The impact of population ageing on the burden of chronic kidney disease

Nature Reviews Nephrology, Journal Year: 2024, Volume and Issue: 20(9), P. 569 - 585

Published: July 18, 2024

Language: Английский

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Pathogenesis of Sarcopenia in Chronic Kidney Disease—The Role of Inflammation, Metabolic Dysregulation, Gut Dysbiosis, and microRNA

International Journal of Molecular Sciences, Journal Year: 2024, Volume and Issue: 25(15), P. 8474 - 8474

Published: Aug. 3, 2024

Chronic kidney disease (CKD) is a progressive disorder associated with decline in function. Consequently, patients advanced stages of CKD require renal replacement therapies, such as dialysis and transplantation. Various conditions lead to the development CKD, including diabetes mellitus, hypertension, glomerulonephritis, among others. The metabolic hormonal dysregulation, uraemia hyperparathyroidism, well low-grade systemic inflammation. Altered homeostasis increases risk developing severe comorbidities, cardiovascular diseases or sarcopenia, which increase mortality. Sarcopenia defined muscle mass However, precise mechanisms that link sarcopenia are poorly understood. Knowledge about these linking might introduction treatment strategies could prevent wasting. This review discusses inflammatory mediators, gut microbiota dysbiosis, non-coding RNA alterations sarcopenia.

Language: Английский

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Young Plasma Attenuated Chronic Kidney Disease Progression after Acute Kidney Injury by Inhibiting Inflammation in Mice

Aging and Disease, Journal Year: 2024, Volume and Issue: unknown

Published: Jan. 1, 2024

In the aged patients suffering from acute kidney injury, risk for progression to chronic disease and mortality is high. Aging accompanied by glomerulosclerosis, interstitial inflammation, fibrosis might be one of underlying mechanisms vulnerability. addition sustained activation renin-angiotensin system, persistent inflammation with tertiary lymphoid tissue formation more common associated in after injury. Based on recent laboratory evidence that young blood can rejuvenate brain, muscle, heart, we were intrigued possible protective effect plasma injury mice. Here, demonstrated 2-month-old mice could attenuate 15-month-old subjected induced ischemia-reperfusion. administration decreased tubulointerstitial fibrosis, kidneys assessed day 28 despite no significant beneficial severity survival. Mechanistically, inhibited angiotensin II-activated chemokines pericytes responsible formation. summary, our data provide attenuates transition The therapeutic potential infusion or exchange needs addressed clinical trials.

Language: Английский

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Biomarkers of chronic kidney disease in older individuals: navigating complexity in diagnosis

Frontiers in Medicine, Journal Year: 2024, Volume and Issue: 11

Published: July 11, 2024

Chronic kidney disease (CKD) in older individuals is a matter of growing concern the field public health across globe. Indeed, prevalence function impairment increases with advancing age and often exacerbated by age-induced modifications function, presence chronic diseases such as diabetes, hypertension, cardiovascular disorders, increased burden related to frailty, cognitive sarcopenia. Accurate assessment CKD crucial for timely intervention management relies heavily on biomarkers diagnosis monitoring. However, interpretation these patients may be complex due interplays between CKD, aging, geriatric syndromes. Biomarkers serum creatinine, estimated glomerular filtration rate (eGFR), albuminuria can significantly altered systemic inflammation, metabolic changes, medication use commonly seen this population. To overcome limitations traditional biomarkers, several innovative proteins have been investigated potential, review we aimed at consolidating existing data concerning aspects describing challenges considerations using assess patients, highlighting need integration clinical context improve biomarkers’ accuracy.

Language: Английский

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Use of the BIOGROUP^® French laboratories database to conduct CKD observational studies: a pilot EPI-CKD1 study

Clinical Chemistry and Laboratory Medicine (CCLM), Journal Year: 2025, Volume and Issue: unknown

Published: March 18, 2025

Abstract Objectives Medical biology is essential for diagnosing and monitoring cardio-reno-metabolic diseases. The EPI-CKD1 study utilizes data from Biogroup ® French laboratories to examine the burden of chronic kidney disease (CKD) effect heart failure, diabetes in an outpatient setting order address gaps national databases that lack biological data. Methods All adults (≥18 years) with at least one blood creatinine test between January 1st 2021, June 30th 2022 were included. Key biomarkers measured included serum creatinine, estimated glomerular filtration rate (eGFR), hemoglobin A 1c , B-type natriuretic peptide (BNP), NT-Pro BNP, urinary albumin/creatinine ratio (uACR). Results Among a total 4,061,208 test, 465,225 (11.5 %) had altered function. Their mean age was 57.9 years (SD 18.8), 56.7 % women. Diabetes present 8.3 %, failure 1.4 %. Altered function standardized prevalence 8.06 incidence 5.10 Patients end-stage CKD average 7.9 eGFR measurements, compared 2 those >60 mL/min/1.73 m . Older age, diabetes, associated increased risk <60 Conclusions demonstrates utility large-scale observational studies, offering precise, medically relevant insights on patients cardio-renal risk. Future studies should focus enrichment long-term follow-up deepen understanding.

Language: Английский

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Impact of metabolic phenotype changes on the development of chronic kidney disease: Panasonic cohort study 17

Obesity, Journal Year: 2025, Volume and Issue: unknown

Published: April 23, 2025

Abstract Objective This study investigated how changes in metabolic phenotype, defined by obesity and health, impact chronic kidney disease (CKD) development a large cohort. Methods A retrospective cohort analyzed health data collected between 2011 2021 from 84,729 Panasonic Holdings Corporation (formerly Corporation) employees aged ≥40 years. Metabolic phenotypes were classified as metabolically healthy with no (MHNO), (MHO), abnormalities (MANO), (MAO). Changes phenotype over 3 years their association CKD assessed using Cox proportional hazards models adjusted for confounding variables. Results During mean follow‐up of 5.1 years, total 12,172 participants (14.4%) developed CKD. Transitioning MHO to MHNO MAO MANO did not reduce risk compared each stable group. In contrast, the MANO‐to‐MHNO MAO‐to‐MHO groups significantly lowered relative group, hazard ratios 0.86 (95% CI: 0.77–0.96) 0.83 0.67–1.02), respectively. The same results observed when rapid decline renal function was used outcome. Conclusions improvement profile might outweigh weight reduction risk.

Language: Английский

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Identification of potential anti aging drugs and targets in chronic kidney disease

Scientific Reports, Journal Year: 2025, Volume and Issue: 15(1)

Published: May 3, 2025

Language: Английский

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Proyección de la carga clínica y económica de la enfermedad renal crónica entre 2022 y 2027 en España: resultados del proyecto Inside CKD

Nefrología, Journal Year: 2024, Volume and Issue: 44(6), P. 807 - 817

Published: March 16, 2024

Antecedentes y objetivos: La enfermedad renal crónica (ERC) es un problema de salud creciente que afecta entre el 10% 15% la población española. escasez proyecciones actualizadas sobre evolución carga obstaculiza desarrollo políticas e intervenciones sanitarias basadas en evidencia para optimizar manejo prevenir su progresión. El objetivo este estudio proyectar clínica económica ERC España 2022 2027. Materiales métodos: Inside CKD utiliza enfoque microsimulación validado analizar proyectada ERC, a partir una hipotética según demografía española, bibliografía, registros datos nacionales opinión expertos clínicos. Los costes incluidos fueron asociados gestión tratamiento sustitutivo (TRS), las complicaciones cardiovasculares comorbilidades arteriales. Resultados: En España, se prevé incremento absoluto prevalencia del 1% (del 10,7% 11,7%) 2027, equivalente aumento 5,14 5,68 millones pacientes los cuales solo tercio serían diagnosticados. Se total 654.281 muertes acumuladas con diagnosticada 3,9% diagnosticados requerirán TRS 14,7% respecto 2022. aumente 13,8%, hasta 4.890 euros lo representaría 5,56% gasto sanitario público español 2027 (frente 4,88% 2022), 42,5% destinará (2,4% público). Conclusiones: proyecto demuestra clínica, social prevista progresión estadios más avanzados necesidad asociadas representan pequeña parte pero contribuyen forma significativa totales. Background and objective: Chronic kidney disease (CKD) is growing health problem affecting between of the Spanish population. The lack updated projections evolution burden hinders development evidence-based policies interventions to optimize management prevent its progression. aim this study project clinical economic in Spain Materials methods: uses validated microsimulation approach CKD. projection based on virtual population according demographics, literature, national data registries expert opinion. Costs associated with management, replacement therapy (RRT), cardiovascular complications arterial comorbidities were included. Results: In Spain, an absolute increase prevalence (from 10.7% 11.7%) expected corresponding from 5.14 million 5.68 patients However, only one third would be diagnosed. Of these diagnosed patients, 3.9% will require RRT 14.7% A 654,281 accumulated deaths are by 13.8% 4.89 billion representing 5.56% public expenditure (compared 4.88% which 42.5% allocated (2.4% expenditure). Conclusions: highlights clinical, Progression more advanced stages need for represent small proportion population, but contribute significantly overall costs.

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Accelerated Biological Aging , Genetic Predisposition, and Risk of Chronic Kidney Disease with Life Expectancy in Mid-Life: Results from a Prospective Cohort Study

Published: Jan. 1, 2024

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Language: Английский

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Assessment and Application of the Hear Score in Remote Emergency Medicine Outposts in Bosnia and Herzegovina

Medicina, Journal Year: 2024, Volume and Issue: 60(4), P. 657 - 657

Published: April 19, 2024

. In emergency departments, chest pain is a common concern, highlighting the critical importance of distinguishing between acute coronary syndrome and other potential causes. Our research aimed to introduce implement HEAR score, specifically, in remote outposts Bosnia Herzegovina.

Language: Английский

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