Nature Communications,
Journal Year:
2022,
Volume and Issue:
13(1)
Published: Nov. 11, 2022
Abstract
Helicobacter
pylori
lives
in
the
human
stomach
and
has
a
population
structure
resembling
that
of
its
host.
However,
H.
from
Europe
Middle
East
trace
substantially
more
ancestry
modern
African
populations
than
humans
carry
them.
Here,
we
use
collection
Afro-Eurasian
genomes
to
show
this
is
due
at
least
three
distinct
admixture
events.
Asia,
which
have
undergone
little
admixture,
accumulated
many
non-synonymous
mutations
strains.
European
Eastern
bacteria
elevated
sites
these
mutations,
implying
selection
remove
them
during
admixture.
Simulations
fitness
can
be
restored
after
bottlenecks
by
migration
subsequent
small
numbers
non-bottlenecked
populations.
We
conclude
recent
spread
DNA
been
driven
deleterious
original
out-of-Africa
bottleneck.
Molecular Ecology,
Journal Year:
2025,
Volume and Issue:
unknown
Published: April 28, 2025
ABSTRACT
Hybridisation
is
a
common
feature
of
evolutionary
radiations,
but
its
genomic
consequences
vary
depending
on
when
it
occurs.
Since
reproductive
isolation
takes
time
to
accumulate,
hybridisation
can
occur
at
multiple
points
during
divergence.
Previous
studies
suggested
that
the
taxonomic
diversity
in
radiations
help
infer
timing
past
gene
flow
events.
Here,
we
assess
power
these
approaches
for
revealing
occurred
between
two
monkeyflower
taxa
(
Mimulus
aurantiacus
)
endemic
Channel
Islands
California.
Coalescent
simulations
reveal
conventional
four‐taxon
tests
may
not
be
capable
fully
distinguishing
recent
and
ancient
introgression,
genome‐wide
patterns
phylogenetic
discordance
predictably
with
different
histories
hybridisation.
Using
whole‐genome
sequencing
introgression
across
M.
radiation,
identify
signals
both
island
their
ancestors.
In
addition,
find
widespread
selection
against
introgressed
ancestry,
consistent
polygenic
barriers
flow.
However,
also
localised
genome
indicate
adaptive
introgression.
This
study
highlights
challenges
trying
disentangle
complex
More
broadly,
our
results
illustrate
roles
play
radiations:
expose
genetic
incompatibilities
contribute
while
likely
facilitating
adaptation
by
transferring
beneficial
alleles
taxa.
These
findings
underscore
dynamic
interplay
natural
shaping
trajectories
within
radiations.
Nature Communications,
Journal Year:
2022,
Volume and Issue:
13(1)
Published: Nov. 11, 2022
Abstract
Helicobacter
pylori
lives
in
the
human
stomach
and
has
a
population
structure
resembling
that
of
its
host.
However,
H.
from
Europe
Middle
East
trace
substantially
more
ancestry
modern
African
populations
than
humans
carry
them.
Here,
we
use
collection
Afro-Eurasian
genomes
to
show
this
is
due
at
least
three
distinct
admixture
events.
Asia,
which
have
undergone
little
admixture,
accumulated
many
non-synonymous
mutations
strains.
European
Eastern
bacteria
elevated
sites
these
mutations,
implying
selection
remove
them
during
admixture.
Simulations
fitness
can
be
restored
after
bottlenecks
by
migration
subsequent
small
numbers
non-bottlenecked
populations.
We
conclude
recent
spread
DNA
been
driven
deleterious
original
out-of-Africa
bottleneck.
