Extracellular Cold-Inducible RNA-Binding Protein: Progress from Discovery to Present DOI Open Access
Monowar Aziz,

I. H. Chaudry,

Ping Wang

et al.

International Journal of Molecular Sciences, Journal Year: 2025, Volume and Issue: 26(8), P. 3524 - 3524

Published: April 9, 2025

Extracellular cold-inducible RNA-binding protein (eCIRP) is a critical damage-associated molecular pattern (DAMP) that drives inflammation and tissue injury in hemorrhagic septic shock, has emerged as promising therapeutic target. Since then, extensive research using preclinical models of diseases patient materials explored eCIRP's role driving inflammatory responses its potential biomarker. The main objective this comprehensive review to provide detailed overview eCIRP, covering discovery, disease pathophysiology, mechanisms release action, biomarker, strategies targeting eCIRP ischemic diseases. We examine the molecular, cellular, immunological through which contributes progression, explore both well-established emerging areas research. Furthermore, we discuss across broad spectrum conditions, including ischemia-reperfusion injury, neurodegenerative diseases, radiation injury.

Language: Английский

Extracellular Cold-Inducible RNA-Binding Protein: Progress from Discovery to Present DOI Open Access
Monowar Aziz,

I. H. Chaudry,

Ping Wang

et al.

International Journal of Molecular Sciences, Journal Year: 2025, Volume and Issue: 26(8), P. 3524 - 3524

Published: April 9, 2025

Extracellular cold-inducible RNA-binding protein (eCIRP) is a critical damage-associated molecular pattern (DAMP) that drives inflammation and tissue injury in hemorrhagic septic shock, has emerged as promising therapeutic target. Since then, extensive research using preclinical models of diseases patient materials explored eCIRP's role driving inflammatory responses its potential biomarker. The main objective this comprehensive review to provide detailed overview eCIRP, covering discovery, disease pathophysiology, mechanisms release action, biomarker, strategies targeting eCIRP ischemic diseases. We examine the molecular, cellular, immunological through which contributes progression, explore both well-established emerging areas research. Furthermore, we discuss across broad spectrum conditions, including ischemia-reperfusion injury, neurodegenerative diseases, radiation injury.

Language: Английский

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