Chemical Science, Journal Year: 2024, Volume and Issue: unknown
Published: Dec. 23, 2024
Solvent-derived peroxyl radicals (R sol OO·), a new group of reactive oxygen species (ROS), enable the radiation-induced aerobic oxidation strategy.
Language: Английский
Pharmaceutics, Journal Year: 2025, Volume and Issue: 17(2), P. 225 - 225
Published: Feb. 10, 2025
Metal–organic frameworks (MOFs) are a class of inorganic-organic hybrid nanoparticles formed by the coordination metal ions/clusters and organic ligands. Due to their high porosities, large surface areas, adjustable structures, responsiveness light/sound, etc., MOFs have shown great clinical potential in field tumor therapy. Tumor immunotherapy exerts antitumor effects through reshaping immune microenvironment, showing significant preclinical advantages. Based on mechanisms immunity activation, agents can be divided into chemotherapeutic agents, immunomodulators, enzymes, vaccines oligonucleotide drugs, etc. Herein, we review MOFs-based drug delivery systems for immunotherapy. The classification MOFs, followed activation mechanisms, first introduced. Drug based with different also summarized, especially synergetic triggered loadings. Furthermore, merits drawbacks strategies promote applications discussed.
Language: Английский
Citations
1
Journal of the American Chemical Society, Journal Year: 2024, Volume and Issue: unknown
Published: Nov. 20, 2024
Concurrent localized radiotherapy and systemic chemotherapy are standards of care for many cancers, but these treatment regimens cause severe adverse effects in patients. Herein, we report the design a mixed-ligand nanoscale metal–organic framework (nMOF) with ability to simultaneously enhance radiotherapeutic trigger release potent chemotherapeutic under X-ray irradiation. We synthesized new functional quaterphenyl dicarboxylate ligand conjugated SN38 (H2QP-SN) via hydroxyl radical-responsive covalent linkage. Because similar length QP-SN bis(p-benzoato)porphyrin (DBP) ligands, was incorporated into Hf-DBP nMOF afford novel multifunctional Hf-DBP-QP-SN good biocompatibility. not only enhances radiation damage tumors unique radiotherapy-radiodynamic therapy (RT-RDT) process also increases ·OH generation from radiolysis electron-dense Hf12 secondary building units (SBUs) chemotherapy. Elevated levels hydrogen peroxide tumor microenvironment further stimulate by enhancing With low doses irradiation, suppressed growth CT26 colon 4T1 breast 93.5% 95.2%, respectively, without any sign general toxicity. Our study highlights potential using ionizing radiation-mediated chemistry on-demand activation nanotherapeutics synergistic causing effects.
Language: Английский
Citations
4
Naunyn-Schmiedeberg s Archives of Pharmacology, Journal Year: 2025, Volume and Issue: unknown
Published: Feb. 5, 2025
Language: Английский
Citations
0
ACS Omega, Journal Year: 2025, Volume and Issue: unknown
Published: March 17, 2025
Immunotherapy is a critical modality in cancer treatment with diverse activation pathways. In recent years, the stimulator of interferon genes (STING) signaling pathway has exhibited significant potential tumor immunotherapy. This exerts notable antitumor effects by activating innate and adaptive immunity regulating immune microenvironment. Various metal ions have been identified as effective activators STING and, through design synthesis nanodelivery platforms, applied immunotherapy well combination therapies, such chemotherapy, chemodynamic therapy, photodynamic vaccines. Metal nanomaterials showcase unique advantages immunotherapy; however, there are still aspects that require optimization. review systematically examines existing metal-based nanomaterials, elaborates on mechanisms which different activate pathway, discusses their application models therapies. We also provide comparative analysis over other methods. Our exploration highlights broad prospects treatment, offering new insights directions for advancement
Language: Английский
Citations
0
Frontiers in Cell and Developmental Biology, Journal Year: 2025, Volume and Issue: 13
Published: April 28, 2025
Tumor metabolism plays a pivotal role in shaping immune responses within the tumor microenvironment influencing progression, evasion, and efficacy of cancer therapies. Radiotherapy has been shown to impact both modulation, often inducing activation through damage-associated molecular patterns STING pathway. In this study, we analyse particular characteristics tumour metabolic its effect on microenvironment. We also review changes that are induced by radiotherapy, with focus sensitisation effects radiotherapy. Our aim is contribute development research ideas field radiotherapy metabolic-immunological studies.
Language: Английский
Citations
0
Advanced Functional Materials, Journal Year: 2025, Volume and Issue: unknown
Published: May 24, 2025
Abstract Colorectal cancer (CRC) poses a significant threat to global public health, and immunotherapy has emerged as promising alternative its treatment. Nevertheless, owing the tumor immunosuppressive microenvironment (TIME), efficacy of single‐agent remains limited. Herein, CSZ@Gel is designed by co‐loading cyclic diguanosine (CDG) siXkr8 in zeolitic imidazolate framework‐8 (ZIF‐8) nanoparticles subsequently integrating them into α‐tocopherol polyethylene glycol succinate (TPGS) hydrogels. ZIF‐8 found undergo degradation under acidic conditions releasing cargo Zn 2+ induce cell pyroptosis. CDG triggers activation stimulator interferon genes (STING) pathway, leading enhanced release proinflammatory cytokines release, dendritic (DC) maturation CD8 + T infiltration. inhibits expression scramblase mXkr8 decreases phosphatidylserine translocation surface, thus decreasing immature DCs regulatory cells (Tregs) reversing TIME. In murine CRC model, exhibits growth suppression effects, extends median survival time mice more than 60 days, significantly recurrence after resection long‐term synergistic anti‐tumor immune activation. These findings suggest that provides an innovative drug delivery platform with clinical translation potential through comprehensive strategies for sustained immunotherapy.
Language: Английский
Citations
0
Angewandte Chemie, Journal Year: 2024, Volume and Issue: unknown
Published: Sept. 21, 2024
Abstract Pyroptosis, an inflammatory modality of programmed cell death associated with the immune response, can be initiated by bioactive ions and reactive oxygen species (ROS). However, ion‐induced pyroptosis lacks specificity, further exploration other that induce in cancer cells is needed. Sonocatalytic therapy (SCT) holds promise due to its exceptional penetration depth; however, rapid recombination electron‐hole (e − ‐h + ) pairs complex tumor microenvironment (TME) impede broader application. Herein, we discovered antimony (Sb)‐based nanomaterials induced cells. Therefore, Schottky heterojunctions containing Sb component (Sb 2 Se 3 @Pt) were effectively designed constructed via situ growth platinum (Pt) nanoparticles (NPs) on semiconductor narrow band gaps, which utilized as US‐heightened initiators highly effective boost SCT‐immunotherapy. Under US irradiation, excited electrons transferred from nanorods (NRs) co‐catalyst Pt junctions, bending prevented electron backflow achieved efficient ROS generation. Moreover, pores oxidized depleted overexpressed GSH TME, potentially amplifying The biological effects @Pt nanoheterojunction itself combined sonocatalytic amplification oxidative stress significantly Caspase‐1/GSDMD‐dependent SCT treatment not only restrained proliferation but also potent memory responses suppressed recurrence. Furthermore, integration this innovative strategy checkpoint blockade (ICB) elicited a systemic augmenting therapeutic impeding abscopal tumors. Overall, study provides opportunities explore pyroptosis‐mediated
Language: Английский
Citations
2
Angewandte Chemie International Edition, Journal Year: 2024, Volume and Issue: unknown
Published: Oct. 8, 2024
Abstract The activation of the stimulator interferon genes (STING) protein by cyclic dinucleotide metabolites plays a critical role in antitumor immunity. However, synthetic STING agonists like 4‐(5,6‐dimethoxybenzo[b]thiophen‐2‐yl)‐4‐oxobutanoic acid (MSA‐2) exhibit suboptimal pharmacokinetics and fail to sustain tumors for effective responses. Here, we report design MOF/MSA‐2, bifunctional MSA‐2 conjugated nanoscale metal–organic framework (MOF) based on Hf 6 secondary building units (SBUs) hexakis(4′‐carboxy[1,1′‐biphenyl]‐4‐yl)benzene bridging ligands, potent cancer radio‐immunotherapy. By leveraging high‐Z properties SBUs, MOF enhances therapeutic effect X‐ray radiation elicits immune stimulation tumor microenvironment. MOF/MSA‐2 further radiotherapeutic effects X‐rays enabling sustained promoting infiltration cells tumors. plus low‐dose irradiation strong regression, when combined with an checkpoint inhibitor, effectively suppresses both primary distant through systemic activation.
Language: Английский
Citations
1
Angewandte Chemie, Journal Year: 2024, Volume and Issue: unknown
Published: Oct. 8, 2024
Abstract The activation of the stimulator interferon genes (STING) protein by cyclic dinucleotide metabolites plays a critical role in antitumor immunity. However, synthetic STING agonists like 4‐(5,6‐dimethoxybenzo[b]thiophen‐2‐yl)‐4‐oxobutanoic acid (MSA‐2) exhibit suboptimal pharmacokinetics and fail to sustain tumors for effective responses. Here, we report design MOF/MSA‐2, bifunctional MSA‐2 conjugated nanoscale metal–organic framework (MOF) based on Hf 6 secondary building units (SBUs) hexakis(4′‐carboxy[1,1′‐biphenyl]‐4‐yl)benzene bridging ligands, potent cancer radio‐immunotherapy. By leveraging high‐Z properties SBUs, MOF enhances therapeutic effect X‐ray radiation elicits immune stimulation tumor microenvironment. MOF/MSA‐2 further radiotherapeutic effects X‐rays enabling sustained promoting infiltration cells tumors. plus low‐dose irradiation strong regression, when combined with an checkpoint inhibitor, effectively suppresses both primary distant through systemic activation.
Language: Английский
Citations
0
Chemical Science, Journal Year: 2024, Volume and Issue: unknown
Published: Dec. 23, 2024
Solvent-derived peroxyl radicals (R sol OO·), a new group of reactive oxygen species (ROS), enable the radiation-induced aerobic oxidation strategy.
Language: Английский
Citations
0