Microbiological and Epidemiological Aspects of Endocarditis Caused by Rothia spp.: A Systematic Review DOI Open Access
Antônio Neres Norberg, Paulo Roberto Blanco Moreira Norberg, Fernanda Castro Manhães

et al.

Journal of Advances in Medicine and Medical Research, Journal Year: 2023, Volume and Issue: 35(24), P. 100 - 127

Published: Dec. 20, 2023

Background and Aim: Rothia, a genus comprising pleomorphic Gram-positive bacteria found in the human oral, intestinal, skin microbiota, is recognized as an opportunistic pathogen. Case reports of Rothia spp. endocarditis scientific literature are scarce, with limited knowledge relevant data on clinical aspects its treatment. The objective this review to compile caused by species, analyzing results practices elucidate most important risk factors, comorbidities, prognostic appropriate antibiotic treatment options. Methods: Employing PRISMA model, systematic was conducted utilizing PubMed, SciELO, Google Scholar databases, encompassing articles published from 1978 November 2023. Pertinent were systematically recorded summarized for subsequent analysis. Results: dentocariosa (48.69%), mucilaginosa (22.37%), aeria (14.47%), kristinae (14.47%) agents cases. Patients exhibited average age 48.5 years, notable male preponderance (71.6%). Clinical manifestations presented similar features compared other bacterial mortality rate notably lower than observed infectious instances (11.84%). Predominant factors included preexisting cardiovascular diseases (50%), followed odontological procedures, caries, precarious oral hygiene (17.1%), immunocompromised status injectable illicit drug use (11.84%), diabetes (9.21%). Embolic events documented 35.53% patients, predominantly Central Nervous System (28.95%). Mycotic aneurysms identified 6.58% Resistance antibiotics only 13.16% strains causing endocarditis, although certain displayed characteristics indicative multidrug resistance. Conclusion: Despite rarity, exhibits parallels bacteria, but comparatively rate. Challenges identifying species based cultural microscopic characteristics, associated early resolution therapy, seems contribute underreporting these bacteria.

Language: Английский

Rifampicin in Staphylococcal Implant Infections: Precision Use or Pitfall? DOI Creative Commons
S Musumeci, Stefano Giulieri, Truong‐Thanh Pham

et al.

CMI Communications, Journal Year: 2025, Volume and Issue: unknown, P. 105085 - 105085

Published: May 1, 2025

Language: Английский

Citations

0
Endocarditis: A Review of Recent Literature DOI Creative Commons

Scott Dale,

Zaid Tayyem,

Steven Maceyko

et al.

Current Emergency and Hospital Medicine Reports, Journal Year: 2024, Volume and Issue: 12(2), P. 67 - 73

Published: April 22, 2024

Abstract Purpose of Review Endocarditis remains a challenging diagnosis, with significant implications for early identification and initiation therapy. In this review, we examine the evolution in epidemiology presentation infectious endocarditis (IE), role new diagnostic tools, approach to Recent Findings Staphylococcus Streptococcus species remain most common causative organisms, but prevalence IE caused by enterococcus non-HACEK organisms is increasing. While newer antibiotics such as dalbavancin have shown promise, treatment must still be tailored on an individual basis. Evidence suggests that antibiotic prophylaxis prevent limited high-risk patients undergoing invasive procedures. Summary The Duke Criteria, first established 1994, provide guideline which clinicians can identify affected patients. Now, 23 years after their last update 2000, Modified Criteria been revised account changes our understanding disease. When combined evolving guidelines, updated tools help combat

Language: Английский

Citations

3
Targeted Therapy of Severe Infections Caused by Staphylococcus aureus in Critically Ill Adult Patients: A Multidisciplinary Proposal of Therapeutic Algorithms Based on Real-World Evidence DOI Creative Commons
Milo Gatti, Bruno Viaggi, Gian María Rossolini

et al.

Microorganisms, Journal Year: 2023, Volume and Issue: 11(2), P. 394 - 394

Published: Feb. 3, 2023

(1) Introduction: To develop evidence-based algorithms for targeted antibiotic therapy of infections caused by Staphylococcus aureus in critically ill adult patients. (2) Methods: A multidisciplinary team four experts had several rounds assessment developing concerning antimicrobial severe The literature search was performed a researcher on PubMed-MEDLINE (until August 2022) to provide evidence supporting therapeutic choices. Quality and strength established according hierarchical scale the study design. Two different were created, one methicillin-susceptible (MSSA) other methicillin-resistant (MRSA). options categorized each site infection selected also basis pharmacokinetic/pharmacodynamic features. (3) Results: Cefazolin or oxacillin agents proposed all types MSSA infections. therapies MRSA site: daptomycin plus fosfomycin ceftaroline ceftobiprole bloodstream infections, infective endocarditis, and/or associated with intracardiac/intravascular devices; community-acquired pneumonia; linezolid alone infection-related ventilator-associated complications central nervous system infections; clindamycin necrotizing skin soft tissue (4) Conclusions: We are confident that based scientific optimization features monotherapy combo may represent valuable strategies treating

Language: Английский

Citations

8
Heartbreaking Decisions: The Dogma and Uncertainties of Antimicrobial Therapy in Infective Endocarditis DOI Creative Commons
Jennifer L. Adema, Aileen Ahiskali, Madiha Fida

et al.

Pathogens, Journal Year: 2023, Volume and Issue: 12(5), P. 703 - 703

Published: May 12, 2023

Infective endocarditis (IE) is a rare but increasingly prevalent disease with high morbidity and mortality, requiring antimicrobials at times surgical intervention. Through the decades of healthcare professionals’ experience managing IE, certain dogmas uncertainties have arisen around its pharmacotherapy. The introduction new novel combinations are exciting developments also further complicate IE treatment choices. In this review, we provide evaluate relevant evidence focused contemporary debates in pharmacotherapy, including beta-lactam choice MSSA combination therapies (aminoglycosides, ceftaroline), use oral antimicrobials, role rifamycins, long-acting lipoglycopeptides.

Language: Английский

Citations

4
Treatment of Complicated Gram-Positive Bacteremia and Infective Endocarditis DOI Creative Commons
Paul Schellong, Oana Joean, Mathias W. Pletz

et al.

Drugs, Journal Year: 2024, Volume and Issue: unknown

Published: Dec. 25, 2024

The Gram-positive cocci Staphylococcus aureus, Streptococcus spp., and Enterococcus spp. are the most frequent causative organisms of bloodstream infections infective endocarditis. "Complicated bacteremia" is a term used in S. aureus originally implied presence metastatic infectious foci (i.e. complications bacteremia). These demand longer antimicrobial treatment durations and, frequently, interventional source control. Several risk factors for incidence bacteremia have been identified often definition complicated bacteremia. Here, we discuss management diagnostic approaches options patients with bacteremia, particular focus on We also summarize available evidence regarding imaging modalities choice mono- or combination therapy according to resistance patterns these pathogens as well optimized application routes. Finally, synopsize current future areas research

Language: Английский

Citations

1
Effectiveness of adjunctive rifampicin for treatment of Staphylococcus aureus bacteraemia: a systematic review and meta-analysis of randomized controlled trials DOI
Ravindra Dotel, Gwendolyn L. Gilbert,

Sonya Natasha Hutabarat

et al.

Journal of Antimicrobial Chemotherapy, Journal Year: 2023, Volume and Issue: 78(10), P. 2419 - 2427

Published: July 1, 2023

Abstract Objectives To assess whether the addition of rifampicin to conventional treatment Staphylococcus aureus bacteraemia (SAB) reduces bacteriological or clinical failure death. Data Sources PubMed, Embase and Cochrane CENTRAL databases were searched from inception 31 December 2022. Reference lists PubMed citations eligible studies checked. Review methods Two study authors independently identified randomized controlled trials (RCTs) involving adult participants with SAB, in which an intervention group received adjunctive control usual care without a placebo. Dichotomous data (bacteriological deaths) analysed pooled across using risk ratio (RR) 95% confidence intervals (CI) Mantel-Haenszel random-effect model. The key variable interest being was used. Results Six RCTs including 894 participants—of 758 (85%) one trial—met inclusion criteria. SAB significantly reduced by 59% (RR 0.41, CI 0.21–0.81, I2 = 0%, number need treat 27). However, it did not reduce 0.70, 0.47–1.03, 0%) deaths 0.96, 0.70–1.32, 0%). Further, duration bacteraemia, length hospital stay. Adjunctive recurrences (1% versus 4%, P 0.01). Emergence resistance during uncommon (<1%). Conclusion Although recurrences, we found no mortality benefit support its use SAB.

Language: Английский

Citations

1
Should Rifampin Be Used to Treat Staphylococcal Prosthetic Valve Endocarditis? DOI
Dan Ilges,

Jamilah Shubeilat,

Sandhya Nagarakanti

et al.

Mayo Clinic Proceedings, Journal Year: 2024, Volume and Issue: 99(7), P. 1032 - 1034

Published: July 1, 2024

Language: Английский

Citations

0
Association between adjunctive rifampin and gentamicin use and outcomes for patients with staphylococcal prosthetic valve endocarditis: a propensity-score adjusted retrospective cohort study DOI
Hiroyuki Suzuki,

Abhishek Pandya,

Shinya Hasegawa

et al.

Infection, Journal Year: 2024, Volume and Issue: unknown

Published: Oct. 23, 2024

Language: Английский

Citations

0
Combination Therapy Is Not Associated with Decreased Mortality in Infectious Endocarditis: A Systematic Review and Meta-Analysis DOI Creative Commons
Parisa Farahani, Felicia Ruffin, Mohammad Taherahmadi

et al.

Microorganisms, Journal Year: 2024, Volume and Issue: 12(11), P. 2226 - 2226

Published: Nov. 2, 2024

Untreated infective endocarditis (IE) is uniformly fatal. The practice of combination antibiotic therapy for IE recommended by treatment guidelines but largely unsupported high-quality evidence. This study aimed to assess the efficacy compared monotherapy in through a systematic review and meta-analysis. We systematically searched MEDLINE, Embase, Cochrane, Web Science, CINAHL from inception 29 July 2024. Studies reporting mortality outcomes versus adult patients with were included. Non-English papers studies less than 10 group excluded. Two reviewers independently assessed extracted relevant data. Summaries odds ratios (ORs) 95% confidence intervals (CIs) evaluated using random-effects models. Out 4545 identified, 32 (involving 2761 patients) met inclusion criteria There was no significant difference risk all-cause between groups (OR = 0.90; CI 0.67-1.20). Similar results observed subgroup analyses based on time points, bacterial species, publication date, type study. conducted Europe reported statistically decrease overall 0.67; 0.51-0.89), though this result driven entirely single outlier Combination not associated reduced mortality.

Language: Английский

Citations

0
Antibiotic therapy and prophylaxis of infective endocarditis – A SPILF-AEPEI position statement on the ESC 2023 guidelines DOI Creative Commons

Vincent Le Moing,

É. Bonnet, Vincent Cattoir

et al.

Infectious Diseases Now, Journal Year: 2024, Volume and Issue: 55(1), P. 105011 - 105011

Published: Nov. 17, 2024

ou non, émanant des établissements d'enseignement et de recherche français étrangers, laboratoires publics privés.

Citations

0