Preliminary Evaluation of a Mindfulness Intervention Program in Women with Long COVID Dysautonomia Symptoms

Brain Behavior & Immunity - Health, Journal Year: 2025, Volume and Issue: unknown, P. 100963 - 100963

Published: Feb. 1, 2025

The symptom burden for patients with Long COVID-associated dysautonomia is high, yet there are currently no effective treatments. Mindfulness programs reduce psychological and physical symptoms as well inflammatory gene expression in a variety of medical conditions. study aim was to evaluate the effect six-week mindfulness program women COVID symptoms. Using single arm, pre- posttest design, aged 18-54 years orthostatic intolerance suggestive were recruited from center. Participants attended standardized, six-week, virtual program. An active stand test 6-min walk (6MWT) performed at baseline post-intervention. Self-reported measures mental health collected baseline, post-intervention 4 week follow up included composite autonomic score (COMPASS-31), perceived stress (PSS), anxiety (GAD7), depression (PHQ8), COVID-19 event specific distress (IES-R), fatigue (FSI), sleep (ISI), well-being (MHC-SF), resilience (CD-RISC 10), quality life (SF-20). effects on conserved transcriptional response adversity (CTRA) examined by next-generation sequencing dried whole blood samples. Twenty participants enrolled mean age 39.9 (range 21-52 years). No significant changes observed or 6MWT. A reduction insomnia severity (ISI: 16.6 vs. 13.6; p = 0.001) post-intervention, but scores reverted toward levels 4-week follow-up. improvements seen symptoms, anxiety, stress, depression, well-being, related distress. Pro-inflammatory CTRA decreased significantly pre-to (p 0.004). Declines most among those 3 positive events 0.01), followed 2 0.04) 1 0.05). did not vary function recent illness, hospitalization, demographic characteristics, general history. virtual, may improve dysautonomia. While objective improvement observed, our findings suggest favorable intervention antiviral biology decrease expression. Nonetheless, this population very more attention needed provide multi-modal clinical therapies population.

Language: Английский

Sex, Vaccination Status, and Comorbidities Influence Long COVID Persistence

Journal of Infection and Public Health, Journal Year: 2024, Volume and Issue: 17(11), P. 102562 - 102562

Published: Oct. 5, 2024

There is interest in the public health impact of Long COVID, defined as symptoms that persist or begin after SARS-CoV-2 infection. We aimed to identify demographic and clinical risk factors associated with COVID over time an Upper Middle-Income Country (UMIC) potential biomarkers predictive symptom trajectory.

Language: Английский