Metal Dyshomeostasis as a Driver of Gut Pathology in Autism Spectrum Disorders

Journal of Neurochemistry, Journal Year: 2025, Volume and Issue: 169(3)

Published: March 1, 2025

ABSTRACT Despite being classified as neurodevelopmental disorders, in recent years, there has been a growing interest the association between autism spectrum disorders (ASDs) and gut pathology. This comprehensive systematic review explores potential mechanism underlying pathology ASDs, including alterations microbiota, intestinal permeability, immune dysregulation, gastrointestinal (GI) symptoms. Specifically, it delves into role of toxic essential metals their interplay, affecting development function GI tract. The also discusses implications this management ASDs. Studies have shown that heavy metal exposure, whether through environmental sources or dietary intake, can disrupt delicate balance trace elements gut. disruption adversely affect zinc homeostasis, potentially exacerbating individuals with impaired absorption resulting from exposure may contribute to oxidative stress, inflammation observed By shedding light on multifaceted nature pathology, impact dyshomeostasis non‐genetic factor ASD, underscores significance gut‐brain axis etiology image

Language: Английский

Dietary Fiber Intake Improves Osteoporosis Caused by Chronic Lead Exposure by Restoring the Gut–Bone Axis

Nutrients, Journal Year: 2025, Volume and Issue: 17(9), P. 1513 - 1513

Published: April 29, 2025

Background: Lead (Pb), a pervasive environmental toxicant with specific toxicity to bone, has been recognized as significant etiological factor in the pathogenesis of osteoporosis. While dietary fiber (DF) demonstrates anti-osteoporotic potential, its protective role against Pb-induced bone loss remains unexplored. Methods: This study analyzed association between fiber, blood lead, and osteoporosis based on NHANES database, validated it by constructing lead exposed mouse model. Micro CT was used evaluate microstructure, ELISA detect markers, q-PCR/Western blot measure intestinal tight junction protein, flow cytometry analyze Treg cells colon/bone tissue, GC-MS short chain fatty acids, 16S rRNA sequencing changes gut microbiota. The regulatory mechanism metabolism barrier mice systematically evaluated. Results: Based data analysis, found that can reduce risk populations. Animal experiments have shown intervention significantly increases density, improves microstructure metabolic indicators, repairs damage caused exposure, regulates immune balance mice. At same time, promotes generation acids proliferation beneficial Conclusions: These findings indicate DF mitigates through restoration, SCFA-mediated immunomodulation, microbiota-driven cell expansion along gut-bone axis.

Language: Английский