Macrophage states: there's a method in the madness DOI Creative Commons
Gajanan D. Katkar, Pradipta Ghosh

Trends in Immunology, Journal Year: 2023, Volume and Issue: 44(12), P. 954 - 964

Published: Nov. 7, 2023

Single-cell approaches have shone a spotlight on discrete context-specific tissue macrophage states, deconstructed to their most minute details. Machine-learning (ML) recently challenged that dogma by revealing context-agnostic continuum of states shared across tissues. Both agree 'brake' and 'accelerator' subpopulations must be balanced achieve homeostasis. also highlight the importance ensemble fluidity as switch between wide ranges accelerator brake phenotypes mount optimal wholistic response any threat. A full comprehension rules govern these is promising avenue because it can help formulate precise re-education therapeutic strategies might selectively boost or suppress disease-associated various

Language: Английский

Macrophage states: there's a method in the madness DOI Creative Commons
Gajanan D. Katkar, Pradipta Ghosh

Trends in Immunology, Journal Year: 2023, Volume and Issue: 44(12), P. 954 - 964

Published: Nov. 7, 2023

Single-cell approaches have shone a spotlight on discrete context-specific tissue macrophage states, deconstructed to their most minute details. Machine-learning (ML) recently challenged that dogma by revealing context-agnostic continuum of states shared across tissues. Both agree 'brake' and 'accelerator' subpopulations must be balanced achieve homeostasis. also highlight the importance ensemble fluidity as switch between wide ranges accelerator brake phenotypes mount optimal wholistic response any threat. A full comprehension rules govern these is promising avenue because it can help formulate precise re-education therapeutic strategies might selectively boost or suppress disease-associated various

Language: Английский

Citations

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