Targeted inhibition of ferroptosis in bone marrow mesenchymal stem cells by engineered exosomes alleviates bone loss in smoking-related osteoporosis
Yao Wang,
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Lin Sun,
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Zixu Dong
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et al.
Materials Today Bio,
Journal Year:
2025,
Volume and Issue:
unknown, P. 101501 - 101501
Published: Jan. 1, 2025
Smoking-related
osteoporosis
(SROP)
is
characterized
by
reduced
bone
mass,
primarily
due
to
the
accumulation
of
tobacco-derived
toxins.
This
study
demonstrates
activation
ferroptosis
and
reactive
oxygen
species
(ROS)-related
pathways
in
marrow
mesenchymal
stem
cells
(BMSCs)
SROP
mice.
Here,
we
integrated
genetic
engineering
bone-targeting
peptide
modification
develop
innovative
engineered
exosomes.
Using
techniques,
introduced
α-1,3-fucosyltransferase
6
(Fut6),
a
key
protein
involved
prostate
cancer
metastasis,
identified
exosomes
expressing
Fut6
(F6-exo)
with
capabilities.
Additionally,
modified
these
peptide,
(AspSerSer)6,
synthesize
F6-(DSS)6-exo.
F6-(DSS)6-exo
enabled
targeted
delivery
curcumin,
restoring
osteogenic
differentiation
potential
BMSCs
mitigating
loss
mouse
models.
In
summary,
this
highlights
combination
hydrophobic
diacylglycerol
insertion
as
novel
therapeutic
approach
for
SROP.
Language: Английский
Causal association among smoking, bitter beverage consumption, and risk of osteoporosis: a two-sample mendelian randomization-based study
Yanqian Wu,
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J. Chao,
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Min Bao
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et al.
Hereditas,
Journal Year:
2025,
Volume and Issue:
162(1)
Published: Jan. 24, 2025
Abstract
Objectives
Two-sample
MR
methods
were
employed
to
analyze
the
impact
of
smoking
and
bitter
beverage
consumption
on
risk
osteoporosis
with
pathological
fractures,
in
order
assess
causal
association.
Methods
Publicly
available
genome-wide
association
study
summary
data
analyzed
using
methods.
The
exposures
investigated
(smoking
per
day,
initiation,
lifetime
index)
beverages
(coffee,
tea,
alcoholic
beverages,
non-alcoholic
total
beverages).
outcomes
examined
fractures.
inverse-variance
weighted
(IVW)
method
was
used
as
main
statistical
model.
stability
reliability
results
verified
by
Cochran’s
Q
test,
Egger-intercept
leave-one-out
analysis.
Results
Smoking
day
causally
associated
OR
=
1.417,
95%
CI
1.119–1.794,
P
0.003),
index
had
a
possible
genetic
fractures
(OR
4.187,
1.909–9.184,
<
0.001).
No
found
between
initiation
or
(
>
0.05).
identified
Total
showed
potential
effect
3.687,
1.535–8.858,
0.003
3.040,
1.466–6.304,
0.002,
respectively).
Conclusions
This
raises
based
genetics.
Certain
are
linked
an
increased
risk.
Language: Английский
Associations between smoking and osteoporosis and all-cause mortality in participants from the United States: a cohort study
Xiaoqin Qu,
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Jie-Xian Jiang,
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Qingshan Deng
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et al.
Frontiers in Endocrinology,
Journal Year:
2025,
Volume and Issue:
16
Published: March 24, 2025
Background
Smoking
is
a
global
public
health
concern,
with
approximately
1,245
billion
smokers
worldwide.
It
associated
range
of
complications,
including
cardiovascular
and
respiratory
diseases.
Osteoporosis,
characterized
by
reduced
bone
density
deterioration
tissue,
has
prevalence
18.3%,
higher
rates
in
women
over
the
age
50.
been
recently
osteoporosis,
potentially
due
to
shared
metabolic
disorders
or
personal
habits.
This
study
aimed
investigate
association
between
smoking
osteoporosis
relation
all-cause
mortality
cohort
from
United
States.
Methods
Data
were
sourced
National
Health
Nutrition
Examination
Survey
(NHANES)
database,
which
focuses
on
individuals
aged
20
years
older
2005–2010,
2013–2014,
2017–2018,
where
femoral
neck
testing
was
conducted.
The
participants
categorized
basis
their
self-reported
status
mineral
(BMD)
measurements,
following
World
Organization
criteria
for
osteoporosis.
covariates
included
age,
sex,
race,
alcohol
consumption,
BMI,
blood
glucose
levels,
other
indicators.
Statistical
analysis
ANOVA
chi-square
tests
baseline
characteristics,
Kaplan–Meier
survival
analysis,
multivariate
Cox
regression
assess
hazard
ratios
(HRs)
95%
confidence
intervals
(CIs)
mortality.
We
divided
patients
into
four
different
groups
via
cross-classification
method
whether
they
had
Results
19,400
participants,
significant
differences
characteristics
across
4
(S-/OP+:
nonsmokers
osteoporosis;
S+/OP-:
without
S-/OP-:
S+/OP+:
osteoporosis).
overall
average
53.1
years,
accounted
49.6%
total
population.
rate
all
factors
population
13.1%,
highest
S+/OP+
rate.
Participants
both
history
146%
increase
(HR:
2.46,
CI:
2.12–2.87)
even
after
adjusting
confounding
factors.
relative
excess
risk
interaction
(RERI)
suggested
lack
statistical
significance,
whereas
attributable
proportion
(AP)
indicated
synergistic
effect
Conclusions
highlights
importance
managing
preventing
reduce
findings
provide
preliminary
evidence
risk,
emphasizing
need
proactive
strategies
cessation
close
monitoring
conditions.
Language: Английский
Smoking, Genetic Susceptibility and Early Menopause: Unveiling Biological Mechanisms and Potential Therapy Targets
Yuhang Liang,
No information about this author
Jie Ou,
No information about this author
Jing Fu
No information about this author
et al.
BJOG An International Journal of Obstetrics & Gynaecology,
Journal Year:
2024,
Volume and Issue:
unknown
Published: Dec. 27, 2024
ABSTRACT
Objective
To
explore
the
association
between
smoking,
genetic
susceptibility
and
early
menopause
(EM)
clarify
potential
mechanisms
underlying
this
relationship.
Design
An
observational
Transcriptome‐wide
analysis
(TWAS)
study.
Setting
UK
Biobank
public
summary
statistics.
Population
139
869
women
with
full
baseline
data,
no
gynaecological
surgery
history.
Methods
Adjusted
modified
Poisson
regression
models
were
developed
to
determine
smoking
risk
effects
on
EM.
TWAS
was
used
identify
gene
expression
EM,
Mendelian
randomisation
(MR)
infer
causality.
Enrichment
explored
regulatory
networks
of
transcription
factors,
microRNAs
therapeutic
targets.
Small
molecule
drugs
predicted
using
drug‐gene
interaction
analysis.
Main
Outcome
Measures
EM
prevalence
common
patterns.
Results
Women
over
30
pack‐years
had
about
1.5
times
higher
risk,
RRs
1.39
(95%CI,
1.23–1.56),
1.45
(1.33–1.59)
(1.36–1.55)
in
low,
intermediate
high
groups.
identified
hub
genes
such
as
IMMP2L,
BMPR2
HMGN1.
MR
confirmed
daily
cigarette
consumption
a
causal
factor
menopause.
Several
targets
(e.g.,
SP600125,
INCB18424
ruxolitinib)
identified.
Conclusions
Smoking
reduction
significantly
lowered
Hub
provided
new
avenues
for
mitigating
harmful
smoking.
Language: Английский