Strongyloidiasis co-occurrence with tuberculosis and aspergillosis in immunocompromised patients: a global scoping review DOI Creative Commons

Christian Ide,

David E. Elem,

Thelma E. Bassey

et al.

The Egyptian Journal of Internal Medicine, Journal Year: 2024, Volume and Issue: 36(1)

Published: Aug. 22, 2024

Abstract Reports on cases of strongyloidiasis and tuberculosis or aspergillosis coinfection are fragmented in the literature no large-scale reviews describing its occurrence across globe. We identified a total 230 amongst 2376 participants with disease from eight epidemiological surveys conducted Ethiopia ( n = 4, 50%); Tanzania 3, 37.5%) Malaysia 1, 12.5%). Clinical outcomes these studies were not stated as they largely descriptive. In addition, there ten individual case reports coinfection. Of ten, four USA (40%), two each India (20%) Japan (20%), one UK (10%) Argentina (10%). six had favourable outcomes, fatal unclear remainder. Ten identified, five reported (50%), Netherlands (10%), China Iran Colombia Italy Five outcomes. Fatal associated steroid therapy 3), decline for treatment 1), delayed diagnosis 2) presentation 1). Our findings suggest significant proportion individuals living also affected strongyloidiasis, especially sub-Saharan Africa. However, more required to ascertain burden few other highly burdened regions. role attending clinician is critical reduce morbidities coexistence clinical entities number documented fatal.

Language: Английский

Evaluation of the LDBio ICT IgG/IgM lateral flow assay versus the Bordier Elisa assay for the diagnosis of chronic pulmonary aspergillosis in Nigeria DOI Creative Commons
Oluwaseyi Jessy Balogun, Rita Oladele, O.O.E. Ajibola

et al.

Microbiology Spectrum, Journal Year: 2025, Volume and Issue: unknown

Published: Feb. 6, 2025

The detection of anti-Aspergillus antibodies is key for diagnosing chronic pulmonary aspergillosis (CPA). Available techniques are limited and pose a considerable challenge in resource-limited settings. objective this study was to evaluate the performance point-of-care test LDBio ICT IgG/IgM lateral flow assay (LDBio) versus that Bordier Elisa field Nigeria. Of 97 serum samples tested CPA patient group, 71 positive by with 69.4% sensitivity. In non-CPA 286 289 sera negative 98.7% specificity. tested, showing 100% sensitivity, significantly different from detecting Aspergillus (P < 0.0001). However, there no significant difference specificity between two tests = 0.617). results were agreement 353 386 (91.5%), Cohen's kappa coefficient 0.75, indicating substantial results. (LFA) simple rapid can be used studies which not available. lower sensitivity LFA our could have been due A. fumigatus being species involved only 50%-60% cases Nigeria, flavus more frequent than Northern countries.IMPORTANCEAvailable IgG settings terms affordability, skilled personnel, equipment, regular power supply. A would address most these challenges. When combined clinical features, as screening tool such ours; however, observed compared Elisa.

Language: Английский

Citations

0
Delayed Diagnosis of Chronic Pulmonary Aspergillosis in a Nigerian: A Concern for an Attending Clinician in a Tuberculosis Rife Setting DOI
Bassey E. Ekeng,

Ako H. Itam,

Anthony Offiong

et al.

SN Comprehensive Clinical Medicine, Journal Year: 2025, Volume and Issue: 7(1)

Published: March 1, 2025

Language: Английский

Citations

0
Prevalence of Chronic Pulmonary Aspergillosis in Patients With Mycobacterial and Non‐Mycobacterial Tuberculosis Infection of the Lung: A Systematic Review and Meta‐Analysis DOI
Inderpaul Singh Sehgal, Soundappan Kathirvel, Ritesh Agarwal

et al.

Mycoses, Journal Year: 2025, Volume and Issue: 68(4)

Published: April 1, 2025

ABSTRACT Background Post‐mycobacterial residual lung abnormality (PMLA) from prior tuberculous (PTLA) or non‐tuberculous mycobacterial (PNTLA) infections predisposes to chronic pulmonary aspergillosis (CPA). However, the prevalence of CPA in patients with PMLA remains uncertain. We aimed determine PMLA. Methods performed a systematic search PubMed and Embase databases up January 31, 2025, identify studies reporting PTLA PNTLA (excluding those active tuberculosis). The pooled was calculated using frequentist meta‐analysis (primary outcome), Bayesian trim‐and‐fill methods as sensitivity analyses. Study heterogeneity ( I 2 ) publication bias were assessed. multivariable meta‐regression evaluate factors affecting heterogeneity. Results Thirty‐one (4172 13,905 PNTLA) included. Frequentist yielded 18% (95% confidence interval [CI], 11.6–25.4). analysis informative priors estimated 7.1% Credible Index, 4.5–10.4), adjustment for suggested be 3.4% CI, 0.69–7.7). On analysis, we found higher hospital‐based studies, high TB burden settings prospective cross‐sectional study designs; although (23.1%) than (7%), it not significantly different. detected substantial = 98.8%) bias. Conclusion There is PMLA, particularly TB‐endemic regions hospital settings. Patients should routinely screened

Language: Английский

Citations

0
Strongyloidiasis co-occurrence with tuberculosis and aspergillosis in immunocompromised patients: a global scoping review DOI Creative Commons

Christian Ide,

David E. Elem,

Thelma E. Bassey

et al.

The Egyptian Journal of Internal Medicine, Journal Year: 2024, Volume and Issue: 36(1)

Published: Aug. 22, 2024

Abstract Reports on cases of strongyloidiasis and tuberculosis or aspergillosis coinfection are fragmented in the literature no large-scale reviews describing its occurrence across globe. We identified a total 230 amongst 2376 participants with disease from eight epidemiological surveys conducted Ethiopia ( n = 4, 50%); Tanzania 3, 37.5%) Malaysia 1, 12.5%). Clinical outcomes these studies were not stated as they largely descriptive. In addition, there ten individual case reports coinfection. Of ten, four USA (40%), two each India (20%) Japan (20%), one UK (10%) Argentina (10%). six had favourable outcomes, fatal unclear remainder. Ten identified, five reported (50%), Netherlands (10%), China Iran Colombia Italy Five outcomes. Fatal associated steroid therapy 3), decline for treatment 1), delayed diagnosis 2) presentation 1). Our findings suggest significant proportion individuals living also affected strongyloidiasis, especially sub-Saharan Africa. However, more required to ascertain burden few other highly burdened regions. role attending clinician is critical reduce morbidities coexistence clinical entities number documented fatal.

Language: Английский

Citations

0