Telomere-to-Telomere Genome Assembly UncoversWolbachia-Driven Sex-Specific Demography and Challenges Fisher’s Principle in a Sawfly DOI Creative Commons
Mingpeng Zhang, R. Grace Zhai, Gengyun Niu

et al.

bioRxiv (Cold Spring Harbor Laboratory), Journal Year: 2024, Volume and Issue: unknown

Published: Dec. 17, 2024

Abstract Wolbachia , a widespread endosymbiotic bacterium, can reshape the evolutionary fates of its insect hosts by distorting reproduction and altering population dynamics. Despite extensive laboratory research, long-term effects on host evolution in nature remain poorly understood, particularly regarding genetic mechanisms underlying changes sex determination reproduction. Here, we report first telomere-to-telomere (T2T) genome assembly sawfly Analcellicampa danfengensis complete it symbiotic . Comparative genomics six closely related species revealed that -infected populations experience marked sex-specific demography. While uninfected maintain balanced features between males females, infected show persistent reduction male effective size alongside stable or even growing female population, ultimately driving toward extinction. Genomic scans identified positively selected genes associated with reproductive functions, sensory perception, neural development, longevity, suggesting manipulates critical biological pathways to promote transmission. These findings provide direct genomic evidence acts as powerful force, reshaping genomes way disrupts Fisher’s principle, female-biased demography extinction at timescales. This work provides deeper insights into host– endosymbiont coevolution has important implications for theory pest management strategies.

Language: Английский

Telomere-to-Telomere Genome Assembly UncoversWolbachia-Driven Sex-Specific Demography and Challenges Fisher’s Principle in a Sawfly DOI Creative Commons
Mingpeng Zhang, R. Grace Zhai, Gengyun Niu

et al.

bioRxiv (Cold Spring Harbor Laboratory), Journal Year: 2024, Volume and Issue: unknown

Published: Dec. 17, 2024

Abstract Wolbachia , a widespread endosymbiotic bacterium, can reshape the evolutionary fates of its insect hosts by distorting reproduction and altering population dynamics. Despite extensive laboratory research, long-term effects on host evolution in nature remain poorly understood, particularly regarding genetic mechanisms underlying changes sex determination reproduction. Here, we report first telomere-to-telomere (T2T) genome assembly sawfly Analcellicampa danfengensis complete it symbiotic . Comparative genomics six closely related species revealed that -infected populations experience marked sex-specific demography. While uninfected maintain balanced features between males females, infected show persistent reduction male effective size alongside stable or even growing female population, ultimately driving toward extinction. Genomic scans identified positively selected genes associated with reproductive functions, sensory perception, neural development, longevity, suggesting manipulates critical biological pathways to promote transmission. These findings provide direct genomic evidence acts as powerful force, reshaping genomes way disrupts Fisher’s principle, female-biased demography extinction at timescales. This work provides deeper insights into host– endosymbiont coevolution has important implications for theory pest management strategies.

Language: Английский

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