Understanding Treatment Preferences and Cognitive Outcomes in Patients with Gliomas DOI Creative Commons

Benjamin Sterling Succop,

Daniel R. Richardson,

Yasmeen Rauf

et al.

Research Square (Research Square), Journal Year: 2023, Volume and Issue: unknown

Published: Dec. 6, 2023

Abstract Objective: Understanding how glioma patients value specific cognitive outcomes is essential to personalizing their treatment plans. The purpose of this study was identify the modifiable functions most affected by and important patient quality life. Methods: Patients with gliomas were prospectively enrolled in focus groups individual interviews guided a standardized guide focused on functions. Patient values preferences elicited compared frequency reported deficits. NVivo natural language processing software used perform thematic analyses qualitative data. Results: Twenty participants participated, whom 60% female. Racial identification consisted 75% White, 15% Black/African American, 10% other. life cohort sense self (80% participants), memory (70% communication (25% participants). that experienced deficits because (65% concentration special senses (40% “Dealbreakers” complete loss independence, self, and/or ability interact loved ones. Conclusions: Glioma prioritized according intrinsic values, personal identity, For cohort, memory, highly valued patients. next phase will investigate relative survival these key using preference elicitation optimize surgical decision-making.

Language: Английский

Connectome imaging to facilitate preservation of the frontal aslant tract DOI
Harshal A. Shah,

Leonid Mittelman,

Souvik Singha

et al.

Clinical Neurology and Neurosurgery, Journal Year: 2025, Volume and Issue: 249, P. 108726 - 108726

Published: Jan. 5, 2025

Language: Английский

Citations

0
Enhancing Brain Tumor Surgery Precision with Multimodal Connectome Imaging: Structural and Functional Connectivity in Language-Dominant Areas DOI
Harshal A. Shah, James Duehr, Arevik Abramyan

et al.

Clinical Neurology and Neurosurgery, Journal Year: 2025, Volume and Issue: unknown, P. 108760 - 108760

Published: Jan. 1, 2025

Language: Английский

Citations

0
Augmented Reality in Cranial Surgery: Surgical Planning and Maximal Safety in Resection of Brain Tumors via Head-Mounted Fiber Tractography DOI
Muhammet Enes Gurses, Elif Gökalp, Jordan Spatz

et al.

Clinical Neurology and Neurosurgery, Journal Year: 2025, Volume and Issue: 251, P. 108820 - 108820

Published: March 3, 2025

Language: Английский

Citations

0
Augmented surgical decision-making for glioblastoma: integrating AI tools into education and practice DOI Creative Commons
Melike Mut, Miaomiao Zhang,

Ishita Gupta

et al.

Frontiers in Neurology, Journal Year: 2024, Volume and Issue: 15

Published: June 7, 2024

Surgical decision-making for glioblastoma poses significant challenges due to its complexity and variability. This study investigates the potential of artificial intelligence (AI) tools in improving “decision-making processes” surgery. A systematic review literature identified 10 relevant studies, primarily focused on predicting resectability surgery-related neurological outcomes. AI tools, especially rooted radiomics connectomics, exhibited promise resection extent through precise tumor segmentation tumor-network relationships. However, they demonstrated limited effectiveness postoperative dynamic less quantifiable nature patient-related factors. Recognizing these challenges, including datasets interpretability requirement medical applications, underscores need standardization, algorithm optimization, addressing variability model performance then further validation clinical settings. While holds potential, it currently does not possess capacity emulate nuanced process utilized by experienced neurosurgeons comprehensive approach

Language: Английский

Citations

3
Targeted therapies for Glioblastoma multiforme (GBM): State‐of‐the‐art and future prospects DOI
S. Satish,

Maithili Athavale,

Prashant S. Kharkar

et al.

Drug Development Research, Journal Year: 2024, Volume and Issue: 85(7)

Published: Nov. 1, 2024

Glioblastoma multiforme (GBM) remains one of the most aggressive and lethal forms brain cancer, characterized by rapid growth resistance to conventional therapies. The present review explores latest advancements in targeted therapies for GBM, emphasizing critical role blood-brain barrier (BBB), blood-brain-tumor barrier, tumor microenvironment, genetic mutations influencing treatment outcomes. impact key hallmarks example, chemoresistance, hypoxia, presence glioma stem cells on disease progression multidrug are discussed detail. major focus is innovative strategies aimed at overcoming these challenges, such as use monoclonal antibodies, small-molecule inhibitors, novel drug delivery systems designed enhance penetration across BBB. Additionally, potential immunotherapy, specifically immune checkpoint inhibitors vaccine-based approaches, improve patient prognosis was explored. Recent clinical trials preclinical studies reviewed provide a comprehensive overview current landscape future prospects GBM treatment. integration advanced computational models personalized medicine approaches also considered, aiming tailor individual profiles better efficacy. Overall, while significant progress has been made understanding targeting complex biology continued research innovation imperative develop more effective sustainable therapeutic options patients battling this formidable disease.

Language: Английский

Citations

3
Standardizing connectome-based brain tumor surgery through a network-based surgical nomenclature DOI
Nicholas B. Dadario, Michael E. Ivan, Michael E. Sughrue

et al.

Journal of Neuro-Oncology, Journal Year: 2023, Volume and Issue: 161(3), P. 657 - 659

Published: Jan. 31, 2023

Language: Английский

Citations

6
Development of an educational method to rethink and learn oncological brain surgery in an “a la carte” connectome-based perspective DOI
Pablo A. Valdés, Sam Ng, Joshua D. Bernstock

et al.

Acta Neurochirurgica, Journal Year: 2023, Volume and Issue: 165(9), P. 2489 - 2500

Published: May 18, 2023

Language: Английский

Citations

6
Connectomic insight into unique stroke patient recovery after rTMS treatment DOI Creative Commons
Rong Chen, Nicholas B. Dadario, Brennan Cook

et al.

Frontiers in Neurology, Journal Year: 2023, Volume and Issue: 14

Published: July 6, 2023

An improved understanding of the neuroplastic potential brain has allowed advancements in neuromodulatory treatments for acute stroke patients. However, there remains a poor individual differences treatment-induced recovery. Individualized information on connectivity disturbances may help predict treatment response and recovery phenotypes. We studied medical data 22 ischemic patients who received MRI scans started repetitive transcranial magnetic stimulation (rTMS) same day. The functional motor outcomes were assessed at admission day, 1 day after treatment, 30 days 90 using four validated standardized outcome scales. Each patient underwent detailed baseline analyses to identify structural disturbances. unsupervised machine learning (ML) agglomerative hierarchical clustering method was utilized group according four-time points phenotypes trajectory. Differences features examined between clusters. Patients median age 64, 50% female, had hospital length stay 9.5 days. A significant improvement all time demonstrated post three scales utilized. ML-based identified distinct clusters representing unique trajectories each scale. Quantitative found exist network subcortical structures which could explain these Barthel Index (BI) scale but not other This study demonstrates first feasibility individualized differentiating rTMS responses personalized connectomic approach be future better understand with treatment.

Language: Английский

Citations

6
Connectome-Based Neurosurgery in Primary Intra-Axial Neoplasms: Beyond the Traditional Modular Conception of Brain Architecture for the Preservation of Major Neurological Domains and Higher-Order Cognitive Functions DOI Creative Commons
Marcello Magnani, Arianna Rustici, Matteo Zoli

et al.

Life, Journal Year: 2024, Volume and Issue: 14(1), P. 136 - 136

Published: Jan. 18, 2024

Despite the therapeutical advancements in surgical treatment of primary intra-axial neoplasms, which determined both a significative improvement OS and QoL reduction incidence surgery-induced major neurological deficits, nowadays patients continue to manifest subtle post-operative neurocognitive impairments, preventing them from full reintegration back into social life workforce. The birth connectomics paved way for profound reappraisal traditional conception brain architecture, favour model based on large-scale structural functional interactions complex mosaic cortical areas organized fluid network interconnected by subcortical bundles. Thanks these advancements, neurosurgery is facing new era connectome-based resections, core principle still represented achievement an ideal onco-functional balance, but with closer eye whole-brain circuitry, constitutes foundations functions, be intended as motricity; language visuospatial function; higher-order cognitive functions such cognition, conation, emotion adaptive behaviour. Indeed, balance between radicality tumoral resection preservation, far possible, integrity local global networks stands mandatory goal fulfilled allow resume their previous make tailored gentler individual needs.

Language: Английский

Citations

1
What is the cognitive footprint of insular glioma? DOI
Noah Nichols, Bahie Ezzat, Allison C. Waters

et al.

Frontiers in Human Neuroscience, Journal Year: 2024, Volume and Issue: 18

Published: May 27, 2024

Cognitive impairment has a profound deleterious impact on long-term outcomes of glioma surgery. The human insula, deep cortical structure covered by the operculum, plays role in wide range cognitive functions including interceptive thoughts and salience processing. Both low-grade (LGG) high-grade gliomas (HGG) involve representing up to 25% LGG 10% HGG. Surgical series from past 30 years support primary cytoreductive surgery for insular patients; however, reported are often limited speech language function. breath recent neuroscience literature demonstrates that insula broader cognition interoceptive This article summarizes vast functional healthy highlighting how this knowledge can be leveraged improve care patients with gliomas.

Language: Английский

Citations

1