Advanced Journal of Graduate Research, Journal Year: 2025, Volume and Issue: 16(1), P. 23 - 37
Published: April 5, 2025
The human immunodeficiency virus (HIV) is a major worldwide health concern, affecting millions of people globally, and when untreated progresses into acquired immune deficiency syndrome (AIDS). With the availability antiretroviral therapy (ART), HIV infection defined as manageable, but not curable, chronic condition. ART inhibits viral replication prevents transmission does eliminate due to latency in memory T cells, exacerbated by rise drug resistant mutations (DRMs), so lifelong treatment monitoring required. In this review, we discuss justifications research approaches towards finding “cure” for i.e. complete elimination or control without need further treatment. two main barriers developing cure are property high mutation rate virus. A few cases have been cured through bone marrow transplants treat acute myeloid leukaemia, where donors had rare CCR5 gene, required entry. More viable include “Shock Kill” method which aims use reverse allowing these cells be detected destroyed with ART, “Block Lock” block transcription HIV-infected latent preventing rebound after cessation ART. possibility vaccination has widely explored, an effective vaccine yet developed more than 40 years pandemic. Currently, appear most favourable, possibly conjunction other recently interventions such passive immunisation broadly neutralizing antibodies. However, taken develop cannot detached from ethical concerns acknowledged navigated.
Language: Английский