Phytomelatonin: A key regulator of redox and phytohormones signaling against biotic/abiotic stresses

Redox Biology, Journal Year: 2023, Volume and Issue: 64, P. 102805 - 102805

Published: June 30, 2023

Plants being sessile in nature, are exposed to unwarranted threats as a result of constantly changing environmental conditions. These adverse factors can have negative impacts on their growth, development, and yield. Hormones key signaling molecules enabling cells respond rapidly different external internal stimuli. In plants, melatonin (MT) plays critical role the integration various signals activation stress-response networks develop defense mechanisms plant resilience. Additionally, tackle stress-induced alteration cellular redox equilibrium by regulating expression hemostasis-related genes proteins. The purpose this article is compile summarize scientific research pertaining MT's effects plants' resilience biotic abiotic stresses. Here, we summarized that MT exerts synergistic effect with other phytohormones, for instance, ethylene, jasmonic acid, salicylic activates defense-related against phytopathogens. Furthermore, interacts secondary messengers like Ca2+, nitric oxide, reactive oxygen species regulate network. This interaction triggers transcription alleviate stress-related responses plants. Hence, synergic diverse hormones demonstrates phytomelatonin's importance influencing multiple contribute harsh factors.

Language: Английский

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Crosstalk between Melatonin and Reactive Oxygen Species in Plant Abiotic Stress Responses: An Update

International Journal of Molecular Sciences, Journal Year: 2022, Volume and Issue: 23(10), P. 5666 - 5666

Published: May 18, 2022

Melatonin acts as a multifunctional molecule that takes part in various physiological processes, especially the protection against abiotic stresses, such salinity, drought, heat, cold, heavy metals, etc. These stresses typically elicit reactive oxygen species (ROS) accumulation. Excessive ROS induce oxidative stress and decrease crop growth productivity. Significant advances melatonin initiate complex antioxidant system modulates homeostasis plants. Numerous evidences further reveal often cooperates with other signaling molecules, ROS, nitric oxide (NO), hydrogen sulfide (H2S). The interaction among melatonin, NO, H2S, orchestrates responses to via networks, thus conferring plant tolerance. In this review, we summarize roles of establishing redox through current progress interactions higher stresses. We highlight vital role respiratory burst oxidase homologs (RBOHs) during these processes. complicated integration occurs between plants is also discussed.

Language: Английский

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Melatonin as a Possible Natural Anti-Viral Compound in Plant Biocontrol

Plants, Journal Year: 2023, Volume and Issue: 12(4), P. 781 - 781

Published: Feb. 9, 2023

Melatonin is a multifunctional and ubiquitous molecule. In animals, melatonin hormone that involved in wide range of physiological activities also an excellent antioxidant. plants, it has been considered master regulator multiple processes as well hormonal homeostasis. Likewise, known for its role protective biomolecule activator tolerance resistance against biotic abiotic stress plants. Since infections by pathogens such bacteria, fungi viruses crops result large economic losses, interest aroused determining whether plays relevant plant defense systems general, particular. Currently, several strategies have applied to combat infection pathogens, one them the use eco-friendly chemical compounds induce systemic resistance. Few studies addressed biocontrol agent diseases caused viruses. Exogenous treatments used reduce incidence virus diseases, reducing symptoms, titer, even eradicating proliferation Tobacco Mosaic Virus, Apple Stem Grooving Rice Stripe Virus Alfalfa tomato, apple, rice eggplant, respectively. The possibilities using possible natural are discussed.

Language: Английский

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The role of phytomelatonin receptor 1-mediated signaling in plant growth and stress response

Frontiers in Plant Science, Journal Year: 2023, Volume and Issue: 14

Published: March 10, 2023

Phytomelatonin is a pleiotropic signaling molecule that regulates plant growth, development, and stress response. In cells, phytomelatonin synthesized from tryptophan via several consecutive steps are catalyzed by decarboxylase (TDC), tryptamine 5-hydroxylase (T5H), serotonin N -acyltransferase (SNAT), -acetylserotonin methyltransferase (ASMT) and/or caffeic acid-3- O -methyltransferase (COMT). Recently, the identification of receptor PMTR1 in Arabidopsis has been considered turning point research, with function signal emerging as receptor-based regulatory strategy. addition, homologs have identified species found to regulate seed germination seedling stomatal closure, leaf senescence, responses. this article, we review recent evidence our understanding PMTR1-mediated pathways under environmental stimuli. Based on structural comparison melatonin 1 (MT1) human homologs, propose similarity three-dimensional structure receptors probably represents convergent evolution recognition different species.

Language: Английский

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PHGD: An integrative and user‐friendly database for plant hormone‐related genes

iMeta, Journal Year: 2024, Volume and Issue: 3(1)

Published: Jan. 8, 2024

Plant Hormone Gene Database (PHGD) database platform construction pipeline. First, we collected all reported hormone-related genes in the model plant Arabidopsis thaliana, and combined with existing experimental background, mapped hormone–gene interaction network to provide a blueprint. Next, 469 high-quality genomes. Then, bioinformatics was used identify these plants. Finally, genetic data were programmed be stored website PHGD built. divided into eight modules, namely Home, Browse, Search, Resources, Download, Tools, Help, Contact. We provided resources services facilitate study of hormones. hormones are small amounts organic compounds produced by plants, which can promote or inhibit diverse physiological processes [1-3]. mainly include auxin (AUX), ethylene (ETH), cytokinin (CK), abscisic acid (ABA), gibberellin (GA), brassinosteroids (BRs), jasmonic (JA), strigolactones (SLs), salicylic (SA), melatonin (MT), polypeptide (PEP) [4-6]. Each kind hormone plays its role environmental response, defense growth, development [7]. For example, CKs have been implicated cell division, root bud development, senescence, chloroplast [8]. Polypeptide play important roles adaptation environment, including precursor peptide (PROPEP) [9, 10], phytosulfokine-α (PSK) [11, 12], Ralf-like (RALF) [13], epidermal patterning factor/epidermal factor-like (EPF/EPFL) [14], clavata3/ESR-related (CLE) [15], growth factor (RGF) [16]. MT an different aspects such as salt drought stresses [17, 18]. Moreover, they interact each other form huge regulate various biological [19, 20]. instance, has crosstalk SA, JA, AUX, ABA, further contributed disease resistance [21]. involved variety pathway mechanisms, biosynthesis, metabolism, perception, signal transduction, transport pathways [22, 23]. Therefore, it is very difficult comprehensively analyze complex action mechanism Much work done contribute exploring some four main signaling reported, that is, inhibitor response 1/auxin F-boxes (TIR1/AFBs)-auxin/indole-3-acetic (AUX/IAA)-auxin factors (ARFs) [24], transmembrane kinase 1 (TMK1)-IAA32/34-ARFs [25], TMK1/auxin-binding protein1 (TMK1/ABP1)-rho-related protein from plants 2/6 (ROP2/6)-pin-formeds (PINs) [26], S-phase kinase-associated 2a (SKP2A)-Arabidopsis thaliana homolog e2f c/ATDPB (E2FC/DPB) [27]. Nevertheless, last proposed for many years, but highly controversial requires more evidence In addition, enzymes biosynthesis tryptophan decarboxylase (TDC), tryptamine 5-hydroxylase (T5H), serotonin N-acetyltransferase (SNAT), acetyl methyl transferase (ASMT) [28, 29]. However, transduction still not clear. also needs explored. The mechanisms lots human verification, so large time-consuming work. Another effective approach through big resource integration analysis. At present, only few related databases released about Among them, GSHR (Gene Set-Level Analyses Responses Arabidopsis, http://bioinfo.cemps.ac.cn/GSHR/) information [30]. one (https://plant-hormones.info/) currently unavailable. As far know, date, there no showing distribution 11 large-scale kingdoms, involving pathways. comprehensive described hormones, using methods search Based on deletion lower origin data-sharing established help researchers genes. All A. manually screened literature TAIR (https://www.arabidopsis.org/index.jsp). Initially, performed PubMed, Web Science, Google Scholar keywords "AUX," "ABA," "plant hormone," "phytohormone," "Arabidopsis," "phytohormone pathway." retrieved publications then preliminarily checked eliminate false-positive papers. phytohormone information, Kyoto Encyclopedia Genes Genomes consulted addition literature. sorted out 914 973 publications, crucial (Supporting Information S1: Tables S1 S2). After serial genome collection filtering, species gene annotation this study, 314 dicots, 85 monocots, six magnoliids, three basal angiosperms, gymnosperms, ferns, bryophytes, 39 algae (one glaucophyte, prasinodermophyte new 2020 [31], red algae, 22 green seven charophytes) S3 S4). same time, flowering (408) nonflowering (61) species. gff files, coding sequences (CDSs), examined downloaded according (https://www.plabipd.de/plant_genomes_pn.ep), identifying constructed 11-type components (Figure 1A). Furthermore, multiple effects, defense, stress, heat stomatal closure, branching, vascular included. A total 104 nodes found network. these, 49 lines connected infinitely interactions. regulatory enabled us understand systematically. Combined references, selected thaliana. lonely guy (LOG) isopentenyltransferase (IPT) key rate-limiting synthesis pathway, PURINE PERMEASE (PUP), equilibrative nucleoside transporter (ENT), ATP-binding cassette g14 (ABCG14) proteins pathway. summarized synthetic melatonin, member added recent PMTR1 receptor. PROPEP, PSK, RALF, EPF/EPFL, overexplored. domain Pfam blast (version 34.0) [32] Blast 2.10.1). members family previous reports [32-34], blastp obtain similarity relation component (E value < 1e−5). results, set filter standards higher respectively. reason setting filtering criteria relationships reference genome. Chinese cabbage theoretically times [35]. due amount loss, number identified should 1.2 2 theory, synthesized preliminary identification results determine optimal threshold [36-38] standard components. report, Chara braunii Physcomitrella patens [39]. their S5–7). obtained numbers taxa studied S8–19). 64 representative taxon display Table S20) determined node based presence counted (408 61 plants) S19). premise avoiding (11 53 counting If present species, define "1," if not, "0" S20). inferred paths statistical result. Here, CK, PEP examples. homologous AUX YUCCA (YUC) distributed proteins) land suggest originated common ancestor receptor TIR1/AFB ABP1 (Chlorella variabilis, Micractinium conductrix, Chlamydomonas reinhardtii), five charophytes (Klebsormidium nitens, C. braunii, Mesotaenium endlicherianum, Penium margaritaceum, Spirogloea muscicola), almost complete perception algae. AUX/IAAs, auxin-upregulated RNA, ARF exist Other critical ROP, Topless, TMK taxa. DPB, E2FC, SKP2A scattered among simultaneously 63 Due high controversy SKP2A/E2FC/DPB explored study. short, our indicate charophytes. AUXIN1 (AUX1)/like AUX1, PIN-formed (PIN)/PIN-likes, ABC families taxa, suggesting glaucophytes. metabolic GRETCHEN HAGEN 3 first followed K. nitens M. well These CK biosynthetic LOG IPT indicates oxidase exists indicating histidine terrestrial histidine-containing phosphotransmitter (AHP) except type-A regulators (ARRs) absent type-B ARRs glaucophytes, prasinodermophytes, charophytes, may originate prasinodermophytes. PUP two (Cyanidiococcus yangmingshanensis Cyanidioschyzon merolae), (Asterochloris glomerata, Chromochloris zofingiensis), ENT ABCG14 taxon. imply PROPEP chlorophytes (A. Coccomyxa subellipsoidea, incerta, eustigma, Edaphochlamys debaryana, Gonium pectorale, (Chlorokybus atmophyticus, P. S. chlorophytes. PSK gymnosperms gymnosperms. RALF EPF/EPFL suggests both TDC had SNAT ASMT synthase homologs (C. zofingiensis, Monoraphidium neglectum), chlorophyte (M. endlicherianum), most did find T5H sequence blast, it. According TDC, SNAT, ASMT, speculated By summarizing above-identified genes, (http://phgd.bio2db.com/) user-friendly web interface referencing [40-42]. includes types 1B). contains synthesis, receptor, signal, integrates functions networks 2A–C). overview interfaces, Contact users easily use 2A). modes "Species" "Pathway" browse 2D). mode, classified locate classification queried view table. "MORE" column table specific name, CDSs, sequences. directly "CDS" "Pro" columns clicking "Bar" "Pie," see ratio download via "Download." bar chart. Users could 2E). displayed pie research. Search contain rich (pfam id, domain, E value, family) (chromosome, start, end, annotation), section, category included 2F). Latin taxonomy, genomic published articles, links details journal, publication year, authors. popular tools, Primer Design, perform analysis 2G). tool conduct CDS alignment. built alignment copying frame uploading Fasta format. developed Design design primers assigned Download demands research 2H). address, email, phone contact any questions 2I). detailed manual video know how 2J). encourage submit enrich database. examples evolutionary AHP belonging cabbage. target page, relevant interest (AHP 3A). file species' page 3B). verification [32], SMART 9, https://smart.embl.de) [43], CDD 3.17, https://www.ncbi.nlm.nih.gov/Structure/cdd/cdd.shtml) [44], members, consistent report [45]. neighbor-joining method phylogenetic tree MEGA X software [46]. previously [47-49], expansion cabbage, Brassica oleracea, napus carried 3C–E). multiploidy experienced 3F), relationship between B. 1:3:3:6 [49]. showed corresponding lost. six, eight, 16, hybrid sum oleracea equal napus. combination trees, indirect caused hybridization, while direct duplication. To explore trajectory Oryza sativa, Aristolochia fimbriata, Amborella trichopoda, Picea abies, Selaginella moellendorffii, patens, reinhardtii) kingdom platform. Mafft 7.475) [50] FastTree 2.1) construct 3G) [51]. Notung 2.9.1.5) duplication loss [52]. size ancestral [53] 3H). show ancestors reinhardtii contained serious lost zero obtained. Seven moellendorfii lost, obtained, seed angiosperm nine eudicot monocot From exhibits pattern. extensive investigations, integrated studies map components, closely at least providing core interactions overall blueprint regulation development. searches, plants). data, assist people PHGD, effect example. Currently, available GSHR, dedicated service already greatly Compared focuses severely limits whose genomes sequenced far, studying enough terms types. updated since 2018, lacking GSHR. Although makes up above deficiencies, lack functional validation, provides breeders. Researchers in-depth needs. Overall, resources, will future, release innovation research, continue improve update conclusion, Through genomes, continuously newly assembled believe become world. Xiaoming Song conceived project responsible initiation. Song, Shuyan Feng, Zhuo Liu, Xiao Ma supervised managed bioinformatic analyses led Huilong Chen, Ma. Tong Yu, Ma, Fulei Nie. manuscript organized, written, revised Nan Li, Di Guo. Rong Zhou. authors read approved manuscript. This supported National Key Research Development Program China (2023YFF1002000), Natural Science Foundation Distinguished Young Hebei Province (C2022209010), (32172583), (C2021209005, C2021209019), Laboratory Nucleic Research, Tangshan (2022TS003b). declare conflict interest. sets (http://phgd.bio2db.com/). Supplementary materials (figures, tables, scripts, graphical abstract, slides, videos, translated version materials) online DOI iMeta http://www.imeta.science/. sources S2: description S3: classification, source, S4: S5: structural S6: display. S7: S8: ABA pfam identification. S9: S10: BR S11: S12: ETH S13: GA S14: JA S15: SA S16: SL S17: filter. S18: POLYPEPTIDE S19: S20: heatmap Please note: publisher content functionality supporting supplied Any queries (other than missing content) directed author article.

Language: Английский

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Have All of the Phytohormonal Properties of Melatonin Been Verified?

International Journal of Molecular Sciences, Journal Year: 2024, Volume and Issue: 25(6), P. 3550 - 3550

Published: March 21, 2024

Melatonin is a ubiquitous regulator in plants and performs variety of physiological roles, including resistance to abiotic stress, regulation growth development, enhancement plant immunity. exhibits the characteristics phytohormone with its pleiotropic effects, biosynthesis, conjugation, catabolism, effective concentration, shape location dose-response curves. In addition, CAND2/PMTR1, phytomelatonin receptor candidate belonging G protein-coupled receptors (GPCRs), supports concept melatonin as phytohormone. However, biochemistry needs be further characterized. particular, some experimental findings date cannot explained by known GPCR signaling mechanisms, so studies are needed explore possibility novel mechanisms.

Language: Английский

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Melatonin functions as a broad‐spectrum antifungal by targeting a conserved pathogen protein kinase

Journal of Pineal Research, Journal Year: 2022, Volume and Issue: 74(1)

Published: Oct. 31, 2022

Melatonin is a low-cost natural small indole molecule with versatile biological functions. However, melatonin's fungicidal potential has not been fully exploited, and the mechanism remains elusive. Here, we report that melatonin broadly inhibited 13 plant pathogens. In rice blast fungal pathogen Magnaporthe oryzae, growth, formation of infection-specific structures named appressoria, infection, reducing disease severity. entered cells efficiently colocalized critical mitogen-activated protein kinase Mps1, suppressing phosphorylation Mps1. Melatonin's affinity for Mps1 via two hydrogen bonds was demonstrated using surface plasmon resonance chemical modifications. To improve efficiency, obtained 20 derivatives. Tert-butyloxycarbonyl showed 25-fold increase in activities, demonstrating feasibility modifications modification. Our study broad-spectrum effect by as one targets. Through further systematic modifications, developing an eco-friendly derivative commercial values agricultural applications appears promising.

Language: Английский

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Phytomelatonin: an emerging new hormone in plants

Journal of Experimental Botany, Journal Year: 2022, Volume and Issue: 73(17), P. 5773 - 5778

Published: Sept. 29, 2022

Language: Английский

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Genetic and evolutionary dissection of melatonin response signaling facilitates the regulation of plant growth and stress responses

Journal of Pineal Research, Journal Year: 2022, Volume and Issue: 74(2)

Published: Dec. 31, 2022

Abstract The expansion of gene families during evolution could generate functional diversity among their members to regulate plant growth and development. Melatonin, a phylogenetically ancient molecule, is vital for many aspects plant's life. Understanding the molecular players involved in melatonin biosynthesis, signaling, metabolism will facilitate regulation phenotypes. However, mechanism response signaling elements regulating this network still has challenges. Here, we provide an in‐depth analysis components pathway. Genetic multiple mutants species shed light on role regulatory pathways. Phylogenetic these genes was performed, which identification melatonin‐related future study. Based abovementioned signal networks, summarized reference studying We hope that work research higher plants finely tuned spatio‐temporal signaling.

Language: Английский

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Microbe-mediated nanoparticle intervention for the management of plant diseases

Crop Health, Journal Year: 2023, Volume and Issue: 1(1)

Published: Aug. 10, 2023

Abstract Plant diseases are caused by various pathogenic microorganisms, leading to substantial economic losses and food insecurity worldwide. However, the extensive use of chemical-based nanopesticides has adverse effects on plants, soil, environmental systems. There is increasing interest in developing eco-friendly sustainable alternatives manage plant diseases. Recently, microbe-mediated nanoparticles (NPs) as have attracted cultivators, specifically disease management, compared traditional physical chemical approaches. This review focuses state-of-the-art formulations using microorganisms against bacterial fungal phytopathogens. The article discusses mechanisms through which these microbes contribute enhanced effectiveness NPs, including production bioactive compounds, improved nanoparticle synthesis, facilitation targeted delivery. also highlights advantages nanopesticides, such reduced toxicity, increased biodegradability, potential pesticide-resistant pathogens. Overall, NPs an inexpensive, reliable, approach for management.

Language: Английский

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