Recent Advances in Ionic Mechanisms in Pituitary Cells: Implications for Electrophysiological and Electropharmacological Research DOI Open Access
Sheng‐Nan Wu, Ya‐Jean Wang,

Zi-Han Gao

et al.

Journal of Clinical Medicine, Journal Year: 2025, Volume and Issue: 14(9), P. 3117 - 3117

Published: April 30, 2025

Pituitary cells are specialized located within the pituitary gland, a small, pea-sized gland situated at base of brain. Through use cellular electrophysiological techniques, electrical properties these have been revealed. This review paper aims to introduce ion currents that known be functionally expressed in cells. These include voltage-gated Na+ current (INa), erg-mediated K+ (IK(erg)), M-type (IK(M)), hyperpolarization-activated cation (Ih), and large-conductance Ca2+-activated (BKCa) channel. The biophysical characteristics respective were described. Additionally, we also provide explanations for effect various drugs or compounds on each currents. GH3-cell exposure GV-58 can increase magnitude INa with concurrent rise inactivation time constant current. presence esaxerenone, an antagonist aldosterone receptor, directly suppresses peak late INa. Risperidone, atypical antipsychotic agent, is effective suppressing IK(erg) amplitude directly, di(2-ethylhexyl)-phthalate suppressed IK(erg). Solifenacin kynurenic acid interact KM channel stimulate IK(M), while carisbamate cannabidiol inhibit Ih activated by sustained hyperpolarization. Moreover, either rufinamide QO-40 enhance activity single BKCa channels. To summarize, alterations native tumor influence their functional activity, particularly processes like stimulus-secretion coupling. effects small-molecule modulators, as demonstrated here, bear significance clinical, therapeutic, toxicological contexts.

Language: Английский

Recent Advances in Ionic Mechanisms in Pituitary Cells: Implications for Electrophysiological and Electropharmacological Research DOI Open Access
Sheng‐Nan Wu, Ya‐Jean Wang,

Zi-Han Gao

et al.

Journal of Clinical Medicine, Journal Year: 2025, Volume and Issue: 14(9), P. 3117 - 3117

Published: April 30, 2025

Pituitary cells are specialized located within the pituitary gland, a small, pea-sized gland situated at base of brain. Through use cellular electrophysiological techniques, electrical properties these have been revealed. This review paper aims to introduce ion currents that known be functionally expressed in cells. These include voltage-gated Na+ current (INa), erg-mediated K+ (IK(erg)), M-type (IK(M)), hyperpolarization-activated cation (Ih), and large-conductance Ca2+-activated (BKCa) channel. The biophysical characteristics respective were described. Additionally, we also provide explanations for effect various drugs or compounds on each currents. GH3-cell exposure GV-58 can increase magnitude INa with concurrent rise inactivation time constant current. presence esaxerenone, an antagonist aldosterone receptor, directly suppresses peak late INa. Risperidone, atypical antipsychotic agent, is effective suppressing IK(erg) amplitude directly, di(2-ethylhexyl)-phthalate suppressed IK(erg). Solifenacin kynurenic acid interact KM channel stimulate IK(M), while carisbamate cannabidiol inhibit Ih activated by sustained hyperpolarization. Moreover, either rufinamide QO-40 enhance activity single BKCa channels. To summarize, alterations native tumor influence their functional activity, particularly processes like stimulus-secretion coupling. effects small-molecule modulators, as demonstrated here, bear significance clinical, therapeutic, toxicological contexts.

Language: Английский

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