Analogs of the anti-malaria drug mefloquine have broad-spectrum antifungal activity and are efficacious in a model of disseminated Candida auris infection DOI
Soumitra Guin, Marhiah C. Montoya, Xiaoyu Wang

et al.

Antimicrobial Agents and Chemotherapy, Journal Year: 2024, Volume and Issue: 68(11)

Published: Oct. 4, 2024

ABSTRACT Only three classes of antifungal drugs are currently in clinical use. Here, we report that derivatives the malarial drug mefloquine have broad-spectrum activity including difficult-to-treat molds and endemic fungi. Pharmacokinetic efficacy studies NSC-4377 indicate it penetrates central nervous system is active against Candida auris vivo . These data strongly support further development analogs as a potentially new class molecules.

Language: Английский

Antifungal Structure–Activity Relationship Studies of Broad-Spectrum Phenothiazines DOI Creative Commons

Samantha C. Brosend,

Soumitra Guin,

Gregory Giovine

et al.

ACS Omega, Journal Year: 2025, Volume and Issue: unknown

Published: April 29, 2025

Language: Английский

Citations

0
Analogues of the anti-malaria drug mefloquine have broad spectrum antifungal activity and are efficacious in a model of disseminated Candida auris infection. DOI Creative Commons
Soumitra Guin, Marhiah C. Montoya, Xiaoyu Wang

et al.

bioRxiv (Cold Spring Harbor Laboratory), Journal Year: 2024, Volume and Issue: unknown

Published: Aug. 30, 2024

Only three classes of antifungal drugs are currently in clinical use. Here, we report that derivatives the malarial drug mefloquine have broad spectrum activity including difficult to treat molds and endemic fungi. Pharmacokinetic efficacy studies NSC-4377 indicate it penetrates central nervous system is active against

Language: Английский

Citations

0
Analogs of the anti-malaria drug mefloquine have broad-spectrum antifungal activity and are efficacious in a model of disseminated Candida auris infection DOI
Soumitra Guin, Marhiah C. Montoya, Xiaoyu Wang

et al.

Antimicrobial Agents and Chemotherapy, Journal Year: 2024, Volume and Issue: 68(11)

Published: Oct. 4, 2024

ABSTRACT Only three classes of antifungal drugs are currently in clinical use. Here, we report that derivatives the malarial drug mefloquine have broad-spectrum activity including difficult-to-treat molds and endemic fungi. Pharmacokinetic efficacy studies NSC-4377 indicate it penetrates central nervous system is active against Candida auris vivo . These data strongly support further development analogs as a potentially new class molecules.

Language: Английский

Citations

0