Understanding the Genetic Basis of Variation in Meiotic Recombination: Past, Present, and Future

Molecular Biology and Evolution, Journal Year: 2024, Volume and Issue: 41(7)

Published: July 1, 2024

Meiotic recombination is a fundamental feature of sexually reproducing species. It often required for proper chromosome segregation and plays important role in adaptation the maintenance genetic diversity. The molecular mechanisms are remarkably conserved across eukaryotes, yet meiotic genes proteins show substantial variation their sequence function, even between closely related Furthermore, rate distribution shows huge diversity within chromosomes, individuals, sexes, populations, This has implications many evolutionary processes, how why this evolved not well understood. A key step understanding trait evolution to determine its basis-that is, number, effect sizes, loci underpinning variation. In perspective, I discuss past current knowledge on basis distribution, explore implications, present open questions future research.

Language: Английский

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Multi‐environment association study highlights candidate genes for robust agronomic quantitative trait loci in a novel worldwide Capsicum core collection

The Plant Journal, Journal Year: 2023, Volume and Issue: 116(5), P. 1508 - 1528

Published: Aug. 21, 2023

Investigating crop diversity through genome-wide association studies (GWAS) on core collections helps in deciphering the genetic determinants of complex quantitative traits. Using G2P-SOL project world collection 10 038 wild and cultivated Capsicum accessions from major genebanks, we assembled a 423 representing known diversity. Since traits are often highly dependent upon environmental variables genotype-by-environment (G × E) interactions, multi-environment GWAS with 195-marker genotypic matrix were conducted diverse subset 350 annuum accessions, extensively phenotyped up to six independent trials five climatically differing countries. Environment-specific trait loci (QTLs) detected for 23 agronomic We identified 97 candidate genes potentially implicated 53 most robust high-confidence QTLs fruit flavor, color, size, shape traits, plant productivity, vigor, earliness architecture this way will assist development markers pave marker-assisted selection. The pepper be available request as unique universal resource further exploitation future gene discovery breeding efforts by community.

Language: Английский

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Recombination Landscape Divergence Between Populations is Marked by Larger Low-Recombining Regions in Domesticated Rye

Molecular Biology and Evolution, Journal Year: 2022, Volume and Issue: 39(6)

Published: June 1, 2022

Abstract The genomic landscape of recombination plays an essential role in evolution. Patterns are highly variable along chromosomes, between sexes, individuals, populations, and species. In many eukaryotes, rates elevated sub-telomeric regions drastically reduced near centromeres, resulting large low-recombining (LR) regions. processes influenced by genetic factors, such as different alleles genes involved meiosis chromatin structure, well external environmental stimuli like temperature overall stress. this work, we focused on the landscapes a collection 916 rye (Secale cereale) individuals. By analyzing population structure among individuals domestication status geographic origin, detected high levels admixture, reflecting reproductive biology self-incompatible, wind-pollinating grass We then analyzed patterns overlapping subpopulations, which revealed substantial variation physical size LR regions, with tendency for larger domesticated subpopulations. Genome-wide association scans (GWAS) region major quantitative-trait-locus (QTL) at which, 18 annotated genes, ortholog histone H4 acetyltransferase ESA1 was located. Rye belonging to subpopulations showed increased synaptonemal complex length, but no difference crossover frequency, indicating that only is different. Furthermore, harboring ScESA1 moderate selection suggesting were indirectly selected during achieve more homogeneous populations agricultural use.

Language: Английский

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Independent genetic basis of meiotic crossover positioning and interference in domestic pigs

Scientific Reports, Journal Year: 2025, Volume and Issue: 15(1)

Published: March 18, 2025

Abstract Meiotic crossover patterning shows huge variation within and between chromosomes, individuals, species, yet the molecular evolutionary causes consequences of this remain poorly understood. A key step is to understand genetic architecture rate, positioning, interference determine if these factors are governed by common or distinct processes. Here, we investigate individual in autosomal count, position (measured as both intra-chromosomal shuffling distance telomere), a large breeding population domestic pigs ( N = 82,474 gametes). We show that all traits heritable females at gamete (h 2 0.07–0.11) mean levels 0.08–0.41). In females, strongly associated with RNF212 , but positioning SYCP2 MEI4 PRDM9 . Our results rate/interference driven processes female have capacity evolve independently.

Language: Английский

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Mixed Outcomes in Recombination Rates After Domestication: Revisiting Theory and Data

Molecular Ecology, Journal Year: 2025, Volume and Issue: unknown

Published: April 24, 2025

ABSTRACT The process of domestication has altered many phenotypes. Selection on these phenotypes long been hypothesised to indirectly select for increases in the genome‐wide recombination rate. This hypothesis is potentially consistent with theory evolution rate, but empirical support unclear. We review relevant theory, lab‐based experiments, and data comparing rates wild progenitors their domesticated counterparts. utilise population sequencing a deep learning method infer new comparisons chicken/red junglefowl, sheep/mouflon, goat/bezoar. find evidence increased goats compared bezoars more mixed results chicken generally decreased sheep mouflon. Our add growing body literature plants animals that finds no an increase domestication.

Language: Английский

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Mating system and the evolution of recombination rates in seed plants

Journal of Evolutionary Biology, Journal Year: 2025, Volume and Issue: unknown

Published: May 5, 2025

Abstract Meiotic recombination is a central mechanism underlying sexual reproduction among eukaryotes. In many species, the rate strongly constrained by chromosome size, as number of crossovers per generally ranges between one and no more than few (around three to five). Yet, rates are variable can evolve in particular when they differ their reproductive system. According theory, indirect selection towards higher expected be stronger inbred populations, such selfing species compared with randomly mating species. To test for impact system on evolution rates, we leveraged dataset genetic maps, genome sizes, numbers, life history traits 200 seed plant After controlling size effect, phylogeny, map quality, found joint positive effect longevity mixed-mating We also that had significantly larger chromosomes outcrossing suggesting relaxed crossover interference these former Our results point an important factor potentially shaping despite mechanical constraints acting chromosome.

Language: Английский

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Fine mapping of meiotic crossovers in Brassica oleracea reveals patterns and variations depending on direction and combination of crosses

The Plant Journal, Journal Year: 2023, Volume and Issue: 113(6), P. 1192 - 1210

Published: Jan. 10, 2023

SUMMARY Meiotic recombination is crucial for assuring proper segregation of parental chromosomes and generation novel allelic combinations. As this process tightly regulated, identifying factors influencing rate, distribution meiotic crossovers (COs) major importance, notably plant breeding programs. However, high‐resolution maps are sparse in most crops including the Brassica genus knowledge about intraspecific variation sex differences lacking. Here, we report fine‐scale resolution landscapes 10 female male crosses oleracea , by analyzing progenies five large four‐way‐cross populations from two reciprocally crossed F1s per population. Parents highly diverse inbred lines representing crops, broccoli, cauliflower, cabbage, kohlrabi, kale. We produced approximately 4.56T Illumina data 1248 identified 15 353 CO across reciprocal crosses, 51.13% which being mapped to <10 kb. revealed fairly similar Mb‐scale among all cross combinations between sexes, provided evidence that these largely independent sequence divergence. evidenced strong influence gene density structural variations on formation B. . Moreover, found extensive number depending direction combination initial parents with, first time, a striking interdependency factors. These improve our current important breeders.

Language: Английский

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Heterochromatin in plant meiosis

Nucleus, Journal Year: 2024, Volume and Issue: 15(1)

Published: March 15, 2024

Heterochromatin is an organizational property of eukaryotic chromosomes, characterized by extensive DNA and histone modifications, that associated with the silencing transposable elements repetitive sequences. Maintaining heterochromatin crucial for ensuring genomic integrity stability during cell cycle. During meiosis, important homologous chromosome synapsis, recombination, segregation, but our understanding meiotic formation condensation limited. In this review, we focus on dynamics features how it condenses meiosis in plants. We also discuss influences interaction recombination chromosomes prophase I.

Language: Английский

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Unintended Consequences of Plant Domestication

Plant and Cell Physiology, Journal Year: 2022, Volume and Issue: 63(11), P. 1573 - 1583

Published: June 18, 2022

Abstract Human selection on wild populations mostly favored a common set of plant traits during domestication. This process direct also altered other independent that were not directly perceived or desired crop domestication and improvement. A deeper knowledge the inadvertent undesirable phenotypic effects their underlying genetic causes can help design strategies to mitigate improve gain in plants. We review different factors explaining negative consequences at genomic levels. further describe originate from favorable alleles In addition, we propose could be useful attenuating such for With novel -omics genome-editing tools, it is relatively approachable understand manipulate biochemical mechanisms responsible phenotypes domesticated

Language: Английский

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The role of recombination landscape in species hybridisation and speciation

Frontiers in Plant Science, Journal Year: 2023, Volume and Issue: 14

Published: July 6, 2023

It is now well recognised that closely related species can hybridize and exchange genetic material, which may promote or oppose adaptation speciation. In some cases, interspecific hybridisation very common, making it surprising identity preserved despite active gene exchange. The genomes of most eukaryotic are highly heterogeneous with regard to density, abundance repetitive DNA, chromatin compactisation etc, make certain genomic regions more prone resistant introgression material from other species. Heterogeneity in local recombination rate underpins many the observed patterns across genome (e.g. actively recombining typically rich depleted for DNA) strongly affect permeability introgression. larger region lacking recombination, higher chance presence incompatibility gene(s) region, entire non- rarely block impermeable Large plant tend have landscape, frequently occurring at ends chromosomes central recombination. this paper we review relationship between plants argue large likely play a major role preserving hybridising

Language: Английский

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