Prognostic significance of a signature based on senescence-related genes in colorectal cancer

GeroScience, Journal Year: 2024, Volume and Issue: 46(5), P. 4495 - 4504

Published: April 25, 2024

Colorectal cancer, recognized as a quintessential age-related disease, underscores the intricate interplay between aging mechanisms and disease pathogenesis. Cellular senescence, DNA damage-induced cellular stress response, is characterized by cell cycle arrest, expression of an inflammatory senescence-associated secretory phenotype, alterations in extracellular matrix metabolism. It widely fundamental evolutionarily conserved mechanism aging. Guided geroscience principles, which assert that pathogenesis diseases involves aging, this study delves into role senescence-related genes colon cancer progression. Leveraging gene set reflective pathways, we employed uni- multivariate Cox proportional hazards survival analysis combined with determination false discovery rate to analyze correlations survival. The integrated database 1130 specimens available relapse-free time relapse event data from ten independent cohorts provided robust platform for analyses. We identified associated differential levels linked shorter Our findings unveil prognostic signature utilizing (hazard ratio: 2.73, 95% CI 2.12-3.52, p = 6.4E - 16), offering valuable insights prediction cancer. Multivariate underscored independence epidemiological pathological variables. This highlights potential biomarkers. Overall, our results underscore pivotal

Language: Английский

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Senescence-related genes as prognostic indicators in breast cancer survival

GeroScience, Journal Year: 2024, Volume and Issue: unknown

Published: Oct. 21, 2024

Abstract Breast cancer is a leading cause of cancer-related mortality among women worldwide, particularly affecting those in their later years. As the incidence breast increases with age, understanding biological mechanisms that link aging and becomes crucial. Cellular senescence, hallmark aging, plays dual role by inhibiting tumorigenesis while also contributing to tumor progression through senescence-associated secretory phenotype (SASP). This study aims investigate prognostic significance senescence-related genes cancer. We utilized SenMayo gene list, comprehensive set genes, analyze expression data from large cohort samples. The was sourced Kaplan–Meier plotter, an integrated database compiles information multiple independent cohorts. Cox proportional hazards regression false discovery rate (FDR) corrections were employed evaluate correlation between survival outcomes, aiming establish signature. Our findings demonstrate higher levels are significantly associated improved survival, lower correlate shorter outcomes. These results suggest pathways play protective cancer, potentially serving as valuable indicators. identification signature based on underscores importance cellular senescence survival. highlights potential biomarkers enhancing patient stratification informing treatment strategies, growing body literature intersection

Language: Английский

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Chemo-Senolytic Therapeutic Potential against Angiosarcoma

Journal of Investigative Dermatology, Journal Year: 2024, Volume and Issue: 144(10), P. 2285 - 2297.e13

Published: April 2, 2024

Angiosarcoma is an aggressive soft-tissue sarcoma with a poor prognosis. Chemotherapy for this cancer typically employs paclitaxel, taxane (genotoxic drug), although it has limited effect owing to chemoresistance prolonged treatment. In study, we examine alternative angiosarcoma treatment approach that combines chemotherapeutic and senolytic agents. We find the drugs cisplatin paclitaxel efficiently induce senescence in cells. Subsequent agent ABT-263 eliminates senescent cells by activating apoptotic pathway. addition, expression analysis indicates senescence-associated secretory phenotype genes are activated downregulates IFN-I pathway Moreover, show alone requires high doses remove contrast, lower of sufficient senescence, followed elimination This study sheds light on potential therapeutic strategy against combining relatively low dose agent, which can help ease deleterious side effects chemotherapy.

Language: Английский

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CHIP and aging: a key regulator of proteostasis and cellular senescence

Biogerontology, Journal Year: 2025, Volume and Issue: 26(3)

Published: May 5, 2025

Language: Английский

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Cardiac glycosides: Looking beyond heart failure and atrial fibrillation

Indian Journal of Pharmacology, Journal Year: 2025, Volume and Issue: 57(1), P. 33 - 47

Published: Jan. 1, 2025

Language: Английский

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RNA-Seq Reveals the Mechanism of Pyroptosis Induced by Oxygen-Enriched IR780 Nanobubbles-Mediated Sono-Photodynamic Therapy

International Journal of Nanomedicine, Journal Year: 2024, Volume and Issue: Volume 19, P. 13029 - 13045

Published: Dec. 1, 2024

Sono-photodynamic therapy (SPDT), the combination of sonodynamic (SDT) and photodynamic (PDT), is a promising tumor treatment method. However, hypoxic microenvironment greatly compromises efficacy SPDT. Pyroptosis, new type programmed cell death, mainly induced by some chemotherapeutic drugs in current research, rarely RNA sequencing (RNA-seq) high-throughput technique that comprehensively profiles transcriptome, revealing full spectrum molecules cell. Here, we constructed IR780@O

Language: Английский

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Host Defense Peptides: Exploiting an Innate Immune Component Against Infectious Diseases and Cancer

International Journal of Peptide Research and Therapeutics, Journal Year: 2024, Volume and Issue: 30(6)

Published: Oct. 5, 2024

Language: Английский

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