Genetic Causal Associations between Various Serum Minerals and Risk of Depression: A Mendelian Randomization Study DOI Open Access
Yuan Wang, Lini Liu, Dong Yang

et al.

Actas Españolas de Psiquiatría, Journal Year: 2024, Volume and Issue: 52(3), P. 211 - 220

Published: June 5, 2024

Background: Previous observational studies have discovered a connection between depression and mineral status. Confirming this potential is challenging due to confounding factors reverse causality which inherent in studies. Materials Methods: We performed Mendelian randomization (MR) analysis estimate the causal association of serum minerals with depression. Leveraging summary-level data on depression, genome-wide study (GWAS) was applied. The were collected from FinnGen Biobank database. MR assessments representing produced by inverse-variance weighted approaches multiplicative random fixed effects. Result: Sensitivity analyses validate reliability results. A noteworthy correlation emerged zinc levels reduced risk An odds ratio (OR) 0.917 for associated one standard deviation increase (OR = 0.968; 95% CI 0.953–0.984, p 1.19 × 10-4, effects model inverse variance (IVW)); 0.928; 0.634–1.358, 0.766, Egger). supported causation. However, did not exhibit an other minerals. Conclusions: In summary, higher concentration causally risk. This outcome may assist clinicians regulation specific intake, particularly high-risk patients deficiencies.

Language: Английский

Effects of Cadmium Pollution on Human Health: A Narrative Review DOI Creative Commons

Yunxi Yang,

Mohammad Farooque Hassan,

Waseem Ali

et al.

Atmosphere, Journal Year: 2025, Volume and Issue: 16(2), P. 225 - 225

Published: Feb. 17, 2025

Cadmium (Cd) is a pervasive environmental and industrial toxin that poses significant health risks. It readily moves through soil–plant systems, leading to global contamination human exposure diet, smoking, pollution. The main purpose of this review explore the effect Cd on physiological processes different bodies’ organs, including bones, kidneys, liver, as well immune, cerebrovascular, cardiovascular, reproductive systems. Accumulation in body can result poisoning with severe impacts bone kidney health, reduced mineral density due renal damage. Research has linked lung cancer pulmonary toxicity, elevated urinary biomarkers suggest compromised function. also affects immune systems; liver; contributing various diseases by disrupting blood pressure calcium regulation, causing oxidative stress DNA damage, impairing cell functions. Ongoing research essential fully understand Cd-induced toxicological effects develop effective interventions prevent mitigate

Language: Английский

Citations

3
Cadmium exposure induces inflammation, oxidative stress and DNA damage in HUVEC and promotes THP-1 adhesion: a possible mechanism on the formation of Atherosclerotic plaque DOI
Haotian Liu, Mingyang Fu,

Ziqi Ren

et al.

Toxicology, Journal Year: 2025, Volume and Issue: unknown, P. 154046 - 154046

Published: Jan. 1, 2025

Language: Английский

Citations

1
Zn2+ protects H9C2 cardiomyocytes by alleviating MAMs-associated apoptosis and calcium signaling dysregulation DOI

Jiabao Guo,

Tingting Ma,

Bingyu Wang

et al.

Cellular Signalling, Journal Year: 2025, Volume and Issue: unknown, P. 111629 - 111629

Published: Jan. 1, 2025

Language: Английский

Citations

0
The Neurobehavioral Impact of Zinc Chloride Exposure in Zebrafish: Evaluating Cognitive Deficits and Probiotic Modulation DOI Creative Commons
Mihaela Ene, Alexandra Săvucă,

Alin-Stelian Ciobica

et al.

Toxics, Journal Year: 2025, Volume and Issue: 13(3), P. 193 - 193

Published: March 8, 2025

Zinc contamination in aquatic environments has become a growing concern due to its potential bioaccumulate and induce neurotoxic effects organisms. As an essential trace element, zinc plays crucial role various physiological processes, but excessive exposure can disrupt the gut–brain axis, leading cognitive behavioral impairments. Recent studies have suggested that probiotics may offer protective against environmental neurotoxins by modulating gut microbiota associated neurological functions. The zebrafish (Danio rerio) emerged as valuable model organism for studying biological mechanisms underlying neurotoxicity therapeutic interventions. This study aimed assess of on impairments induced chloride (ZnCl2) zebrafish. Specifically, were exposed ZnCl2 at concentrations 0.5 mg/L 1.0 96 h, followed 7-day post-exposure period (Bifidobacterium longum, Bifidobacterium animalis lactis, Lactobacillus rhamnosus). these is already known neuromotor deficits resembling Alzheimer’s disease-like symptoms models, making it suitable evaluating neuroprotective probiotics. Behavioral assessments including sociability tests along with short- long-term memory evaluations conducted using EthoVision XT 16 software. Memory demonstrated impaired functions, while probiotic treatment did not significantly ameliorate deficits. In social behavior test, resulted marked decrease sociability, whereas significant changes. However, administration following intoxication exhibited anxiolytic effect These findings suggest exhibit partial neurobehavioral benefits chloride-induced toxicity, particularly mitigating anxiety-like behaviors rather than Further investigations are needed elucidate precise which interact axis context heavy metal neurotoxicity.

Language: Английский

Citations

0
ZnT6-mediated Zn2+ redistribution: impact on mitochondrial fission and autophagy in H9c2 cells DOI
Erkan Tuncay, Yusuf Olğar,

Leila Aryan

et al.

Molecular and Cellular Biochemistry, Journal Year: 2025, Volume and Issue: unknown

Published: March 14, 2025

Language: Английский

Citations

0
Genetic Causal Associations between Various Serum Minerals and Risk of Depression: A Mendelian Randomization Study DOI Open Access
Yuan Wang, Lini Liu, Dong Yang

et al.

Actas Españolas de Psiquiatría, Journal Year: 2024, Volume and Issue: 52(3), P. 211 - 220

Published: June 5, 2024

Background: Previous observational studies have discovered a connection between depression and mineral status. Confirming this potential is challenging due to confounding factors reverse causality which inherent in studies. Materials Methods: We performed Mendelian randomization (MR) analysis estimate the causal association of serum minerals with depression. Leveraging summary-level data on depression, genome-wide study (GWAS) was applied. The were collected from FinnGen Biobank database. MR assessments representing produced by inverse-variance weighted approaches multiplicative random fixed effects. Result: Sensitivity analyses validate reliability results. A noteworthy correlation emerged zinc levels reduced risk An odds ratio (OR) 0.917 for associated one standard deviation increase (OR = 0.968; 95% CI 0.953–0.984, p 1.19 × 10-4, effects model inverse variance (IVW)); 0.928; 0.634–1.358, 0.766, Egger). supported causation. However, did not exhibit an other minerals. Conclusions: In summary, higher concentration causally risk. This outcome may assist clinicians regulation specific intake, particularly high-risk patients deficiencies.

Language: Английский

Citations

0