Impact of Olive Oil Components on the Expression of Genes Related to Type 2 Diabetes Mellitus DOI Open Access
Camelia Munteanu, Polina D. Kotova, Betty Schwartz

et al.

Nutrients, Journal Year: 2025, Volume and Issue: 17(3), P. 570 - 570

Published: Feb. 3, 2025

Type 2 diabetes mellitus (T2DM) is a multifactorial metabolic disorder characterized by insulin resistance and beta cell dysfunction, resulting in hyperglycemia. Olive oil, cornerstone of the Mediterranean diet, has attracted considerable attention due to its potential health benefits, including reducing risk developing T2DM. This literature review aims critically examine synthesize existing research regarding impact olive oil on expression genes relevant paper also seeks provide an immunological genetic perspective signaling pathways main components extra virgin oil. Key bioactive such as oleic acid phenolic compounds, were identified modulators signaling. These compounds enhanced pathway, improved lipid metabolism, reduced oxidative stress decreasing reactive oxygen species (ROS) production. Additionally, they shown alleviate inflammation inhibiting NF-κB pathway downregulating pro-inflammatory cytokines enzymes. Furthermore, these observed mitigate endoplasmic reticulum (ER) markers, thereby protecting cells from apoptosis preserving their function. In summary, particularly constituents, been demonstrated enhance sensitivity, protect function, reduce modulating key involved processes. findings underscore oil’s therapeutic managing However, further research, well-designed human clinical trials, required fully elucidate role personalized nutrition strategies for prevention treatment

Language: Английский

Impact of Olive Oil Components on the Expression of Genes Related to Type 2 Diabetes Mellitus DOI Open Access
Camelia Munteanu, Polina D. Kotova, Betty Schwartz

et al.

Nutrients, Journal Year: 2025, Volume and Issue: 17(3), P. 570 - 570

Published: Feb. 3, 2025

Type 2 diabetes mellitus (T2DM) is a multifactorial metabolic disorder characterized by insulin resistance and beta cell dysfunction, resulting in hyperglycemia. Olive oil, cornerstone of the Mediterranean diet, has attracted considerable attention due to its potential health benefits, including reducing risk developing T2DM. This literature review aims critically examine synthesize existing research regarding impact olive oil on expression genes relevant paper also seeks provide an immunological genetic perspective signaling pathways main components extra virgin oil. Key bioactive such as oleic acid phenolic compounds, were identified modulators signaling. These compounds enhanced pathway, improved lipid metabolism, reduced oxidative stress decreasing reactive oxygen species (ROS) production. Additionally, they shown alleviate inflammation inhibiting NF-κB pathway downregulating pro-inflammatory cytokines enzymes. Furthermore, these observed mitigate endoplasmic reticulum (ER) markers, thereby protecting cells from apoptosis preserving their function. In summary, particularly constituents, been demonstrated enhance sensitivity, protect function, reduce modulating key involved processes. findings underscore oil’s therapeutic managing However, further research, well-designed human clinical trials, required fully elucidate role personalized nutrition strategies for prevention treatment

Language: Английский

Citations

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