Expert Opinion on Pharmacotherapy, Journal Year: 2025, Volume and Issue: unknown
Published: May 15, 2025
Opioid use disorder (OUD) is recognized as a chronic, relapsing with high mortality and psychiatric somatic comorbidity. Existing guidelines meta-analyses on pharmacotherapy of opioid were reviewed. maintenance treatment (OMT) the generally accepted first line in OUD oral methadone buprenorphine being gold standard. In recent years number novel opioids have been introduced into clinical practice including depot formulations buprenorphine, retarded morphine heroin (diacetylmorphine). The review refers to different drugs available gives an overview use, side effects, efficacy certain subgroups. OMT success story emerging new pharmacological options available. While or still are most suitable medications for many patients, may improve adherence facilitate management patients. Diacetylmorphine second refractory Future research focus responder characteristics special subgroups well interaction psychosocial treatments.
Language: Английский