Three-Month Durability of Bilateral Two-Level Stellate Ganglion Blocks in Patients with Generalized Anxiety Disorder: A Retrospective Analysis

Brain Sciences, Journal Year: 2025, Volume and Issue: 15(2), P. 188 - 188

Published: Feb. 13, 2025

Purpose: Determine if performing ultrasound-guided, bilateral, two-level cervical sympathetic chain blocks (2LCSB) (performed on subsequent days) provides durable improvement in symptoms associated with anxiety. Methods: A retrospective chart review was conducted between January 2022 and November 2024. We identified 114 patients who received 2LCSB for anxiety symptoms. Generalized Anxiety Disorder 7-Item Scale (GAD-7) outcome measure scores were collected at baseline three-months post procedure 71 males 43 females. Results: Out of patients, 99 (86.8%) showed a long-lasting their GAD-7 scores. Collected forms had average 15.52 (14.99 16.40 females), which decreased after three months to an 7.28 (6.96 7.81 females). This represents 52% Conclusions: In individuals treated 2LCSB, GAD-related improved by least 3 regardless initial severity.

Language: Английский

Treating Post-Traumatic Stress Disorder in Canadian Special Operation Forces Command With Ketamine Plus Cervical Sympathetic Blockade

Military Medicine, Journal Year: 2025, Volume and Issue: unknown

Published: Feb. 27, 2025

Canadian Special Operation Forces Command (CANSOFCOM) operators have been extensively deployed in recent conflicts. They are at risk of trauma and blast exposure as well the development post-traumatic stress disorder (PTSD) traumatic brain injury (bTBI). Current psychotherapy pharmacological approaches provide suboptimal resolution PTSD bTBI symptoms. Prior research has shown that ketamine infusion cervical sympathetic blockade (CSB) reduced A total 11 patients, including CANSOFCOM members, were treated followed. Pre- post-intervention Checklist-5 Neurobehavioral Inventory Scale (NSI) scores recorded. questionnaire was administered only to patients with a history injury. Each patient received 4 bilateral CSB treatments, per previously published by IRB protocol #00000971. Two weeks post-intervention, average Checklist score reduction 45.09 (n = 11). NSI 40.7 (87.0% reduction) 6). No other available. These findings highlight importance early intervention ongoing evaluation treatment. Ketamine combined can clinically significant cohort. Of interest, another study alone treatment bTBI, which used assessment, showed 53% on 1-month follow-up. Our report demonstrated an 87% 2 weeks. Possible physiological explanations limitations discussed.

Language: Английский

The Effect of Bilateral, Two-Level Cervical Sympathetic Chain Blocks on Specific Symptom Clusters for Traumatic Brain Injury, Independent of Concomitant PTSD Symptoms

Brain Sciences, Journal Year: 2024, Volume and Issue: 14(12), P. 1193 - 1193

Published: Nov. 27, 2024

Background/Objectives: The aim of this study was to determine if performing ultrasound-guided, bilateral, two-level cervical sympathetic chain blocks (2LCSBs) (performed on subsequent days) improves symptoms associated with traumatic brain injury (TBI) that do not overlap posttraumatic stress disorder (PTSD). Methods: A retrospective chart review conducted between August 2022 and February 2023. We identified twenty patients who received bilateral 2LCSBs for PTSD anxiety also had a history TBI. Neurobehavioral Symptom Inventory (NSI) scores were collected at baseline, one week, month post treatment in 13 males 7 females. sub-analysis the first ten questions NSI, which we as overlapping or symptoms, generated an NSI sub-score. Results: Out 20 patients, all showed improvement their sub-scores. sub-scores baseline average 15.45 (on 40-point scale); score week 8.30; 7.80. This represents 49.51% TBI did month. Conclusions: use may be helpful treating TBI, regardless presence comorbid symptoms.

Language: Английский