LIM domain proteins in cell mechanobiology DOI Creative Commons
Caitlin A. Anderson, David R. Kovar, Margaret L. Gardel

et al.

Cytoskeleton, Journal Year: 2021, Volume and Issue: 78(6), P. 303 - 311

Published: May 24, 2021

The actin cytoskeleton is important for maintaining mechanical homeostasis in adherent cells, largely through its regulation of adhesion and cortical tension. LIM (Lin-11, Isl1, MEC-3) domain-containing proteins are involved a myriad cellular mechanosensitive pathways. Recent work has discovered that domains bind to mechanically stressed filaments, suggesting novel widely conserved mechanism mechanosensing. This review summarizes the current state knowledge protein mechanosensitivity.

Language: Английский

Growth-induced stress enhances epithelial-mesenchymal transition induced by IL-6 in clear cell renal cell carcinoma via the Akt/GSK-3β/β-catenin signaling pathway DOI Creative Commons
Qiwei Chen, Deyong Yang, Hong Zong

et al.

Oncogenesis, Journal Year: 2017, Volume and Issue: 6(8), P. e375 - e375

Published: Aug. 28, 2017

Stromal cell populations in the tumor microenvironment (TME) play a critical role oncogenesis and metastasis of renal carcinoma. In this study, we found that there are α-smooth muscle actin positive (α-SMA (+)) cells stroma clear carcinoma (ccRCC) tissues, their numbers significantly associated with poor survival ccRCC patients. Interleukin 6 (IL-6) is diver induces α-SMA (+) tissues via promotion epithelial to mesenchymal transition (EMT) stimulates migration invasion ccRCC. Peritumoral CD4+ T main source IL-6 tissues. addition biochemical factors, mechanical compression within tumors affects behavior. Tumors grown confined space exhibit intratumoral compressive stress and, sufficient pressure, stress-stimulated cancer cells. Moreover, combination secreted by growth-induced solid further contributes regulation morphogenesis, EMT acquisition stemness phenotype. The effects group were driven Akt/GSK-3β/β-catenin signaling pathway, deregulation β-catenin expression was predictive outcome Notably, stem marker, CD44, correlated stage, high Fuhrman grade These data provide evidence for new stress-reducing targeting strategies therapy.

Language: Английский

Citations

69
A coupled bulk-surface model for cell polarisation DOI
Davide Cusseddu, Leah Edelstein‐Keshet, J.A. Mackenzie

et al.

Journal of Theoretical Biology, Journal Year: 2018, Volume and Issue: 481, P. 119 - 135

Published: Sept. 8, 2018

Language: Английский

Citations

64
Cell engineering: Biophysical regulation of the nucleus DOI
Yang Song, Jennifer Soto,

Binru Chen

et al.

Biomaterials, Journal Year: 2020, Volume and Issue: 234, P. 119743 - 119743

Published: Jan. 3, 2020

Language: Английский

Citations

51
Self-organized patterning of cell morphology via mechanosensitive feedback DOI Creative Commons
Natalie A. Dye, Marko Popović, K. Venkatesan Iyer

et al.

eLife, Journal Year: 2021, Volume and Issue: 10

Published: March 26, 2021

Tissue organization is often characterized by specific patterns of cell morphology. How such emerge in developing tissues a fundamental open question. Here, we investigate the emergence tissue-scale shape and mechanical tissue stress

Language: Английский

Citations

48
LIM domain proteins in cell mechanobiology DOI Creative Commons
Caitlin A. Anderson, David R. Kovar, Margaret L. Gardel

et al.

Cytoskeleton, Journal Year: 2021, Volume and Issue: 78(6), P. 303 - 311

Published: May 24, 2021

The actin cytoskeleton is important for maintaining mechanical homeostasis in adherent cells, largely through its regulation of adhesion and cortical tension. LIM (Lin-11, Isl1, MEC-3) domain-containing proteins are involved a myriad cellular mechanosensitive pathways. Recent work has discovered that domains bind to mechanically stressed filaments, suggesting novel widely conserved mechanism mechanosensing. This review summarizes the current state knowledge protein mechanosensitivity.

Language: Английский

Citations

48