International Journal of Molecular Sciences, Journal Year: 2024, Volume and Issue: 25(15), P. 8012 - 8012
Published: July 23, 2024
Coronaviruses constitute a global threat to human and animal health. It is essential investigate the long-distance RNA-RNA interactions that approximate remote regulatory elements in strategies, including genome circularization, discontinuous transcription, transcriptional enhancers, aimed at rapid replication of their large genomes, pathogenicity, immune evasion. Based on primary sequences modeled two experimentally defined coronaviral we detected via an silico secondary structural analysis potential enhancers various coronaviruses, from phylogenetically ancient avian infectious bronchitis virus (IBV) recently emerged SARS-CoV-2. These possess core duplex-forming region could transition between closed open states, as molecular switches directed by viral or host factors. The duplex state would pair with modulate expression downstream crucial genes involved Consistently, variations predicted IBV enhancer its distant targets coincide cases attenuation, possibly driven decreased reading frame (ORF)3a evasion protein expression. If validated experimentally, annotated inform prediction tools antiviral interventions.
Language: Английский