Differential gene expression in PBMCs: Insights into the mechanism how pulmonary tuberculosis increases lung cancer risk DOI Creative Commons
Jie Wu, Yang Chen, Xiaoqi Yang

et al.

Gene, Journal Year: 2024, Volume and Issue: 940, P. 149199 - 149199

Published: Dec. 27, 2024

Pre-existing of pulmonary tuberculosis (PTB) poses increased lung cancer risk, yet the molecular mechanisms remain inadequately understood. This study sought to elucidate potential by performing comprehensive analyses differentially expressed genes (DEGs) in peripheral blood mononuclear cells (PBMCs) from patients with PTB, adenocarcinoma (LUAD), and squamous cell carcinoma (LUSC). Microarray assays were employed analyze DEGs PBMCs these patients. The revealed that, compared healthy controls, number LncRNA LUAD, LUSC 801, 8,541, 7,796, respectively. Similarly, mRNA 629, 4,865, 4,438, These transcripts represent significant resources for identifying diagnostic differential biomarkers PTB. Pathways enriched dysregulated mRNAs identified through GO KEGG pathway analyses. results indicated that 9 pathways including NOD-like receptor signaling pathway, cancer, MAPK co-enriched across groups, providing insights into which PTB may increase risk development progression.

Language: Английский

Progranulin inhibits autophagy to facilitate intracellular colonization of Helicobacter pylori through the PGRN/mTOR/DCN axis in gastric epithelial cells DOI Creative Commons
Linlin Liu, Miao Xiang, Jiaqi Zhou

et al.

Frontiers in Cellular and Infection Microbiology, Journal Year: 2024, Volume and Issue: 14

Published: July 31, 2024

(

Citations

3
The Role of mTOR in Mycobacterium tuberculosis Infection DOI Creative Commons
Ami Patel,

L Nguyen,

Christina Shea

et al.

Biomedicines, Journal Year: 2024, Volume and Issue: 12(10), P. 2238 - 2238

Published: Oct. 1, 2024

:

Citations

0
Differential gene expression in PBMCs: Insights into the mechanism how pulmonary tuberculosis increases lung cancer risk DOI Creative Commons
Jie Wu, Yang Chen, Xiaoqi Yang

et al.

Gene, Journal Year: 2024, Volume and Issue: 940, P. 149199 - 149199

Published: Dec. 27, 2024

Pre-existing of pulmonary tuberculosis (PTB) poses increased lung cancer risk, yet the molecular mechanisms remain inadequately understood. This study sought to elucidate potential by performing comprehensive analyses differentially expressed genes (DEGs) in peripheral blood mononuclear cells (PBMCs) from patients with PTB, adenocarcinoma (LUAD), and squamous cell carcinoma (LUSC). Microarray assays were employed analyze DEGs PBMCs these patients. The revealed that, compared healthy controls, number LncRNA LUAD, LUSC 801, 8,541, 7,796, respectively. Similarly, mRNA 629, 4,865, 4,438, These transcripts represent significant resources for identifying diagnostic differential biomarkers PTB. Pathways enriched dysregulated mRNAs identified through GO KEGG pathway analyses. results indicated that 9 pathways including NOD-like receptor signaling pathway, cancer, MAPK co-enriched across groups, providing insights into which PTB may increase risk development progression.

Language: Английский

Citations

0