Preoperative subjective impairments in language and memory in brain tumor patients DOI Creative Commons

Lena Rybka,

Roel Jonkers,

Milena Burzlaff

et al.

Frontiers in Oncology, Journal Year: 2024, Volume and Issue: 14

Published: Oct. 29, 2024

Background Subjective reports can reveal relevant information regarding the nature of impairment brain tumor patients, unveiling potential gaps in current assessment practices. The co-occurrence language and memory impairments has been previously reported, albeit scarcely. aim this study is therefore to understand subjective complaints preoperative state patients its impact on Quality Life (QoL). Methods 31 (12 LGG, 19 HGG) underwent a semi-structured interview assess deficits, co-occurrences between dysfunction, changes QoL. Group subgroup analyses were conducted provide general grade specific data. Results 48.4% mentioned reading, writing, conversation. HGG group reported all three these (reading: 31.6%; writing: 21.1%; conversation: 26.3%), while LGG only described reading (25%) conversation (8.3%), although not statistically significant. All with co-occurring deficits be linked reduced QoL (48.4%). In an HGG, number was slightly higher (52.6%) than (41.7%). Conclusion Language co-occur dysfunction as perceived patients’ daily life. Patients see affecting their quality Further attention dedicated tasks seems necessary.

Language: Английский

Does Personality Influence the Quality of Life of Patients with Brain Tumors Treated with Radiotherapy? DOI Open Access

Agnieszka Pilarska,

Anna Pieczyńska, Krystyna Adamska

et al.

Cancers, Journal Year: 2025, Volume and Issue: 17(1), P. 131 - 131

Published: Jan. 3, 2025

Background: Understanding the role of personality traits in shaping treatment outcomes is crucial given multifaceted challenges posed by brain tumors and significant adverse impact radiotherapy (RT) on patients’ well-being. Purpose: This study aimed to provide insights into how affect psychosocial well-being quality life during RT patients with high-grade malignant tumors. Methods: Personality glioma were assessed using Eysenck Questionnaire-Revised (EPQ-R). Quality was analyzed EORTC questionnaires: Questionnaire-Core 30 (QLQ-C30) Brain Cancer Module (QLQ-BN20). Patients evaluated before RT, immediately after 6 weeks 3 months post-RT. Results: Neuroticism predicted emotional function only three Extraversion decreased global health status (third assessment), (second third assessments) but improved cognitive (first assessment) social assessment). The trait associated lying linked a better all domains except physical function. Anxiety lower tumor across at various stages treatment. Conclusions: advances our understanding aspects care highlighting influence quality-of-life RT. Identifying greater risk diminished based profiles allows healthcare professionals tailor interventions address specific needs, ultimately enhancing patient holistic oncological

Language: Английский

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Dynamics Analysis of Nonlinear Differential Equation Systems Applied to Low-Grade Gliomas and Their Treatment DOI Creative Commons

Felipe J. Carmona-Moreno,

A. Gallegos, J. J. Barba-Franco

et al.

Foundations, Journal Year: 2025, Volume and Issue: 5(1), P. 6 - 6

Published: Feb. 19, 2025

Low-grade gliomas are a group of brain tumors that mostly affect people in early adulthood. A glioma is tumor originates glial cells. They classified into four levels according to their level proliferation, with grades 1 and 2 called low-grade gliomas. In this research, we conduct an analysis focused on mathematical model emulates the behavior chemotherapy treatment based system nonlinear differential equations. An carried out absence treatment, resulting predictive solution for if it left untreated some reason. turn, stability equations find critical points treating glioma. addition, numerical results obtained, presenting state variables at each instant. Finally, simulations presented, varying moments initiation applied doses Temozolomide.

Language: Английский

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The urgent need to redefine quality of life in patients with low-grade glioma DOI Creative Commons
Hugues Duffau

ESMO rare cancers., Journal Year: 2025, Volume and Issue: unknown, P. 100003 - 100003

Published: Feb. 1, 2025

Language: Английский

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The impact of financial toxicity on quality of life for survivors of primary brain tumour DOI Creative Commons

Jasmine Luttrell,

Katarzyna Lion, Mark B. Pinkham

et al.

Journal of Cancer Survivorship, Journal Year: 2025, Volume and Issue: unknown

Published: April 24, 2025

Abstract Purpose Despite the well-known impacts of financial hardship on cancer survivors, toxicity experienced in context brain tumour has received little attention. This study examined factors related to toxicity, and associations between anxiety quality life (QoL) this population. Method Adults with primary were recruited from hospital community services as part a telehealth psychological intervention study. They completed telephone cognitive screener at pre-intervention, Comprehensive Score for Financial Toxicity-Functional Assessment Chronic Illness Therapy (COST-FACIT), Generalised Anxiety Disorder-7 (GAD-7) Functional Cancer Therapy-Brain (FACT-Br) 6-week post-intervention assessment. Results Sixty survivors (60% female; M age = 47.90, SD 14.47) participated. Most sample (57%) mild moderate toxicity. Individuals high-grade glioma reported significantly higher levels compared those benign tumour. Greater perceived symptoms, lower global status symptoms associated contributed significant unique variance QoL (4.2%), controlling covariates. partially mediated relationship (β 0.24, CI 0.03, 0.55). Conclusions Higher are type (high-grade glioma), status, greater anxiety. Brain more likely experience QoL, which may be symptoms. Implications burden is survivors. These findings highlight importance early screening access personalised advice support.

Language: Английский

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Barriers and facilitators to self-management in people living with a lower-grade glioma DOI Creative Commons
Ben Rimmer,

Michelle Balla,

Lizzie Dutton

et al.

Journal of Cancer Survivorship, Journal Year: 2024, Volume and Issue: unknown

Published: March 21, 2024

Self-management can have clinical and quality-of-life benefits. However, people with lower-grade gliomas (LGG) may face chronic tumour- and/or treatment-related symptoms impairments (e.g. cognitive deficits, seizures), which could influence their ability to self-manage. Our study aimed identify understand the barriers facilitators self-management in LGG. We conducted semi-structured interviews 28 LGG across United Kingdom, who had completed primary treatment. Sixteen participants were male, mean age was 50.4 years, time since diagnosis 8.7 years. Interviews audio-recorded transcribed. Following inductive open coding, we deductively mapped codes Schulman-Green et al.'s framework of factors influencing self-management, developed illness. Data suggested extensive support for all five categories ('Personal/lifestyle characteristics', 'Health status', 'Resources', 'Environmental 'Healthcare system'), encompassing 18 self-management. How experience many these appears somewhat distinct from other cancers; described multiple, often co-occurring, challenges, primarily knowledge acceptance incurable condition, impact seizures transport difficulties, access (in)formal support. Several on a continuum, example, sufficient facilitator, whereas lack thereof, barrier People distinctive experiences wide-ranging These findings will improve awareness potential challenges faced by around inform development interventions this population.

Language: Английский

Citations

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Life with a lower-grade glioma: How can neuro-oncologists advance its understanding and management? DOI
Amélie Darlix, Estelle Guerdoux-Ninot

Neuro-Oncology Practice, Journal Year: 2024, Volume and Issue: 11(3), P. 223 - 225

Published: May 10, 2024

Journal Article Life with a lower-grade glioma: How can neuro-oncologists advance its understanding and management? Get access Amélie Darlix, Darlix Institute of Functional Genomics, University Montpellier, CNRS, INSERM, FranceDepartment Medical Oncology, Montpellier Cancer Institute, France Corresponding Author: MD, PhD, Department 208 avenue des Apothicaires, 34298 cedex 5, ([email protected]). https://orcid.org/0000-0003-1384-1709 Search for other works by this author on: Oxford Academic Google Scholar Estelle Guerdoux Desbrest Epidemiology Public Health, FranceSupportive Palliative Care Department, Psycho-Oncology Unit, https://orcid.org/0000-0002-9608-0791 Neuro-Oncology Practice, Volume 11, Issue 3, June 2024, Pages 223–225, https://doi.org/10.1093/nop/npae031 Published: 10 May 2024 history Corrected typeset:

Language: Английский

Citations

1
Patient-reported outcomes in neuro-oncology DOI
Josien C C Scheepens, Martin Taphoorn, Johan A F Koekkoek

et al.

Current Opinion in Oncology, Journal Year: 2024, Volume and Issue: 36(6), P. 560 - 568

Published: July 10, 2024

To provide up-to-date evidence on patient-reported outcomes (PROs) in neuro-oncology, with a focus the core constructs of health-related quality life (HRQoL) and use PROs clinical trials practice.[Supplemental Digital Content: Video Abstract Neuro-Oncology.mov].

Language: Английский

Citations

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“It’s a delicate dance” How informal caregivers experience the role and responsibilities of supporting someone living with a lower-grade glioma DOI
Ben Rimmer,

Michelle Balla,

Lizzie Dutton

et al.

Neuro-Oncology Practice, Journal Year: 2024, Volume and Issue: unknown

Published: Oct. 14, 2024

People with lower-grade gliomas (LGG) often require long-term support a condition that causes substantial symptom burden and is likely to progress. Partners, family, friends become informal caregivers (IC), but the types of they provide, their experiences this, have not been well investigated. We aimed understand how ICs experience role responsibilities supporting people LGG. This descriptive qualitative study used semistructured interviews explore purposive sample across United Kingdom, who currently, or in past 5 years, support(ed) someone an Interviews were audio-recorded transcribed, inductive thematic analysis was conducted. Nineteen interviewed (mean age 54.6 years; males/14 females). While most participants spoke about "Being 'carer'," level care provided varied. Participants conveyed "Adjusting for cognitive difficulties," "Emotional protection," "Supporting participation daily life," "Healthcare advocacy." felt "abandoned" by healthcare services provide required themselves, reported "Balancing challenges caregiving," including conflict work/childcare. Issues around "Maintaining recipient's independence" interwoven throughout. LGG wide-ranging help manage consequences illness. Consideration ways fulfilling this role, particularly, balancing provision without inhibiting independence, could improve outcomes

Language: Английский

Citations

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Understanding supported self‐management for people living with a lower‐grade glioma: Implementation considerations through the lens of normalisation process theory DOI Creative Commons
Ben Rimmer, Tracy Finch,

Michelle Balla

et al.

Health Expectations, Journal Year: 2024, Volume and Issue: 27(3)

Published: May 11, 2024

Abstract Background Supported self‐management can improve clinical and psychosocial outcomes in people with cancer; the considerations required to implement support (SMS) for living a lower‐grade glioma (LGG)—who often have complex needs—are not known. We aimed identify understand these implementation through lens of normalisation process theory (NPT), from perspectives healthcare professionals (HCP) LGG. Methods conducted semistructured interviews HCPs who adults brain tumours ( n = 25; 12 different professions), LGG had completed primary treatment 28; male 16, mean age 54.6 years, time since diagnosis 8.7 years), across United Kingdom. Interviews were transcribed inductive open coding conducted, before deductively mapping constructs NPT. first mapped HCP data, then integrated data explore alignment experiences perspectives. Results generated supporting evidence all four NPT related subconstructs, namely: ‘Coherence’, ‘Cognitive participation’, ‘Collective action’ ‘Reflexive monitoring’. Data clearly demonstrated that effective SMS constitutes collective activity. Key included: ensuring awareness of, access to, support; building strong HCP‐support recipient relationships; careful inclusion close family friends. identified pertinent challenges, such as identifying needs (influenced by extent which those engage help‐seeking), resistance (e.g., technology literacy), training cooperation. Conclusions This study demonstrates nature provides insight into individual roles within, supported self‐management. outline operationalise, sustain appraise Patient or Public Contribution People tumours, informal caregivers, involved development information materials topic guides ensure accessibility pertinence. They also opportunities comment on interview findings.

Language: Английский

Citations

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Glioma resource outreach with support: A program to identify and initiate supportive care interventions for unmet needs among adult lower-grade glioma patients DOI

Rachel Garcia Fox,

Ugonma Chukwueke, Timothy S. Sannes

et al.

Neuro-Oncology Practice, Journal Year: 2024, Volume and Issue: 12(1), P. 87 - 99

Published: Aug. 3, 2024

Abstract Background Lower-grade (WHO grades 2–3) gliomas typically affect young and middle-aged adults exhibit isocitrate dehydrogenase (IDH) mutations. For such patients, symptoms related to the tumor associated treatment contribute morbidity erode quality of life. With improved treatment, a better understanding these effects over time is critically needed. Existing data characterizing unmet needs lower-grade glioma patients limited little consensus exists on addressing in clinical practice. Methods In order identify address focus groups among caregivers were initially conducted treated at single academic center. A semi-structured interview guide comprehensively understand was then developed. Each patient-defined need categorized into domains through qualitative content analysis. parallel, database established local regional community-based resources established, dedicated resource specialist provided patient-specific referrals follow-up. Results Eighty-five interviewed. Median age 41 years median from diagnosis 63 months. Approximately 68% had WHO grade 2 60% off therapy. Qualitative analysis identified 5 overarching need: Psychosocial; Neurologic/Cognitive; Lifestyle; Financial; Other Medical. At least one by 71% participants most common Psychosocial (40.7%) Lifestyle (34.9%). Conclusions Our program begins frequently survivorship that spanned major domains. Further research aimed define warranted.

Language: Английский

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