Effects of treatment of non-alcoholic fatty liver disease on heart failure with preserved ejection fraction DOI Creative Commons

Zifeng Yang,

Ruifeng Tian, Xiao‐Jing Zhang

et al.

Frontiers in Cardiovascular Medicine, Journal Year: 2023, Volume and Issue: 9

Published: Jan. 12, 2023

In the past few decades, non-alcoholic fatty liver disease (NAFLD) and heart failure with preserved ejection fraction (HFpEF) have become most common chronic main form of (HF), respectively. NAFLD is closely associated HFpEF by sharing risk factors and/or boosting systemic inflammation, releasing other secretory factors, having an expansion epicardial adipose tissue (EAT). Therefore, treatments may also affect development prognosis HFpEF. However, no specific drugs for been approved Food Drug Administration (FDA) some non-specific are applied in clinic. Currently, can be divided into non-pharmacological pharmacological treatments. Non-pharmacological mainly include dietary intervention, weight loss exercise, caloric restriction, bariatric surgery. Pharmacological administering statins, thiazolidinediones, glucagon-like peptide-1 receptor agonists, sodium-glucose cotransporter 2 inhibitors, metformin. This review will focus on analyzing how these

Language: Английский

Streptozotocin-Induced Type 1 and 2 Diabetes Mellitus Mouse Models Show Different Functional, Cellular and Molecular Patterns of Diabetic Cardiomyopathy DOI Open Access
Fabiola Marino, Nadia Salerno, Mariangela Scalise

et al.

International Journal of Molecular Sciences, Journal Year: 2023, Volume and Issue: 24(2), P. 1132 - 1132

Published: Jan. 6, 2023

The main cause of morbidity and mortality in diabetes mellitus (DM) is cardiovascular complications. Diabetic cardiomyopathy (DCM) remains incompletely understood. Animal models have been crucial exploring DCM pathophysiology while identifying potential therapeutic targets. Streptozotocin (STZ) has widely used to produce experimental both type 1 2 DM (T1DM T2DM). Here, we compared these two for their effects on cardiac structure, function transcriptome. Different doses STZ diet chows were generate T1DM T2DM C57BL/6J mice. Normal euglycemic nonobese sex- age-matched mice served as controls (CTRL). Immunohistochemistry, RT-PCR RNA-seq employed compare hearts from the three animal groups. STZ-induced affected left ventricular myocardial performance differently. displayed exaggerated apoptotic cardiomyocyte (CM) death reactive hypertrophy fibrosis, along with increased oxidative stress, CM DNA damage senescence, when whole transcriptome In conclusion, mouse showed significant differences remodeling, These could be key relevance choosing an model study specific features DCM.

Language: Английский

Citations

50
High triglyceride-glucose (TyG) index is associated with poor prognosis of heart failure with preserved ejection fraction DOI Creative Commons
Qing Zhou, Jie Yang,

Hongyi Tang

et al.

Cardiovascular Diabetology, Journal Year: 2023, Volume and Issue: 22(1)

Published: Sept. 29, 2023

The impact of insulin resistance on the prognosis heart failure with preserved ejection fraction (HFpEF) remains unknown. This study aimed to investigate association between triglyceride-glucose (TyG) index, an easily calculated marker resistance, and long-term HFpEF.A total 823 patients HFpEF were enrolled in study. TyG index was determined using formula ln(fasting triglycerides [mg/dL] × fasting glucose [mg/dL]/2). primary endpoint all-cause death. secondary endpoints cardiovascular (CV) death (HF) rehospitalization. Restricted cubic spline, multivariate Cox proportional hazard models, competing risk models used for analyses.During a median follow-up period 3.16 years, 147 (17.8%) deaths, 139 (16.8%) CV 222 (27.0%) HF rehospitalizations occurred. spline analysis revealed J-shaped mortality rehospitalization rates. In compared those lowest tertile, highest tertile exhibited greatest susceptibility (HR 1.53, 95% CI 1.19-1.98) 1.52, 1.19-1.96). model, significant observed 1.31, CI, 1.07-1.61).A high is associated increased HFpEF. may serve as promising prognostic

Language: Английский

Citations

45
Amyloid-β and heart failure in Alzheimer’s disease: the new vistas DOI Creative Commons
Hayder M. Al‐kuraishy, Ghassan M. Sulaiman, Hamdoon A. Mohammed

et al.

Frontiers in Medicine, Journal Year: 2025, Volume and Issue: 12

Published: Feb. 4, 2025

Alzheimer’s disease (AD) is the most common cause of dementia and represents 75% all types. AD neuropathology due to progressive deposition extracellular amyloid-beta (A β ) peptide intracellular hyperphosphorylated tau protein. The accumulated Aβ forms amyloid plaques, while protein neurofibrillary tangles (NFTs). Both plaques NFTs are hallmarks neuropathology. fundamental mechanism involved in pathogenesis still elusive, although more conceivable theory. Aβ-induced neurodegeneration associated neuroinflammation, oxidative stress, endoplasmic reticulum stress (ER), mitochondrial dysfunction contribute development cognitive impairment dementia. Of note, not only originated from brain but also produced peripherally and, via blood–brain barrier (BBB), can accumulate result AD. It has been shown that cardiometabolic conditions such as obesity, type 2 diabetes (T2D), heart failure (HF) regarded possible risk factors for other types dementia, vascular HF-induced chronic cerebral hypoperfusion, inflammation induce progression Interestingly, a systemic causes which turn affects peripheral organs, including heart. through deranged BBB be transported into circulation heart, leading HF. These findings suggest close relationship between However, exact AD-induced HF fully elucidated. Therefore, this review aims discuss link regarding potential role

Language: Английский

Citations

4
Semaglutide in obesity-related heart failure with preserved ejection fraction and type 2 diabetes across baseline HbA1c levels (STEP-HFpEF DM): a prespecified analysis of heart failure and metabolic outcomes from a randomised, placebo-controlled trial DOI
Melanie J. Davies, Peter van der Meer, Subodh Verma

et al.

The Lancet Diabetes & Endocrinology, Journal Year: 2025, Volume and Issue: unknown

Published: Jan. 1, 2025

Language: Английский

Citations

2
Epicardial adipose tissue density is a better predictor of cardiometabolic risk in HFpEF patients: a prospective cohort study DOI Creative Commons

Jie Liu,

Qi Yu, Ziyang Li

et al.

Cardiovascular Diabetology, Journal Year: 2023, Volume and Issue: 22(1)

Published: March 4, 2023

Abstract Background Epicardial adipose tissue (EAT) accumulation is associated with multiple cardiometabolic risk factors and prognosis of heart failure preserved ejection fraction (HFpEF). The correlation between EAT density the effect on clinical outcome in HFpEF remain unclear. We evaluated relationship factors, also prognostic value patients HFpEF. Methods included 154 who underwent noncontrast cardiac computed tomography (CT) all received follow-up. volume were quantified semi-automatically. associations metabolic syndrome impact analyzed. Results Lower was adverse changes factors. Each 1 HU increase fat density, BMI 0.14 kg/m 2 lower (95% CI 0.08–0.21), waist circumference 0.34 cm 0.12–0.55), non-HDL-cholesterol 0.02 mmol/L 0–0.04), triglyceride 0.03 0.01–0.04), fasting plasma glucose 0.05 0.02–0.08), TyG index 0.02–0.04), Log (TG/HDL-C) 0.02–0.05), METS-IR 0.36 0.23–0.49), MetS Z-score 0.04 0.02–0.06), (CACS + 1) 0.09 0.02–0.15). After adjusting for volume, non-HDL-cholesterol, triglyceride, glucose, insulin resistance indexes, Z-score, CACS remained significant. area under curve (AUC) presence severity greater than (AUC: 0.731 vs 0.694, 0.735 0.662, respectively). Over a median follow-up 16 months, cumulative incidence readmission composite endpoint increased level (both p < 0.05). Conclusions an independent factor might have better predictive it

Language: Английский

Citations

35
miR-181c targets Parkin and SMAD7 in human cardiac fibroblasts: Validation of differential microRNA expression in patients with diabetes and heart failure with preserved ejection fraction DOI
Stanislovas S. Jankauskas, Pasquale Mone, Roberta Avvisato

et al.

Mechanisms of Ageing and Development, Journal Year: 2023, Volume and Issue: 212, P. 111818 - 111818

Published: April 27, 2023

Language: Английский

Citations

30
New Mechanisms to Prevent Heart Failure with Preserved Ejection Fraction Using Glucagon-like Peptide-1 Receptor Agonism (GLP-1 RA) in Metabolic Syndrome and in Type 2 Diabetes: A Review DOI Open Access
Jorge Jalil, Luigi Gabrielli, María Paz Ocaranza

et al.

International Journal of Molecular Sciences, Journal Year: 2024, Volume and Issue: 25(8), P. 4407 - 4407

Published: April 17, 2024

This review examines the impact of obesity on pathophysiology heart failure with preserved ejection fraction (HFpEF) and focuses novel mechanisms for HFpEF prevention using a glucagon-like peptide-1 receptor agonism (GLP-1 RA). Obesity can lead to through various mechanisms, including low-grade systemic inflammation, adipocyte dysfunction, accumulation visceral adipose tissue, increased pericardial/epicardial tissue (contributing an increase in myocardial fat content interstitial fibrosis). Glucagon-like peptide 1 (GLP-1) is incretin hormone that released from enteroendocrine L-cells gut. GLP-1 reduces blood glucose levels by stimulating insulin synthesis, suppressing islet α-cell function, promoting proliferation differentiation β-cells. regulates gastric emptying appetite, RA currently indicated treating type 2 diabetes (T2D), obesity, metabolic syndrome (MS). Recent evidence indicates may play significant role preventing patients MS, or obese T2D. effect be due activating cardioprotective (the endogenous counter-regulatory renin angiotensin system AMPK/mTOR pathway) inhibiting deleterious remodeling PKA/RhoA/ROCK pathway, aldosterone levels, microinflammation). However, there still need further research validate these humans.

Language: Английский

Citations

10
Natural products targeting AMPK signaling pathway therapy, diabetes mellitus and its complications DOI Creative Commons
Min Li,

Lu Ding,

L. Cao

et al.

Frontiers in Pharmacology, Journal Year: 2025, Volume and Issue: 16

Published: Feb. 3, 2025

Diabetes mellitus (DM) ranks among the most prevalent chronic metabolic diseases, characterized primarily by a persistent elevation in blood glucose levels. This condition typically stems from either insufficient insulin secretion or functional defect itself. Clinically, diabetes is classified into type 1 (T1DM) and 2 (T2DM), with T2DM comprising nearly 90% of all diagnosed cases. Notably, global incidence has surged dramatically over recent decades. The adenylate-activated protein kinase (AMPK) signaling pathway crucial regulating cellular energy metabolism, marking it as significant therapeutic target for related complications. Natural products, their diverse origins, multifaceted bioactivities, relative safety, hold considerable promise modulating AMPK pathway. review article explores advances research on natural products that pathway, aiming to inform development innovative antidiabetic therapies.

Language: Английский

Citations

1
Underpinnings of Heart Failure With Preserved Ejection Fraction in Women - From Prevention to Improving Function. A Co-publication With the American Journal of Preventive Cardiology and the Journal of Cardiac Failure DOI

Archanna Radakrishnan,

Shashank Agrawal, Neha Singh

et al.

Journal of Cardiac Failure, Journal Year: 2025, Volume and Issue: unknown

Published: Feb. 1, 2025

Language: Английский

Citations

1
FBXL4 protects against HFpEF through Drp1-Mediated regulation of mitochondrial dynamics and the downstream SERCA2a DOI Creative Commons
Miyesaier Abudureyimu,

Xuanming Luo,

Lingling Jiang

et al.

Redox Biology, Journal Year: 2024, Volume and Issue: 70, P. 103081 - 103081

Published: Feb. 9, 2024

Heart failure with preserved ejection fraction (HFpEF) is a devastating health issue although limited knowledge available for its pathogenesis and therapeutics. Given the perceived involvement of mitochondrial dysfunction in HFpEF, this study was designed to examine role dynamics etiology HFpEF.

Language: Английский

Citations

7