bioRxiv (Cold Spring Harbor Laboratory), Journal Year: 2024, Volume and Issue: unknown
Published: Sept. 8, 2024
Abstract Background Mosquitoes in the Anopheles ( An. ) gambiae species complex are major vectors of Plasmodium falciparum malaria. One reason for this is high anthropophily constituent coluzzii , sensu stricto, and arabiensis . In contrast, their sister quadriannulatus highly zoophilic. mosquitoes largely rely on chemical cues host-seeking, which primarily detected by four chemosensory gene families: olfactory receptors Ors ), ionotropic Irs gustatory Grs odorant binding proteins Obps ). Genes from these families that have been implicated host adaptation show evidence positive selection other insect species, including mosquitoes. As such, we analyzed molecular evolutionary patterns within complex, with a particular interest identifying anthropophilic species. Results We identified sixteen potential using McDonald-Kreitman test, putative sugar two unknown ligands relatively expressed organs either or addition, twelve purifying may experienced selective sweep DH three carbon dioxide receptor Gr24 also both coastal melas (West Africa) merus (East Africa). Conclusions Our results, together transcriptomic data, identify as possible candidates involvement evolution vertebrate preference occurred farauti complex. They point to playing role recent some vast majority functions much still about more complete interpretation our data necessitates further characterization genes.
Language: Английский
