Recent advances in chemical synthesis of phosphodiester linkages found in fungal mannans DOI Creative Commons
Zuchao Ma,

Harry E. Ensley,

Douglas W. Lowman

et al.

Carbohydrate Research, Journal Year: 2024, Volume and Issue: 547, P. 109325 - 109325

Published: Nov. 22, 2024

Language: Английский

Differential structure and immunomodulatory functions of lipophosphoglycan between Leishmania spp DOI Creative Commons
Lisa U. Teufel, Leo A. B. Joosten, Jéssica Cristina dos Santos

et al.

Immunology Letters, Journal Year: 2024, Volume and Issue: 268, P. 106885 - 106885

Published: June 18, 2024

Leishmaniasis is a collective term for several tropical, neglected diseases caused by protozoans of the species Leishmania, 20 which causing disease in humans ranging from localised self-healing lesions to chronic manifestations affect skin or inner organs. Although millions infections are accounted annually, treatment options scarce and limited medication associated with heavy side-effects increasing antibiotic resistance. Case studies point towards immunotherapy as effective alternative relying on immunomodulatory properties e.g., Bacillus Calmette-Guérin vaccine. Leishmania parasites also known modulate immune system, yet underlying macromolecules surface molecules remain widely under characterised. With this short review, we aim provide complete summary existing literature describing one most expressed molecule spp, lipophosphoglycan (LPG), shows great variability between different lifecycle stages spp. Complete characterisation LPG may aid improve development vaccination strategies, open new avenues exploit unrelated conditions.

Language: Английский

Citations

4
The Dectin-1 and Dectin-2 clusters: C-type lectin receptors with fundamental roles in immunity DOI Creative Commons
Mariano Malamud, Gordon D. Brown

EMBO Reports, Journal Year: 2024, Volume and Issue: unknown

Published: Oct. 31, 2024

Language: Английский

Citations

4
“Mannose glycans as key players in trained immunity: A novel anti-tumoral catalyst” DOI Creative Commons
Pedro Milanez‐Almeida, Inês Alves, Ângela Fernandes

et al.

Biochimica et Biophysica Acta (BBA) - General Subjects, Journal Year: 2025, Volume and Issue: unknown, P. 130779 - 130779

Published: Feb. 1, 2025

Language: Английский

Citations

0
“Glycans in Trained Immunity: educators of innate immune memory in homeostasis and disease” DOI Creative Commons
Pedro Milanez‐Almeida, Ângela Fernandes, Inês Alves

et al.

Carbohydrate Research, Journal Year: 2024, Volume and Issue: 544, P. 109245 - 109245

Published: Aug. 22, 2024

Trained Immunity is defined as a biological process normally induced by exogenous or endogenous insults that triggers epigenetic and metabolic reprogramming events associated with long-term adaptation of innate immune cells. This trained phenotype confers enhanced responsiveness to subsequent triggers, resulting in an "memory" effect. Immunity, the past decade, has revealed important benefits for host defense homeostasis, but can also induce potentially harmful outcomes chronic inflammatory disorders autoimmune diseases. Interestingly, evidence suggest "trainers" prompting immunity are frequently glycans structures. In fact, exposure different types at surface pathogens key driver training phenotype, leading cells through recognition those glycan-triggers variety glycan-binding proteins (GBPs) expressed β-glucan mannose-enriched structures Candida albicans some examples highlight potential immunity, both homeostasis disease. this review, we will discuss relevance exposed establishing immunological hubs glycan-recognizing receptors cells, highlighting how glycan-GBP network impact immunity. Finally, power GBPs targets envisioning therapeutic applications.

Language: Английский

Citations

1
A preliminary investigation on the protective effects of β-glucan and mannan induced trained immunity in pufferfish Takifugu obscurus DOI

Xiaorui Song,

Tianying Lei,

Nan Cui

et al.

Fish & Shellfish Immunology, Journal Year: 2024, Volume and Issue: 156, P. 110035 - 110035

Published: Nov. 20, 2024

Language: Английский

Citations

1
Analysis of the potential long-lasting effects of probiotic Debaryomyces hansenii CBS 8339 on trained immunity in newborn goats DOI
Miriam Angulo, Carlos Angulo

Developmental & Comparative Immunology, Journal Year: 2024, Volume and Issue: 162, P. 105292 - 105292

Published: Nov. 20, 2024

Language: Английский

Citations

1
Candida tropicalis PMT2 Is a Dispensable Gene for Viability but Required for Proper Interaction with the Host DOI Creative Commons

Marco J. Hernández-Chávez,

Iván Martínez-Duncker,

Diana M. Clavijo-Giraldo

et al.

Journal of Fungi, Journal Year: 2024, Volume and Issue: 10(7), P. 502 - 502

Published: July 20, 2024

Candidemia is an opportunistic mycosis with high morbidity and mortality rates. Even though

Language: Английский

Citations

0
Trained immunity: a revolutionary immunotherapeutic approach DOI Creative Commons
Md. Salauddin, Sabuj Kanti Nath, Sukumar Saha

et al.

Animal Diseases, Journal Year: 2024, Volume and Issue: 4(1)

Published: Sept. 14, 2024

Abstract Trained immunity is a phenomenon in which brief exposure to an infectious agent or vaccine can induce long-lasting changes the host's immune system, enhancing protection against subsequent infections. The concept of trained has significant impact on field immunology and potential revolutionize how we approach vaccination disease control. Investigations into are rapidly advancing have led development new vaccines immunotherapeutic strategies that harness power this phenomenon. While more investigations needed fully understand mechanisms its limitations, prospects for future application clinical practice promising. Here, describe as biological process explore innate cues, epigenetic changes, metabolic reprogramming activities affect induced.

Language: Английский

Citations

0
Recent advances in chemical synthesis of phosphodiester linkages found in fungal mannans DOI Creative Commons
Zuchao Ma,

Harry E. Ensley,

Douglas W. Lowman

et al.

Carbohydrate Research, Journal Year: 2024, Volume and Issue: 547, P. 109325 - 109325

Published: Nov. 22, 2024

Language: Английский

Citations

0