Comprehensive multi-omics profiling of a healthy human cohort DOI Creative Commons
Casper de Visser, Anna Niehues, Lukáš Najdekr

et al.

bioRxiv (Cold Spring Harbor Laboratory), Journal Year: 2024, Volume and Issue: unknown

Published: Nov. 11, 2024

ABSTRACT Multi-omics investigations hold promise for uncovering biomarker profiles crucial disease diagnosis, prognosis, and monitoring interventions. However, these are susceptible to technical biological variation. Capturing variability removing essential future studies. The EATRIS-Plus consortium analyzed blood samples from 127 healthy adults across twelve omics layers, resulting in one of the most comprehensive profiling datasets. These layers were integrated with reproducible workflows. Sex significantly impacted all profiles, highlighting need sex-balanced Age was associated fewer features, but we could accurately predict participants’ age epigenetic predictors( R 2 = 0.90). And identified aging biomarkers other layers. Strikingly, features including miR-877-5p, CDP-diacylglycerol, COQ10B , SH3GLB1 MFSD14A mRNAs immunoglobulin proteins (False Discovery Rate < 0.05) difference between chronological age, not itself. dataset is FAIR made accessible via ClinData Portal Zenodo repository. This reference normal ranges abundance variation can guide enables power analyses sample size estimations multi-omics studies ideal benchmarking computational methods that integrate data.

Language: Английский

Genome-Wide Identification of the Soybean AlkB Homologue Gene Family and Functional Characterization of GmALKBH10Bs as RNA m6A Demethylases and Expression Patterns under Abiotic Stress DOI Creative Commons
Jie Zhao,

Tengfeng Yang,

Peng Liu

et al.

Plants, Journal Year: 2024, Volume and Issue: 13(17), P. 2491 - 2491

Published: Sept. 5, 2024

Soybean (

Language: Английский

Citations

3
Omics big data for crop improvement: Opportunities and challenges DOI Creative Commons

Naresh Vasupalli,

Javaid Akhter Bhat, Priyanka Jain

et al.

The Crop Journal, Journal Year: 2024, Volume and Issue: unknown

Published: Nov. 1, 2024

Language: Английский

Citations

1
Comprehensive multi-omics profiling of a healthy human cohort DOI Creative Commons
Casper de Visser, Anna Niehues, Lukáš Najdekr

et al.

bioRxiv (Cold Spring Harbor Laboratory), Journal Year: 2024, Volume and Issue: unknown

Published: Nov. 11, 2024

ABSTRACT Multi-omics investigations hold promise for uncovering biomarker profiles crucial disease diagnosis, prognosis, and monitoring interventions. However, these are susceptible to technical biological variation. Capturing variability removing essential future studies. The EATRIS-Plus consortium analyzed blood samples from 127 healthy adults across twelve omics layers, resulting in one of the most comprehensive profiling datasets. These layers were integrated with reproducible workflows. Sex significantly impacted all profiles, highlighting need sex-balanced Age was associated fewer features, but we could accurately predict participants’ age epigenetic predictors( R 2 = 0.90). And identified aging biomarkers other layers. Strikingly, features including miR-877-5p, CDP-diacylglycerol, COQ10B , SH3GLB1 MFSD14A mRNAs immunoglobulin proteins (False Discovery Rate < 0.05) difference between chronological age, not itself. dataset is FAIR made accessible via ClinData Portal Zenodo repository. This reference normal ranges abundance variation can guide enables power analyses sample size estimations multi-omics studies ideal benchmarking computational methods that integrate data.

Language: Английский

Citations

0