Novel chikungunya and dengue vaccines: travel medicine applications

Journal of Travel Medicine, Journal Year: 2024, Volume and Issue: 31(4)

Published: April 18, 2024

Recent epidemics of dengue and chikungunya have highlighted the urgent need for vaccines to reduce risk infection in travellers. Given challenges with tracking outbreaks real-time widespread resurgence dengue, broader indications use new should be considered.

Language: Английский

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The Deadly Details: How Clear and Complete Are Publicly Available Sources of Human Rabies Information?

Tropical Medicine and Infectious Disease, Journal Year: 2025, Volume and Issue: 10(1), P. 16 - 16

Published: Jan. 7, 2025

Human rabies is preventable but almost always fatal once symptoms appear, causing 59,000 global deaths each year. Limited awareness and inconsistent access to post-exposure prophylaxis hinder prevention efforts. To identify gaps opportunities for improvement in online information, we assessed the readability, understandability, actionability, completeness of public resources from government health agencies Australia similar countries, with aim identifying improvement. We identified materials via Google agency websites, assessing readability using Simple Measure Gobbledygook (SMOG) index understandability actionability Patient Education Materials Tool Print (PEMAT-P). Completeness was a framework focused on general vaccine-specific information. An analysis 22 found median grade 13 (range: 10-15), mean 66% 60%; both below recommended thresholds. Mean 79% information 36% Visual aids were under-utilised, critical often lacking. These findings highlight significant barriers public, most requiring high literacy level lacking adequate actionability. Improving adding visual aids, enhancing vaccine-related content could improve accessibility support wider

Language: Английский

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Seroprevalence of dengue, Japanese encephalitis and Zika among long-term expatriates in Thailand

Journal of Travel Medicine, Journal Year: 2024, Volume and Issue: 31(2)

Published: Feb. 9, 2024

Abstract Background Travel to Southeast Asia increases the likelihood of acquiring mosquito-borne Flavivirus infections such as dengue (DENV), Japanese encephalitis (JEV) and Zika viruses (ZIKV). Expatriates are long-term travellers who have a higher risk illness at their destination country. The purpose this study was evaluate seroprevalence DENV, JEV ZIKV determinants contributing seropositivity among expatriates living in Thailand. Methods A cross-sectional performed from December 2017 February 2020. non-Flavivirus endemic countries were recruited. 5 mL blood collected for DENV 1–4, antibody testing by plaque reduction neutralization test (PRNT50). Individuals with vaccination histories or diagnoses dengue, encephalitis, yellow fever tick-borne excluded. Results Among 254 participants, most participants (83.1%) male, mean age 65 years median duration stay Thailand 6 years. Seroprevalence rate any Flavivirus, non-specific DENV1–4, 34.3, 30.7, 20.5, 18.1, 18.9, 10.6, 4.7 2.8%, respectively. presence neutralizing antibodies against DENV1–4 positively correlates associated urban areas (aOR 2.75, 95% CI 1.36–5.57). unlikely detectable anti-JEV regardless time spent JEV-endemic area. No factors identified that significantly seropositivity. Only 48.4% received pre-travel counselling services, while only 18.9% visited travel medicine specialist. Conclusions high proportion (34.3%) seropositive flavivirus, mainly (30.7%). To minimize risk, practitioners should provide adequate health information on flavivirus infection offer advice mosquito bite prevention strategies. Dengue vaccine might be considered high-risk expatriate.

Language: Английский

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Interventions to increase vaccination against COVID-19, influenza and pertussis during pregnancy: a systematic review and meta-analysis

Journal of Travel Medicine, Journal Year: 2023, Volume and Issue: 30(8)

Published: Nov. 2, 2023

Abstract Background Pregnant women and their babies face significant risks from three vaccine-preventable diseases: COVID-19, influenza pertussis. However, despite these vaccines’ proven safety effectiveness, uptake during pregnancy remains low. Methods We conducted a systematic review (PROSPERO CRD42023399488; January 2012–December 2022 following PRISMA guidelines) of interventions to increase COVID-19/influenza/pertussis vaccination in pregnancy. searched nine databases, including grey literature. Two independent investigators extracted data; discrepancies were resolved by consensus. Meta-analyses using random-effects models estimate pooled effect sizes. Heterogeneity was assessed the I2 statistics. Results From 2681 articles, we identified 39 relevant studies (n = 168 262 participants) across countries. Fifteen (39%) randomized controlled trials (RCTs); remainder observational cohort, quality-improvement or cross-sectional studies. The quality 18% (7/39) strong. Pooled results vaccine (18 estimates 12 RCTs) showed effective but had small (risk ratio 1.07, 95% CI 1.03, 1.13). pertussis (10 six no clear benefit 0.98, 0.94, 1.03). There RCTs for COVID-19. Interventions addressed ‘three Ps’: patient-, provider- policy-level strategies. At patient level, recommendations healthcare professionals backed text reminders/written information strongly associated with increased uptake, especially tailored face-to-face interventions, which women’s concerns, dispelled myths highlighted benefits. Provider-level included educating about effectiveness reminders offer vaccinations routinely. Policy-level financial incentives, mandatory data fields electronic health records ensuring easy availability vaccinations. Conclusions on increasing vaccination. Training providers promote is crucial could be enhanced utilizing mobile technologies.

Language: Английский

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Rabies exposure in international travellers: Experience from a single travel clinic in Paris, France, 2018-2022

Travel Medicine and Infectious Disease, Journal Year: 2025, Volume and Issue: unknown, P. 102821 - 102821

Published: Feb. 1, 2025

Rabies is a vaccine-preventable zoonotic disease which causes thousands of deaths every year, mainly in Asia and Africa, dogs are the main source human cases. Although rabies rare international travellers, exposure relatively frequent number travellers seeking post-exposure treatment may rise as travel continues to increase. We aimed better understand characteristics exposed abroad, order deliver targeted advice vaccination during pre-travel clinics. During 2018-2022, we studied all returning who attended single clinic Paris, France, for animal exposures abroad requiring prophylaxis (n=2,916). study period, 2,916 were included, 59.7% occurred Southeast (mainly Thailand Indonesia) North-Africa. Dogs predominantly responsible exposures, but animals involved varied significantly according region visited age traveller. Monkey more frequently reported Asia, cat North Africa among children. Exposures unprovoked 22.9% cases, 91% had not received anti-rabies vaccines before travelling. Travellers endemic countries should benefit from information based on visited, they likely encounter, travellers. Critically, be counselled importance avoiding contact with animals, long-lasting vaccination, need adequate prophylaxis.

Language: Английский

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Do Statins Affect Viral Infections Encountered by International Travelers?

Tropical Medicine and Infectious Disease, Journal Year: 2025, Volume and Issue: 10(3), P. 73 - 73

Published: March 11, 2025

Statins are among the most frequently prescribed medications. In addition to their well-established effectiveness in lowering total cholesterol, LDL, and triglycerides, statins have been described immunomodulatory anti-inflammatory properties associated with improved endothelial functions. Given common use of statins, we sought evaluate effect on some viral infections encountered by residents tropical areas or international travelers. A literature search was performed PubMED/MEDLINE focusing keywords that included viruses interest, including SARS-CoV-2, influenza, yellow fever, dengue, Zika, tick-borne encephalitis, hemorrhagic fever viruses, hepatitis A, norovirus, B, C, measles, herpesviruses; findings were synthesized for each virus into a summary. The effects vary depending specific virus. While studies indicate potential benefits chronic HBV HCV infections, evidence regarding SARS-CoV-2 influenza remains inconclusive due mixed from observational randomized controlled trials. role other is largely unexplored, preclinical data available only few viruses. conflicting evidence, further prospective trials warranted elucidate statins’ particularly modulating inflammation, dysfunction, immune responses. Future research should aim define optimal patient populations, target statin types, treatment durations may confer infections.

Language: Английский

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Polish travellers on the move: a study of knowledge of travel health and associated practices among Polish travellers abroad

Travel Medicine and Infectious Disease, Journal Year: 2025, Volume and Issue: unknown, P. 102842 - 102842

Published: March 1, 2025

Post-pandemic travel has surged, with 1.3 billion journeys recorded worldwide in 2023, reflecting a growing interest tropical destinations despite the associated health risks. Access to information improved, yet adherence preventive measures remains limited due misinformation, insufficient pre-travel consultations, and concerns about malaria prophylaxis. Based on data from three-year survey, this study examines attitudes of Polish travellers vaccinations, prophylaxis, COVID-19-related measures. Surveys conducted during festivals 2021 2023 targeted adult participants. A questionnaire designed by experts medicine addressed demographics, behaviours, health-related practices. Statistical analyses, including chi-squared tests logistic regression, explored impact demographic factors using Python for analysis. Among 644 participants (mean age 32; 48% male), 49.5% reported vaccination 281 intended use chemoprophylaxis. Gender significantly influenced status Africa. The most cited prevention methods were repellents mosquito nets. Illnesses 317 participants, travellers' diarrhoea (185 cases) common, particularly Turkey, Egypt, India. Forty-eight individuals required medical consultations. Education counselling enhance measures, many fail follow recommendations. Malaria common travel-imported disease EU/EEA, 4,856 cases 2021. Capability, Opportunity, Motivation Behavior (COM-B) model highlights importance addressing these improve compliance behaviours.

Language: Английский

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Landscape analysis of invasive non-typhoidal salmonella (iNTS) disease and iNTS vaccine use case and demand: Report of a WHO expert consultation

Vaccine, Journal Year: 2025, Volume and Issue: 55, P. 127008 - 127008

Published: March 24, 2025

Language: Английский

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Tropenkrankheiten in der Notaufnahme

Notaufnahme up2date, Journal Year: 2025, Volume and Issue: 07(02), P. 185 - 206

Published: April 1, 2025

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Reiseimpfungen – Hinweise und Empfehlungen

Flugmedizin · Tropenmedizin · Reisemedizin - FTR, Journal Year: 2025, Volume and Issue: 32(02), P. 68 - 98

Published: April 1, 2025

Zusammenfassung Der Ständige Ausschuss Reisemedizin (StAR) der Deutschen Gesellschaft für Tropenmedizin, und Globale Gesundheit (DTG) gibt jährlich Empfehlungen zu Reiseimpfungen heraus. Diese Empfehlungen, erstellt von unabhängigen Experten, umfassen länderspezifische risikobasierte Impfstrategien sowie verpflichtende Impfungen internationale Reisen. Sie dienen als Entscheidungshilfe medizinisches Fachpersonal berücksichtigen Erkenntnisse u. a. WHO, des ECDC nationaler Gesundheitsbehörden.

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