Prevalent fast evolution of genes involved in heterochromatin functions DOI Creative Commons

Leila Lin,

Yuheng Huang, Jennifer McIntyre

et al.

Molecular Biology and Evolution, Journal Year: 2024, Volume and Issue: 41(9)

Published: Aug. 24, 2024

Heterochromatin is a gene-poor and repeat-rich genomic compartment universally found in eukaryotes. Despite its low transcriptional activity, heterochromatin plays important roles maintaining genome stability, organizing chromosomes, suppressing transposable elements. Given the importance of these functions, it expected that genes involved regulation would be highly conserved. Yet, handful were to evolve rapidly. To investigate whether previous findings are anecdotal or general modulating heterochromatin, we compile an exhaustive list 106 candidate functions their evolution over short long evolutionary time scales Drosophila. Our analyses find exhibit significantly more frequent changes, both forms amino acid substitutions gene copy number change, when compared Polycomb-based repressive chromatin. While positive selection drives changes within structured domains with diverse intrinsically disordered regions, purifying may have maintained proportions regions proteins. Together observed negative associations between rate abundance elements, propose model where fast inevitable outcome unique functional while rapid elements effect rather than cause. study provides global view this critical cellular domain insights into factors driving distinctive heterochromatin.

Language: Английский

Diversification and recurrent adaptation of the synaptonemal complex in Drosophila DOI Creative Commons

Rana Zakerzade,

Ching-Ho Chang, Kamalakar Chatla

et al.

PLoS Genetics, Journal Year: 2025, Volume and Issue: 21(1), P. e1011549 - e1011549

Published: Jan. 13, 2025

The synaptonemal complex (SC) is a protein-rich structure essential for meiotic recombination and faithful chromosome segregation. Acting like zipper to paired homologous chromosomes during early prophase I, the symmetrical where central elements are connected on two sides by transverse filaments chromatin-anchoring lateral elements. Despite being found in most major eukaryotic taxa implying deeply conserved evolutionary origin, several components of exhibit unusually high rates sequence turnover. This puzzlingly exemplified SC Drosophila , display no identifiable homologs outside genus. Here, we exhaustively examine history taking comparative phylogenomic approach with species density circumvent obscured homology due rapid evolution. Contrasting starkly against other genes involved pairing, show significantly elevated coding evolution combination relaxed constraint recurrent, widespread positive selection. In particular, element cona filament c(3) G have diversified through tandem retro-duplications, repeatedly generating paralogs novel germline activity. striking case molecular convergence, that independently arose distant lineages evolved under selection convergent truncations protein termini testes expression. Surprisingly, expression prone change suggesting recurrent regulatory which, many species, resulted even though males achiasmic. Overall, our study recapitulates poor conservation components, further uncovers lack extends modalities including copy number, genomic locale, regulation. Considering common ancestor, suggest activity male germline, while still poorly understood, may be prime target constant pressures driving repeated adaptations innovations.

Language: Английский

Citations

1
Prevalent fast evolution of genes involved in heterochromatin functions DOI Creative Commons

Leila Lin,

Yuheng Huang, Jennifer McIntyre

et al.

bioRxiv (Cold Spring Harbor Laboratory), Journal Year: 2024, Volume and Issue: unknown

Published: March 6, 2024

Heterochromatin is a gene-poor and repeat-rich genomic compartment universally found in eukaryotes. Despite its low transcriptional activity, heterochromatin plays important roles maintaining genome stability, organizing chromosomes, suppressing transposable elements (TEs). Given the importance of these functions, it expected that genes involved regulation would be highly conserved. Yet, handful were to evolve rapidly. To investigate whether previous findings are anecdotal or general modulating heterochromatin, we compile an exhaustive list 106 candidate functions their evolution over short long evolutionary time scales

Language: Английский

Citations

0
Prevalent fast evolution of genes involved in heterochromatin functions DOI Creative Commons

Leila Lin,

Yuheng Huang, Jennifer McIntyre

et al.

Molecular Biology and Evolution, Journal Year: 2024, Volume and Issue: 41(9)

Published: Aug. 24, 2024

Heterochromatin is a gene-poor and repeat-rich genomic compartment universally found in eukaryotes. Despite its low transcriptional activity, heterochromatin plays important roles maintaining genome stability, organizing chromosomes, suppressing transposable elements. Given the importance of these functions, it expected that genes involved regulation would be highly conserved. Yet, handful were to evolve rapidly. To investigate whether previous findings are anecdotal or general modulating heterochromatin, we compile an exhaustive list 106 candidate functions their evolution over short long evolutionary time scales Drosophila. Our analyses find exhibit significantly more frequent changes, both forms amino acid substitutions gene copy number change, when compared Polycomb-based repressive chromatin. While positive selection drives changes within structured domains with diverse intrinsically disordered regions, purifying may have maintained proportions regions proteins. Together observed negative associations between rate abundance elements, propose model where fast inevitable outcome unique functional while rapid elements effect rather than cause. study provides global view this critical cellular domain insights into factors driving distinctive heterochromatin.

Language: Английский

Citations

0