Research progress of femoral head necrosis in HIV-infected patients

Annals of Medicine, Journal Year: 2025, Volume and Issue: 57(1)

Published: Jan. 23, 2025

As life expectancy among patients infected with the human immunodeficiency virus (HIV) increases, a growing number of complications have been observed. This population displays an elevated risk ischemic necrosis femoral head in comparison to general population, which may be attributed HIV infection, antiretroviral medication use, and hormone application. Patients who also tend present at earlier age, rapid disease progression high incidence bilateral onset. Magnetic resonance imaging (MRI) facilitates early diagnosis condition, recommended treatment is total hip arthroplasty. Currently, most prevalent modality can effectively prevent occupational exposure when surgery performed accordance infection control guidelines. Furthermore, surgical procedure more time-consuming than that on without HIV. The postoperative quality markedly enhanced, there are no reports complications. precise mechanism underlying HIV-infected remains unclear. Potential contributing factors identified, including systemic immune response, inflammatory local microenvironmental changes head, unique anatomical structure others. A profound comprehension disease's pathogenesis facilitate implementation prevention strategies, as well development alternative conservative therapeutic options. represents promising avenue for future research. article reviews epidemiological study osteonecrosis possible mechanisms during treatment, efficacy. aim provide insights inform diagnosis, prevention, this condition.

Language: Английский

Femoral head and acetabular necrosis combined with hip subluxation in people with HIV: a case report and literature review

BMC Musculoskeletal Disorders, Journal Year: 2024, Volume and Issue: 25(1)

Published: Oct. 1, 2024

Language: Английский