Genomic language models: opportunities and challenges

Trends in Genetics, Journal Year: 2025, Volume and Issue: unknown

Published: Jan. 1, 2025

Language: Английский

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A long-context language model for deciphering and generating bacteriophage genomes

Nature Communications, Journal Year: 2024, Volume and Issue: 15(1)

Published: Oct. 30, 2024

Inspired by the success of large language models (LLMs), we develop a long-context generative model for genomes. Our multiscale transformer model, megaDNA, is pre-trained on unannotated bacteriophage genomes with nucleotide-level tokenization. We demonstrate foundational capabilities our including prediction essential genes, genetic variant effects, regulatory element activity and taxonomy sequences. Furthermore, it generates de novo sequences up to 96 K base pairs, which contain potential elements annotated proteins phage-related functions.

Language: Английский

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ABI and generative biology: A new paradigm for gene therapy, genome engineering, and engineered cell therapy

Molecular Therapy, Journal Year: 2025, Volume and Issue: unknown

Published: March 1, 2025

Language: Английский

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