IL-17 as a putative hallmark of intense arthralgia and age-related serum immune mediator networks during acute chikungunya fever
Inflammation Research,
Journal Year:
2025,
Volume and Issue:
74(1)
Published: Jan. 11, 2025
Language: Английский
Application of reverse genetics system to Chikungunya virus study
Virology,
Journal Year:
2025,
Volume and Issue:
605, P. 110465 - 110465
Published: Feb. 28, 2025
Language: Английский
Novel peptide inhibitor for the Chikungunya virus nsP2 protease: Identification and Characterization.
Current Research in Microbial Sciences,
Journal Year:
2025,
Volume and Issue:
8, P. 100376 - 100376
Published: Jan. 1, 2025
Chikungunya
virus
(CHIKV)
is
an
emerging
pathogen
affecting
populations
worldwide,
with
rapidly
increasing
infection
rates.
CHIKV,
arbovirus
of
the
alphavirus
genus,
predominantly
found
in
tropical
regions
and
transmitted
by
Aedes
mosquitoes.
Climate
change
has
accelerated
global
spread
these
vectors,
leading
to
outbreaks
non-tropical
regions,
including
parts
Europe.
The
absence
antiviral
therapies
potential
for
co-infections
other
viruses
make
CHIKV
a
significant
public
health
concern.
replication
relies
on
nsP2
cysteine
protease
activity
cleave
its
viral
polyprotein
into
functional
nonstructural
structural
proteins.
Targeting
represents
promising
strategy
therapy
development.
In
this
study,
phage
display
was
used
screen
library
peptides
binders
target
protease.
Biophysical
biochemical
analyses
identified
assessed
their
inhibitory
potential.
Among
six
(named
as
P1-P6),
four
demonstrated
effects
(nsP2pro).
Peptide
P1
exhibited
strongest
effect,
half-maximal
concentration
(IC50)
4.6
±
1.9
µM,
low
cytotoxicity.
secondary
structure
analysis
through
CD
spectroscopy
homology
modelling
revealed
that
adopts
alpha-helical
conformation.
Finally,
molecular
dynamics
simulations
enabled
us
investigate
nsP2pro
active
site
docking
employed
predict
orthosteric
binding
mode
P1,
providing
insights
protein-peptide
interaction.
These
findings
underscore
peptide
lead
compound
further
investigation
context
research.
Language: Английский
Chikungunya Replication and Infection Is Dependent upon and Alters Cellular Hexosylceramide Levels in Vero Cells
Viruses,
Journal Year:
2025,
Volume and Issue:
17(4), P. 509 - 509
Published: March 31, 2025
Chikungunya
virus
(CHIKV),
a
mosquito-borne
alphavirus,
causes
significant
global
morbidity,
including
fever,
rash,
and
persistent
arthralgia.
Utilizing
untargeted
lipidomics,
we
investigated
how
CHIKV
infection
alters
host
cell
lipid
metabolism
in
Vero
cells.
induced
marked
catabolism
of
hexosylceramides,
reducing
their
levels
while
increasing
ceramide
byproducts.
Functional
studies
revealed
reliance
on
fatty
acid
synthesis,
β-oxidation,
glycosphingolipid
biosynthesis.
Notably,
inhibition
uridine
diphosphate
glycosyltransferase
8
(UGT8),
essential
for
galactosylceramide
production,
significantly
impaired
replication
entry
Sensitivity
to
UGT8
was
reproduced
disease-relevant
line,
mouse
hepatocytes
(Hepa1-6).
also
sensitive
evacetrapib,
cholesterol
ester
transfer
protein
(CETP)
inhibitor,
though
the
mechanism
appeared
independent
CETP
itself,
suggesting
an
off-target
effect.
These
findings
highlight
specific
pathways,
particularly
metabolism,
as
critical
further
refine
our
understanding
exploits
networks.
This
study
provides
new
insights
into
biology
suggests
that
targeted
investigation
pathways
may
inform
future
therapeutic
strategies.
Language: Английский
Modeling the impact of vaccine campaigns on the epidemic transmission dynamics of chikungunya virus outbreaks
Nature Medicine,
Journal Year:
2025,
Volume and Issue:
unknown
Published: May 1, 2025
Language: Английский
Emerging Arboviruses in Europe
Deleted Journal,
Journal Year:
2024,
Volume and Issue:
69(4), P. 322 - 337
Published: Dec. 19, 2024
Viruses
transmitted
by
arthropods
(arboviruses)
pose
a
global
public
health
threat.
Sporadic
cases
or
outbreaks
caused
West
Nile
virus,
Crimean–Congo
haemorrhagic
fever
tick-borne
encephalitis
and
phleboviruses
are
often
reported
in
Europe.
Recently,
they
expanded
their
distribution
geographic
areas
where
had
never
been
observed
before,
while
tropical
viruses,
like
Dengue,
Chikungunya,
Zika,
started
to
cause
autochthonous
following
the
return
of
viraemic
travellers
from
endemic
countries.
The
primary
secondary
vectors
these
viruses
established
Europe,
incidence
arboviral
diseases
is
expected
increase
due
several
anthropogenic
and/or
environmental
factors
(mainly
climate
change,
which
affects
survival
amplification
arthropod
vectors).
This
an
update
on
emerging
arboviruses
associated
challenges,
future
perspectives.
Language: Английский
Characterising the 2023 chikungunya outbreak in Paraguay and the potential impact of a vaccine campaign
medRxiv (Cold Spring Harbor Laboratory),
Journal Year:
2024,
Volume and Issue:
unknown
Published: Dec. 5, 2024
Abstract
There
now
exists
a
licensed
chikungunya
vaccine,
however,
it
remains
unclear
if
could
be
deployed
during
outbreaks
to
reduce
the
health
burden.
We
used
an
epidemic
in
Paraguay
as
case
study.
conducted
seroprevalence
study
and
models
reconstruct
transmission
dynamics,
providing
framework
assess
theoretical
impact
of
vaccine
had
been
available.
estimated
33.0%
(95%
CI:
30.1-36.0)
population
became
infected
outbreak,
6.3%
(95%CI:
5.8-6.9)
which
were
detected
by
surveillance
system,
with
mean
infection
fatality
ratio
0.013
%
0.012-0.014).
A
disease-blocking
75%
efficacy
40%
>
12-year-olds
over
three-month
period
would
have
prevented
34,200
30,900-38,000)
cases,
representing
23%
73
66-81)
deaths.
If
also
leads
blocking,
88%
cases
averted.
These
findings
suggest
is
important
new
tool
control
outbreaks.
Language: Английский