Melatonin as a natural ally against oxidative stress: a physicochemical examination

Journal of Pineal Research, Journal Year: 2011, Volume and Issue: 51(1), P. 1 - 16

Published: June 14, 2011

Abstract: Oxidative stress has been proven to be related the onset of a large number health disorders. This chemical is triggered by an excess free radicals, which are generated in cells because wide variety exogenous and endogenous processes. Therefore, finding strategies for efficiently detoxifying radicals become subject great interest, from both academic practical points view. Melatonin ubiquitous versatile molecule that exhibits most desirable characteristics good antioxidant. The amount data gathered so far regarding protective action melatonin against oxidative overwhelming. However, rather little known concerning mechanisms involved this activity. review summarizes current progress understanding physicochemical insights radical–scavenging activity melatonin. Thus far, there general agreement electron transfer hydrogen main reactions with radicals. relative importance other also analyzed. nature reacting radical influence on different these reactions. point discussed detail review. Based available data, it concluded protects mechanisms. Moreover, proposed even though referred as expression darkness, perhaps could light health.

Language: Английский

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Extrapineal melatonin: sources, regulation, and potential functions

Cellular and Molecular Life Sciences, Journal Year: 2014, Volume and Issue: 71(16), P. 2997 - 3025

Published: Feb. 19, 2014

Language: Английский

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Melatonin—A pleiotropic, orchestrating regulator molecule

Progress in Neurobiology, Journal Year: 2010, Volume and Issue: 93(3), P. 350 - 384

Published: Dec. 29, 2010

Language: Английский

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Functions of melatonin in plants: a review

Journal of Pineal Research, Journal Year: 2015, Volume and Issue: 59(2), P. 133 - 150

Published: June 19, 2015

The number of studies on melatonin in plants has increased significantly recent years. This molecule, with a large set functions animals, also shown great potential plant physiology. review outlines the main physiology higher plants. Its role as antistress agent against abiotic stressors, such drought, salinity, low and high ambient temperatures, UV radiation toxic chemicals, is analyzed. latest data their plant-pathogen interactions are discussed. Both biotic stresses produce significant increase endogenous levels, indicating its possible effector these situations. existence circadian rhythms levels been demonstrated some species, data, although limited, suggest central this molecule day/night cycles Finally, another aspect that led to volume research involvement aspects development regulation. Although hormone still far from being fully established, processes growth, rhizogenesis, photosynthesis seems evident. multiple changes gene expression caused by point multiregulatory capable coordinating many development. last aspect, together an alleviating-stressor agent, suggests excellent prospect for crop improvement.

Language: Английский

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Roles of melatonin in abiotic stress resistance in plants

Journal of Experimental Botany, Journal Year: 2014, Volume and Issue: 66(3), P. 647 - 656

Published: Aug. 14, 2014

In recent years melatonin has emerged as a research highlight in plant studies. Melatonin different functions many aspects of growth and development. The most frequently mentioned are related to abiotic stresses such drought, radiation, extreme temperature, chemical stresses. This review mainly focuses on the regulatory effects when plants face harsh environmental conditions. Evidence indicates that stress can increase level endogenous plants. Overexpression biosynthetic genes elevates levels transgenic show enhanced tolerance Exogenously applied also improve ability tolerate mechanisms by which alleviates discussed.

Language: Английский

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Melatonin: plant growth regulator and/or biostimulator during stress?

Trends in Plant Science, Journal Year: 2014, Volume and Issue: 19(12), P. 789 - 797

Published: Aug. 22, 2014

Language: Английский

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Functional roles of melatonin in plants, and perspectives in nutritional and agricultural science

Journal of Experimental Botany, Journal Year: 2011, Volume and Issue: 63(2), P. 577 - 597

Published: Oct. 20, 2011

The presence of melatonin in plants is universal. Evidence has confirmed that a major portion the synthesized by themselves even though homologue classic arylalkylamine N-acetyltransferase (AANAT) not been identified as yet plants. Thus, serotonin N-acetylating enzyme may differ greatly from animal AANAT with regard to sequence and structure. This would imply multiple evolutionary origins enzymes these catalytic properties. A primary function serve first line defence against internal environmental oxidative stressors. much higher levels compared those found animals are thought be compensatory response which lack means mobility, unlike animals, coping harsh environments. Importantly, remarkably high concentrations have measured popular beverages (coffee, tea, wine, beer) crops (corn, rice, wheat, barley, oats). Billions people worldwide consume products daily. beneficial effects on human health derived consumption must considered. also indicates an ability increase production crops. mechanisms involve roles preservation chlorophyll, promotion photosynthesis, stimulation root development. Transgenic enhanced content could probably lead breakthroughs crop agriculture improve general humans.

Language: Английский

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Chemical Priming of Plants Against Multiple Abiotic Stresses: Mission Possible?

Trends in Plant Science, Journal Year: 2015, Volume and Issue: 21(4), P. 329 - 340

Published: Dec. 18, 2015

Language: Английский

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Extrapineal melatonin: analysis of its subcellular distribution and daily fluctuations

Journal of Pineal Research, Journal Year: 2011, Volume and Issue: 52(2), P. 217 - 227

Published: Aug. 3, 2011

We studied the subcellular levels of melatonin in cerebral cortex and liver rats under several conditions. The results show that cell membrane, cytosol, nucleus, mitochondrion vary over a 24-hr cycle, although these variations do not exhibit circadian rhythms. membrane has highest concentration followed by mitochondria, cytosol. Pinealectomy significantly increased content all compartments, whereas luzindole treatment had little effect on levels. Administration 10 mg/kg bw to sham-pinealectomized, pinealectomized, or continuous light-exposed compartments. Melatonin doses ranging from 40 200 dose-dependent manner accumulation accumulations were times greater former than latter. nucleus mitochondria reached saturation with dose bw; higher injected did further cause additional organelles. suggest some control extrapineal production support existence regulatory mechanisms cellular organelles, which prevent intracellular equilibration indolamine. Seemingly, different concentrations can be maintained data also seem requirement high obtain therapeutic effects. Together, add information assists explaining physiology pharmacology melatonin.

Language: Английский

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Protective effects of melatonin in reducing oxidative stress and in preserving the fluidity of biological membranes: a review

Journal of Pineal Research, Journal Year: 2014, Volume and Issue: 56(3), P. 225 - 237

Published: Feb. 26, 2014

Abstract Free radicals generated within subcellular compartments damage macromolecules which lead to severe structural changes and functional alterations of cellular organelles. A manifestation free radical injury biological membranes is the process lipid peroxidation, an autooxidative chain reaction in polyunsaturated fatty acids membrane are substrate. There considerable evidence that tends reduce fluidity. However, adequate levels fluidity essential for proper functioning membranes. Thus, there interest antioxidant molecules able stabilize because their protective effects against peroxidation. Melatonin indoleamine modulates a wide variety endocrine, neural immune functions. Over last two decades, intensive research has proven this molecule, as well its metabolites, possess substantial activity. In addition ability scavenge several reactive oxygen nitrogen species, melatonin increases activity glutathione redox enzymes, is, peroxidase reductase, other enzymes. These beneficial more significant small molecular size amphipathic behaviour, facilitates ease penetration into every compartment. present work, we review current information related maintaining attack, further, discuss implications ageing disease.

Language: Английский

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