Impact of Hypoxia on Alveolar Bone Dynamics and Remodeling DOI Creative Commons
Sangeetha Narasimhan, Sausan Al Kawas, Shishir Shetty

et al.

Heliyon, Journal Year: 2024, Volume and Issue: 10(23), P. e40868 - e40868

Published: Dec. 1, 2024

Oxygen is a fundamental requirement for cellular metabolism. Hypoxia state of oxygen deprivation the tissues. Cells develop numerous adaptive mechanisms to survive hypoxic insult. Alveolar bone unique structure that encases and protects tooth. Literature reports hypoxia, in all forms, impacts alveolar health. The hypoxia-inducible pathway appears play key role mediating changes Embryonic hypoxia plays vital craniofacial skeletal development. Further, has been anticipated repair extraction sockets. cells respond distinctly conditions with both beneficial detrimental effects. Studies have demonstrated enhanced resorption upon stimuli. However, also shown potential therapeutic effects on by triggering an angiogenic response. Additionally, type, duration, mode are critical varied responses main objective this review recapitulate different types tooth supporting apparatus analyze some presumptive underlying hypoxia-induced remodeling.

Language: Английский

Estrogen and estrogen receptors mediate the mechanobiology of bone disease and repair DOI
Vivian Y. Shi, Elise F. Morgan

Bone, Journal Year: 2024, Volume and Issue: 188, P. 117220 - 117220

Published: Aug. 5, 2024

Language: Английский

Citations

11
Piezo Channels in Dentistry: Decoding the Functional Effects of Forces DOI

Jr-Ming Lai,

Qiuyu Wu, Boxiong Gao

et al.

Journal of Dental Research, Journal Year: 2025, Volume and Issue: unknown

Published: May 12, 2025

The oral system is a highly complex mechanosensory structure that continuously adapts to changes in mechanical stimuli, exerting forces on cells and tissues. Understanding how these are converted into biochemical signals they mediate gene expression cellular activities has been significant focus dentistry. Piezo channels, including Piezo1 Piezo2, mechanically activated cation channels characterized by an extracellular “cap” domain 3 peripheral mechanosensitive blades. Recent research demonstrated applied tissues can induce deformation of cell membranes, leading conformational facilitate influx, thereby regulating activities. influx Ca 2 + , the most discussed outcome channel activation, initiates diverse signaling pathways regulate dentin hypersensitivity, alveolar bone remodeling, temporomandibular joint (TMJ) osteoarthritis. chemical inhibition shown alleviate dentinal reduce rate orthodontic tooth movement, slow progression TMJ osteoarthritis rat models. Mice deficient piezo exhibit impaired reactive formation, reduced volume, developmental deformities jawbone. Considering their roles decoding functional effects forces, this review summarizes involvement dentistry, organized anatomical sites, provide comprehensive knowledge mediated signal crosstalk, which offers promising therapeutic prospects for treatment various force-related diseases.

Language: Английский

Citations

0
The impact of curculigoside on osteogenic differentiation and orthodontic tooth movement in osteoporosis under mechanical stretch stress DOI
Xinyu Liu,

Jiang Huang,

Huimin Wang

et al.

Research Square (Research Square), Journal Year: 2024, Volume and Issue: unknown

Published: Sept. 25, 2024

Abstract Curculigoside (CCG), a natural glycoside compound extracted from the traditional Chinese medicinal herb Curculigo orchioides, is known for its osteogenic differentiation-promoting effects. In this study, we investigated anti-osteoporotic effects of CCG under mechanical stress. Establishing an osteoporotic orthodontic force cell model, found that treatment could promote differentiation in MC3T3-E1 cells and enhance expression factors such as COL1, BMP2, ALP, RUNX2. Furthermore, applied to rats undergoing tooth movement (OTM) observe in vivo activity. Through detection serum ALP levels, X-ray femur, Micro-CT maxillary, alleviate reduction bone density caused by osteoporosis (OP) decrease loss alveolar mass during OTM. summary, can stress, it beneficial formation OTM OP.

Language: Английский

Citations

0
Impact of Hypoxia on Alveolar Bone Dynamics and Remodeling DOI Creative Commons
Sangeetha Narasimhan, Sausan Al Kawas, Shishir Shetty

et al.

Heliyon, Journal Year: 2024, Volume and Issue: 10(23), P. e40868 - e40868

Published: Dec. 1, 2024

Oxygen is a fundamental requirement for cellular metabolism. Hypoxia state of oxygen deprivation the tissues. Cells develop numerous adaptive mechanisms to survive hypoxic insult. Alveolar bone unique structure that encases and protects tooth. Literature reports hypoxia, in all forms, impacts alveolar health. The hypoxia-inducible pathway appears play key role mediating changes Embryonic hypoxia plays vital craniofacial skeletal development. Further, has been anticipated repair extraction sockets. cells respond distinctly conditions with both beneficial detrimental effects. Studies have demonstrated enhanced resorption upon stimuli. However, also shown potential therapeutic effects on by triggering an angiogenic response. Additionally, type, duration, mode are critical varied responses main objective this review recapitulate different types tooth supporting apparatus analyze some presumptive underlying hypoxia-induced remodeling.

Language: Английский

Citations

0