Mechanisms and therapeutic potential of epithelial-immune crosstalk in airway inflammation DOI
Ying Chen, Yujuan Yang, Huifang Liu

et al.

Expert Review of Clinical Immunology, Journal Year: 2025, Volume and Issue: unknown

Published: June 1, 2025

Chronic airway inflammatory diseases mainly comprise chronic rhinosinusitis (CRS), allergic rhinitis (AR), asthma, cystic fibrosis (CF), and obstructive pulmonary disease (COPD). Epithelial cells fulfill a protective role as barrier; however, when stimulated, these also release variety of cytokines that attract activate immune cells, including macrophages, neutrophils, T-lymphocytes. Excessive activation aggregation disrupts the balance cellular microenvironment, leads to impaired defense mucosa, which can further exacerbate an response. In this article, we discuss key pathways involved in epithelial-immune cell interactions, detail discoveries emerging field single-cell sequencing summarize monoclonal antibody-targeted therapies. A comprehensive search was conducted using terms 'epithelial cell,' 'immune,' 'interaction,' 'cytokines,' 'asthma,' 'chronic sinusitis,' 'allergic rhinitis,' 'monoclonal antibodies,' 'single-cell sequencing' by querying Google Scholar PubMed. The intricate pathophysiology inflammation remains be fully elucidated. Emerging technologies, such sequencing, have led more characterization mechanisms underlying diseases, points way precision medicine future.

Language: Английский

Mechanisms and therapeutic potential of epithelial-immune crosstalk in airway inflammation DOI
Ying Chen, Yujuan Yang, Huifang Liu

et al.

Expert Review of Clinical Immunology, Journal Year: 2025, Volume and Issue: unknown

Published: June 1, 2025

Chronic airway inflammatory diseases mainly comprise chronic rhinosinusitis (CRS), allergic rhinitis (AR), asthma, cystic fibrosis (CF), and obstructive pulmonary disease (COPD). Epithelial cells fulfill a protective role as barrier; however, when stimulated, these also release variety of cytokines that attract activate immune cells, including macrophages, neutrophils, T-lymphocytes. Excessive activation aggregation disrupts the balance cellular microenvironment, leads to impaired defense mucosa, which can further exacerbate an response. In this article, we discuss key pathways involved in epithelial-immune cell interactions, detail discoveries emerging field single-cell sequencing summarize monoclonal antibody-targeted therapies. A comprehensive search was conducted using terms 'epithelial cell,' 'immune,' 'interaction,' 'cytokines,' 'asthma,' 'chronic sinusitis,' 'allergic rhinitis,' 'monoclonal antibodies,' 'single-cell sequencing' by querying Google Scholar PubMed. The intricate pathophysiology inflammation remains be fully elucidated. Emerging technologies, such sequencing, have led more characterization mechanisms underlying diseases, points way precision medicine future.

Language: Английский

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