Global estimates of lives and life-years saved by COVID-19 vaccination during 2020-2024 DOI Creative Commons
John P. A. Ioannidis, Angelo Maria Pezzullo, Antonio Cristiano

et al.

medRxiv (Cold Spring Harbor Laboratory), Journal Year: 2024, Volume and Issue: unknown

Published: Nov. 4, 2024

ABSTRACT Estimating global lives and life-years saved is important to put into perspective the benefits of COVID-19 vaccination. Prior studies have focused mainly on pre-Omicron period or only specific regions, lack crucial life-year calculations, often depend strong modeling assumptions with unaccounted uncertainty. We aimed calculate by vaccination worldwide from onset campaigns until October 2024. considered different strata according age; community-dwelling long-term care residence status; Omicron periods; before after a SARS-CoV-2 infection. In main analysis, 2.533 million deaths were averted. Eighty-two percent among people vaccinated any infection, 57% in period, 90% pertained 60 years above. Sensitivity analyses suggested 1.4 4.0 saved. Some sensitivity showed preponderance benefit during period. estimated 14.8 (sensitivity range, 7.4-23.6 life-years). Most (76%) over old, but residents contributed 2% total. Children adolescents (0.01% 0.1% saved) young adults 20-29 old (0.07% 0.3% had very small contributions total benefit. Based number assumptions, these estimates are substantially more conservative than previous calculations focusing mostly first year vaccination, they still undeniably demonstrate major overall 2020-2024. The vast majority was secured for portion elderly minority population.

Language: Английский

Estimates of SARS-CoV-2 Infections and Population Immunity After the COVID-19 Pandemic in Austria: Analysis of National Wastewater Data DOI Creative Commons
Uwe Riedmann, Alena Chalupka, Lukáš Richter

et al.

The Journal of Infectious Diseases, Journal Year: 2025, Volume and Issue: unknown

Published: Jan. 28, 2025

Postpandemic surveillance data on coronavirus disease 2019 (COVID-19) infections may help inform future public health policies regarding severe acute respiratory syndrome 2 (SARS-CoV-2) testing, vaccinations, or other COVID-19 measures. We estimate the total SARS-CoV-2 in Austria after end of pandemic from wastewater and utilize these estimates to calculate average national levels infection protection death protection. estimated (5 May 2023, per World Health Organization) up 2024 using a previously published model. These were used an agent-based model (ABM) protection, based waning immunity vaccination previous literature. approximately 3.2 million between 6 2023 23 2024, with 17.8 following 12 2020. The ABM that was 82% higher than before pandemic. This represents relative decrease 8% since 2023. It also shows 95% people infected at least once by 2024. National remained relatively low onset Omicron. findings should be considered for decisions testing practices vaccine booster administrations.

Language: Английский

Citations

0
Global estimates of lives and life-years saved by COVID-19 vaccination during 2020-2024 DOI Creative Commons
John P. A. Ioannidis, Angelo Maria Pezzullo, Antonio Cristiano

et al.

medRxiv (Cold Spring Harbor Laboratory), Journal Year: 2024, Volume and Issue: unknown

Published: Nov. 4, 2024

ABSTRACT Estimating global lives and life-years saved is important to put into perspective the benefits of COVID-19 vaccination. Prior studies have focused mainly on pre-Omicron period or only specific regions, lack crucial life-year calculations, often depend strong modeling assumptions with unaccounted uncertainty. We aimed calculate by vaccination worldwide from onset campaigns until October 2024. considered different strata according age; community-dwelling long-term care residence status; Omicron periods; before after a SARS-CoV-2 infection. In main analysis, 2.533 million deaths were averted. Eighty-two percent among people vaccinated any infection, 57% in period, 90% pertained 60 years above. Sensitivity analyses suggested 1.4 4.0 saved. Some sensitivity showed preponderance benefit during period. estimated 14.8 (sensitivity range, 7.4-23.6 life-years). Most (76%) over old, but residents contributed 2% total. Children adolescents (0.01% 0.1% saved) young adults 20-29 old (0.07% 0.3% had very small contributions total benefit. Based number assumptions, these estimates are substantially more conservative than previous calculations focusing mostly first year vaccination, they still undeniably demonstrate major overall 2020-2024. The vast majority was secured for portion elderly minority population.

Language: Английский

Citations

1