Antimicrobial Stewardship Impact on Antibiotic Use in Three Tertiary Hospitals in Zambia: A Comparative Point Prevalence Survey DOI Creative Commons
Steward Mudenda,

Kenneth Kapolowe,

Uchizi Chirwa

et al.

Antibiotics, Journal Year: 2025, Volume and Issue: 14(3), P. 284 - 284

Published: March 10, 2025

Introduction: Antimicrobial stewardship (AMS) can improve the rational use of antibiotics in hospitals. This study assessed impact a multifaceted AMS intervention on antibiotic and prescribing patterns at three tertiary hospitals Zambia. Methods: Point Prevalence Surveys (PPS) were conducted August 2022 October 2023. It was part 3-year demonstration project that aimed to optimize treating urinary tract infections (UTIs) bloodstream (BSIs) various health sector settings Up 170 medical records 265 2023 included assessment. Results: Overall, prevalence this PPS 75%. Eighty-one percent (81%) 71% patients least one 2023, respectively, indicating decrease 10%. Similarly, ceftriaxone, most prescribed antibiotic, declined from an average 48% 38% Adherence Standard Treatment Guidelines (STGs) slightly increased 42% 45% Additionally, reduced 1.38 1.21. Conclusions: had early positive adherence Guidelines.

Language: Английский

Prevalence of multidrug-resistant bacteria in healthcare and community settings in West Africa: systematic review and meta-analysis DOI Creative Commons

Moustapha Diop,

Oumar Bassoum, Abdourahmane Ndong

et al.

BMC Infectious Diseases, Journal Year: 2025, Volume and Issue: 25(1)

Published: Feb. 28, 2025

Multidrug-resistant (MDR) bacteria are a global health threat, notably in low- and middle-income countries. The aim of this review was to estimate the prevalence multidrug-resistant healthcare community settings West Africa. In accordance with PRISMA guidelines, we searched PubMed, CINAHL, African Index Medicus, other databases for studies published from 2010 onward. Data on MDR bacterial prevalence, study characteristics, infection types were extracted analyzed via R software. Subgroup analyses performed explore differences across sample types. Out 5,320 articles identified, 50 13 countries met inclusion criteria, majority Nigeria (34%) Ghana (22%). Among 35,820 isolated these studies, gram-negative (GNB), particularly Escherichia coli Klebsiella sp., most frequently species, accounting 63.3% bacteria. overall 59% (95% CI: 48-69%), significant heterogeneity between (I² = 98%, p < 0.001). analysis revealed 7% increase first five-year period last two periods, greater nosocomial infections (65%, 95% 45-81%) than community-acquired (53%, 31-74%). mixed 58% 44-71%). highest urine samples (72%, 57-84%) superficial skin (69%, 29-92%), whereas it lowest nasopharyngeal (26%, 21-33%). high Africa underscores need strengthened control measures, improved surveillance, stricter antibiotic use policies. Enhanced regional collaboration is essential mitigate spread AMR both settings. CRD42023470363.

Language: Английский

Citations

0

Antimicrobial Stewardship Impact on Antibiotic Use in Three Tertiary Hospitals in Zambia: A Comparative Point Prevalence Survey DOI Creative Commons
Steward Mudenda,

Kenneth Kapolowe,

Uchizi Chirwa

et al.

Antibiotics, Journal Year: 2025, Volume and Issue: 14(3), P. 284 - 284

Published: March 10, 2025

Introduction: Antimicrobial stewardship (AMS) can improve the rational use of antibiotics in hospitals. This study assessed impact a multifaceted AMS intervention on antibiotic and prescribing patterns at three tertiary hospitals Zambia. Methods: Point Prevalence Surveys (PPS) were conducted August 2022 October 2023. It was part 3-year demonstration project that aimed to optimize treating urinary tract infections (UTIs) bloodstream (BSIs) various health sector settings Up 170 medical records 265 2023 included assessment. Results: Overall, prevalence this PPS 75%. Eighty-one percent (81%) 71% patients least one 2023, respectively, indicating decrease 10%. Similarly, ceftriaxone, most prescribed antibiotic, declined from an average 48% 38% Adherence Standard Treatment Guidelines (STGs) slightly increased 42% 45% Additionally, reduced 1.38 1.21. Conclusions: had early positive adherence Guidelines.

Language: Английский

Citations

0