.

Cellular and Molecular Neurobiology, Journal Year: 2025, Volume and Issue: 45(1)

Published: March 26, 2025

Language: Английский

Citations

0
Epigenetic changes caused by early life stress in the pathogenesis of depression DOI
Hongsheng Bi,

Jingyan Jin,

Mingyuan Sun

et al.

European Journal of Pharmacology, Journal Year: 2025, Volume and Issue: unknown, P. 177671 - 177671

Published: April 1, 2025

Language: Английский

Citations

0
Effects of the LINC00641/miR-323a-3p/EIF4G2 axis on behaviors and brain monoamine neurotransmitters in chronic unpredictable mild stress mice DOI Creative Commons
Lin Zhou, Qi Dong, Yongbo Zhang

et al.

Cell Biology and Toxicology, Journal Year: 2025, Volume and Issue: 41(1)

Published: April 28, 2025

This paper aimed to probe the role of LINC00641/miR-323a-3p/EIF4G2 axis in regulating behavioral and brain monoamine neurotransmitter levels a mouse model depression induced by chronic unpredictable mild stress (CUMS). A CUMS-induced was established mice. series tests, comprising sucrose preference, tail suspension, as well forced swimming were conducted. Levels LINC00641, miR-323a-3p, EIF4G2 hippocampal tissues measured. Biochemical indices, including 5-HT, NE, DA, analyzed. Hippocampal neuron structure apoptosis evaluated. The targeting relationship among validated experimentally. CUMS mice exhibited reduced prolonged immobilization time decreased DA levels, increased apoptosis. Overexpression LINC00641 or knockdown miR-323a-3p significantly alleviated depression-like behaviors restored levels. regulated expression while also modulated through LINC00641. Upregulation improves enhances neurotransmission via miR-323a-3p/EIF4G2 axis, underscoring its potent therapeutic target for depression.

Language: Английский

Citations

0