Prevalence of multidrug-resistant bacteria in healthcare and community settings in West Africa: systematic review and meta-analysis
BMC Infectious Diseases,
Journal Year:
2025,
Volume and Issue:
25(1)
Published: Feb. 28, 2025
Multidrug-resistant
(MDR)
bacteria
are
a
global
health
threat,
notably
in
low-
and
middle-income
countries.
The
aim
of
this
review
was
to
estimate
the
prevalence
multidrug-resistant
healthcare
community
settings
West
Africa.
In
accordance
with
PRISMA
guidelines,
we
searched
PubMed,
CINAHL,
African
Index
Medicus,
other
databases
for
studies
published
from
2010
onward.
Data
on
MDR
bacterial
prevalence,
study
characteristics,
infection
types
were
extracted
analyzed
via
R
software.
Subgroup
analyses
performed
explore
differences
across
sample
types.
Out
5,320
articles
identified,
50
13
countries
met
inclusion
criteria,
majority
Nigeria
(34%)
Ghana
(22%).
Among
35,820
isolated
these
studies,
gram-negative
(GNB),
particularly
Escherichia
coli
Klebsiella
sp.,
most
frequently
species,
accounting
63.3%
bacteria.
overall
59%
(95%
CI:
48-69%),
significant
heterogeneity
between
(I²
=
98%,
p
<
0.001).
analysis
revealed
7%
increase
first
five-year
period
last
two
periods,
greater
nosocomial
infections
(65%,
95%
45-81%)
than
community-acquired
(53%,
31-74%).
mixed
58%
44-71%).
highest
urine
samples
(72%,
57-84%)
superficial
skin
(69%,
29-92%),
whereas
it
lowest
nasopharyngeal
(26%,
21-33%).
high
Africa
underscores
need
strengthened
control
measures,
improved
surveillance,
stricter
antibiotic
use
policies.
Enhanced
regional
collaboration
is
essential
mitigate
spread
AMR
both
settings.
CRD42023470363.
Language: Английский
Antimicrobial Stewardship Impact on Antibiotic Use in Three Tertiary Hospitals in Zambia: A Comparative Point Prevalence Survey
Steward Mudenda,
No information about this author
Kenneth Kapolowe,
No information about this author
Uchizi Chirwa
No information about this author
et al.
Antibiotics,
Journal Year:
2025,
Volume and Issue:
14(3), P. 284 - 284
Published: March 10, 2025
Introduction:
Antimicrobial
stewardship
(AMS)
can
improve
the
rational
use
of
antibiotics
in
hospitals.
This
study
assessed
impact
a
multifaceted
AMS
intervention
on
antibiotic
and
prescribing
patterns
at
three
tertiary
hospitals
Zambia.
Methods:
Point
Prevalence
Surveys
(PPS)
were
conducted
August
2022
October
2023.
It
was
part
3-year
demonstration
project
that
aimed
to
optimize
treating
urinary
tract
infections
(UTIs)
bloodstream
(BSIs)
various
health
sector
settings
Up
170
medical
records
265
2023
included
assessment.
Results:
Overall,
prevalence
this
PPS
75%.
Eighty-one
percent
(81%)
71%
patients
least
one
2023,
respectively,
indicating
decrease
10%.
Similarly,
ceftriaxone,
most
prescribed
antibiotic,
declined
from
an
average
48%
38%
Adherence
Standard
Treatment
Guidelines
(STGs)
slightly
increased
42%
45%
Additionally,
reduced
1.38
1.21.
Conclusions:
had
early
positive
adherence
Guidelines.
Language: Английский