Eucommia folium can be prepared into tea with the ability to prevent and treat hyperuricemia DOI Creative Commons
Qing Hao, Ying Liu, Zhen Zhai

et al.

Research Square (Research Square), Journal Year: 2024, Volume and Issue: unknown

Published: Nov. 2, 2024

Abstract The aim of this study was to investigate the antihyperuricaemic (HUA) effect Eucommia folium after preparing a tea made from its leaves (abbreviated as DZ) which has ability prevent and treat HUA. In study, mouse HUA model established via gavage potassium oxonate hypoxanthine, treated with DZ therapeutic on This recruited 30 volunteers, who drank 10 g daily for 4 consecutive weeks. serum levels UA volunteers were measured once per week observe anti-HUA efficacy at clinical level. Animal experiments have shown that effects effectively reduces uric acid (UA), creatinine (Cr), urea nitrogen (BUN) in mice; decreases xanthine oxidase (XOD) activity serum; alleviates damage kidney tissues glomeruli. Metabolomic analysis revealed affects multiple metabolites, such orotidine, orotic acid, ureidosuccinic 1-methylhistidine, other these metabolites are involved mainly pyrimidine metabolism, histidine riboflavin metabolism. Clinical research that, consumed, significantly decreased. can HUA, is same class traditional Chinese medicines used medicine food, extremely low toxicity high safety. Therefore, suitable functional food prevention treatment

Language: Английский

Geographical variation in metabolite profiles and bioactivity of Thesium chinense Turcz. revealed by UPLC-Q-TOF-MS-based metabolomics DOI Creative Commons
Fang Zhang, Guanglei Zhang, Cong Wang

et al.

Frontiers in Plant Science, Journal Year: 2025, Volume and Issue: 15

Published: Jan. 10, 2025

This study aims to investigate the impact of geographical origin on metabolite composition and bioactivity Thesium chinense Turcz. (TCT), a member Apiaceae family renowned for its wide range pharmacological properties, including antioxidant, antimicrobial, anti-inflammatory effects. In this study, we investigated whole plants TCT from different regions in China, aiming explore variation TCT. A non-targeted metabolomics approach was employed using ultra-high-performance liquid chromatography combined with quadrupole time-of-flight mass spectrometry (UPLC-Q-TOF-MS). Principal component analysis (PCA) partial least squares discriminant (PLS-DA) were utilized identify differentiate profiles. We bioactivity, antioxidant activity, total flavonoid content (TFC), characteristic compounds sourced regions. further metabolic differences quality characteristics various origins. PCA PLS-DA analyses indicated that samples origins could be clearly distinguished. The revealed 54 differential metabolites, predominantly flavonoids alkaloids. KEGG pathway significant variations biosynthesis pathways flavanols among samples. Anhui province exhibited highest TFC strongest activities, while Jilin showed lowest. strong correlation observed between origins, suggesting is significantly influenced by provenance. Additionally, activities validated, showing predictive relationship TFC. research highlights potential discerning subtleties plant metabolomes, contributing advancement traditional Chinese medicine integration into modern healthcare practices.

Language: Английский

Citations

0
Eucommia folium can be Prepared as a Tea with the Ability to Prevent and Treat Hyperuricaemia DOI
Qing Hao, Ying Liu, Zhen Zhai

et al.

Plant Foods for Human Nutrition, Journal Year: 2025, Volume and Issue: 80(2)

Published: March 18, 2025

Language: Английский

Citations

0
Drug or Toxic? A Brief Understanding of the Edible Corolla of Rhododendron decorum Franch. by Bai Nationality with Comparative Metabolomics Analysis DOI Creative Commons
Weiwei Liu, Ling Wang,

Chenghua Yu

et al.

Metabolites, Journal Year: 2024, Volume and Issue: 14(9), P. 484 - 484

Published: Sept. 4, 2024

is a traditional ornamental and medicinal plant in China, renowned for its aesthetic appeal therapeutic properties. Regarding

Language: Английский

Citations

1
Multi-omics study of plant callus cultures DOI Open Access
June‐Sik Kim,

Muneo Sato,

Mikiko Kojima

et al.

Plant Biotechnology, Journal Year: 2024, Volume and Issue: 41(3), P. 309 - 314

Published: Sept. 17, 2024

Callus cultures are fundamental for plant propagation, genetic transformation, and emerging biotechnological applications that use cellular factories to produce high-value metabolites like plant-based drugs. These exploit the diverse metabolic capabilities of various species. However, optimizing culture conditions specific necessitates a deep understanding transcriptome, metabolome, phytohormone profiles different Comprehensive comparative studies callus characteristics across species limited. Here, we analyzed from tobacco (Nicotiana tabacum), rice (Oryza sativa), two bamboo (Phyllostachys nigra P. bambusoides). Multivariate analyses metabolome data revealed similar trends in these identified differ between Hormone profiling showed distinct species-specific patterns notable cytokinin diversity, even Moreover, analysis 8,256 pairs syntenic genes 84.7% orthologs differential expression, indicating significant transcriptomic diversity despite phylogenomic relatedness. Transcriptional regulation developing organs often involves conserved gene expression species; however, our findings suggest formation may relax evolutionary constraints on regulatory programs. results illustrate molecular multiple species, emphasizing need map this variability comprehensively fully potential cultures.

Language: Английский

Citations

1
Geographical Variation in Metabolite Profiles and Bioactivity of Thesium Chinense Turcz. Revealed by Uhplc-Q/Tof-Ms-Based Metabolomics DOI
Guanglei Zhang,

Fang Zhang,

Haonan Xu

et al.

Published: Jan. 1, 2024

Language: Английский

Citations

0
Editorial: Plant secondary metabolite biosynthesis DOI Creative Commons

Xiang Pu,

Naoki Kitaoka,

Carlos E. Rodríguez López

et al.

Frontiers in Plant Science, Journal Year: 2024, Volume and Issue: 15

Published: Aug. 21, 2024

Keywords: plant, secondary metabolite, biosynthetic pathway, gene characterization, synthetic biotechnology

Language: Английский

Citations

0
Eucommia folium can be prepared into tea with the ability to prevent and treat hyperuricemia DOI Creative Commons
Qing Hao, Ying Liu, Zhen Zhai

et al.

Research Square (Research Square), Journal Year: 2024, Volume and Issue: unknown

Published: Nov. 2, 2024

Abstract The aim of this study was to investigate the antihyperuricaemic (HUA) effect Eucommia folium after preparing a tea made from its leaves (abbreviated as DZ) which has ability prevent and treat HUA. In study, mouse HUA model established via gavage potassium oxonate hypoxanthine, treated with DZ therapeutic on This recruited 30 volunteers, who drank 10 g daily for 4 consecutive weeks. serum levels UA volunteers were measured once per week observe anti-HUA efficacy at clinical level. Animal experiments have shown that effects effectively reduces uric acid (UA), creatinine (Cr), urea nitrogen (BUN) in mice; decreases xanthine oxidase (XOD) activity serum; alleviates damage kidney tissues glomeruli. Metabolomic analysis revealed affects multiple metabolites, such orotidine, orotic acid, ureidosuccinic 1-methylhistidine, other these metabolites are involved mainly pyrimidine metabolism, histidine riboflavin metabolism. Clinical research that, consumed, significantly decreased. can HUA, is same class traditional Chinese medicines used medicine food, extremely low toxicity high safety. Therefore, suitable functional food prevention treatment

Language: Английский

Citations

0